No abstract available.
Humans ; Langerhans Cells* ; Prognosis*

Report. about numeric change of LC between vitiliginous skin(VS) and adjacent normal appering skin (ANAS) are hard to find, Epidermal Langerhans Cell (LC) dersities in VS and ANAS were studied in 18 patient with generalized vitiligo. Adenosine triphosphatase(ATPase) stain was used to characterize LC. Epidermal LC densities were calculated by means of an eye piece reticule and expressed per mm. The results were as follows; 1. The was significant body site variation of LC densities in ANAS and the range of densities of LC per mm were from 668+165 to 1,241 _3 and the mean density of LC per mm was 944+258. 3. The LC densities of VS was similar to that of ANAS(p: not significant). In conclusion quantiative change of epidermal LC in vitiligo doesn't seem to have significant relation with pathogenesis of vitiligo.
Adenosine ; Humans ; Langerhans Cells ; Skin ; Vitiligo*

No abstract available.
Animals ; Guinea Pigs* ; Guinea* ; Langerhans Cells*

No abstract available.
Adenosine Triphosphatases* ; Animals ; Langerhans Cells* ; Mice* ; Oxygen*

No abstract available.
Animals ; Langerhans Cells* ; Mice ; Mice, Inbred C3H*

Langerhans cell histiocytosis (LCH) is a rare disorder characterized by the proliferation of dendritic cells resulting in local or systemic symptoms. The clinical symptoms of patients with Langerhans cell histiocytosis depend on the site and the degree of involvement. This article describes two case histories of unifocal bony Langerhans cell histiocytosis with mandibular involvement and further discusses the appropriate management of such via a review of the literature.
Dendritic Cells ; Histiocytosis, Langerhans-Cell ; Humans ; Mandible

Indeterminate dendritic cell tumor (IDCT) is a dendritic cell tumor that displays histologic features similar to those of Langerhans cells. The origin of the indeterminate cells may represent precursors of Langerhans cells or skin dendritic cells. IDCT is extremely rare, and tumor progression and predictive factors are not well known. Here, we report a case of a 61-year-old man who presented with a papule on his back and was finally diagnosed with IDCT based on histology and immunohistochemistry. The tumor recurred three months after surgical excision.
Dendritic Cells ; Humans ; Immunohistochemistry ; Langerhans Cells ; Middle Aged ; Recurrence ; Skin

Langerhans cell histiocytosis is a rare disease in which the Langerhans cells proliferate abnormally, like a cancer, and involve various tissues and organs, such as skin, bone, lung, lymph node, liver and spleen. Especially, in the younger age, it usually involves more organs and tissues, sometimes including the thymus. But isolated involvement of thymus is very rare. We report an 11-month-old-girl with an isolated thymic involvement of Langerhans cell histiocytosis with a brief review of related literatures.
Histiocytosis, Langerhans-Cell* ; Langerhans Cells ; Liver ; Lung ; Lymph Nodes ; Rare Diseases ; Skin ; Spleen ; Thymus Gland

BACKGROUND: Langerhans cell histiocytosis (LCH) is a broad spectrum of clinical diseases having proliferation of Langerhans cells in common. LCH may be manifested in a variety of ways, ranging from a spontaneously regressing skin lesion to a multisystemic life-threatening disorder. Congenital self-healing reticulohistiocytosis is widely regarded as a limited form of LCH. It is present at birth or shortly thereafter and involute spontaneously. OBJECTIVE: Our purpose was to investigate the relationship between clinicopathologic characteristics and prognosis of LCH in children. METHODS: Six children with LCH were investigated clinically and histopathologically. Immunostains were performed with CD1a and S100 antibodies in 5 cases using paraffin-embedded sections and an electron microscopic examination was done in 1 case. RESULTS: Among the 6 cases of LCH, 4 cases were confined to the skin, and 2 cases showed internal organ involvement. All LCH confined to the skin showed resolution of the skin lesion in 1 year, and 2 cases involving internal organ showed bad prognosis. Histopathological findings showed large histiocytes with eosinophilic cytoplasm in common. Immunohistochemical stains (5 cases) showed positive reactions with CD1a and S-100, and electron- microscopical observation in one case demonstrated laminated dense bodies. There was no significant histopathological or immunohistochemical difference between LCH confined to the skin which showed resolution of lesions and LCH involving internal organs with grave prognosis. CONCLUSIONS: Clinical types of Langerhans cell histiocytosis could not be differentiated only from the histopathological findings of the skin. The distinction between Langerhans cell histiocytosis confined to the skin showing spontaneous resolution and congenital self-healing reticulohistiocytosis remains to be clarified.
Antibodies ; Child* ; Coloring Agents ; Cytoplasm ; Eosinophils ; Histiocytes ; Histiocytosis, Langerhans-Cell* ; Humans ; Langerhans Cells ; Parturition ; Prognosis ; Skin

Eosinophilic granuloma of bone is a self-limited condition, characteristically a disease of children and young adults. It is the most benign variant of histiocytosis X. It is most common in skull, but any bone may be affected. Vertebral involvement occurs in about 10 to 15%. This benign bone destructive lesion is characterized by the presence of Langerhans cells contain Birbeck granules, infilitration of histiocytes and eosinophilic leukocytes unknown origin. We report a eosinophilic granuloma in lumbar spine of old patient.
Child ; Eosinophilic Granuloma* ; Eosinophils* ; Histiocytes ; Histiocytosis, Langerhans-Cell ; Humans ; Langerhans Cells ; Leukocytes ; Skull ; Spine* ; Young Adult