Objective:To investigate the intervention effect of the compound polygonum cuspidatum sieb.et Zucc.grain on endothelium dependent dysfunction in patients with coronary artery disease.Methods:Twenty-four patients with both confirmed diagnosis of coronary artery disease(diagnosed by coronary arteriography) and endothelium dependent dilation(EDD) [expressed by flow mediated dilation(FMD) examined through high-resolution ultrasound] were enrolled into this investigation.They were divided into Group CAD,and Group HZ at random.Each group consisted of 12 patients.Group HZ,was administered the compound polygonum cuspidatum sieb.et Zucc.grain 10 grams per time,three times a day for 14 consecutive days.EDD0 and EDD14 were examined before and after the administration of the compound polygonum cuspidatum sieb.et Zucc.grain for 14 days.Group of normal control(Group NC) consisted of 12 age-and sex-matched healthy people.Results:EDD0 and EDD14 were(11.76?0.95)% and(11.83?0.70)% in Group NC,(5.37?1.15)% and(5.50?1.01)% in Group CAD which had significant difference compared with Group NC,(5.62?1.22)% and(9.84?1.83)% in Group HZ which were significantly different from those in Group NC.In GroupHZ,EDD14 was higher than EDD0 and had no significant difference compared with Group NC.Conclusion:The compound polygonum cuspidatum sieb.et Zucc.grain can improve endothelium-dependent dysfunction in patients with coronary artery disease.

Adolescent ; Adult ; Factor Analysis, Statistical ; Female ; Humans ; Male ; Middle Aged ; Needlestick Injuries ; epidemiology ; etiology ; Personnel, Hospital ; statistics & numerical data ; Retrospective Studies ; Risk Factors ; Young Adult

ObjectiveTo observe the effect of the scalp acupunction on children with cerebral palsy.Methods56 cases with cerebral palsy were divided into two groups: the treating group(scalp acupuncture and modern rehabilitation) and the control group(modern rehabilitation only) with 28 cases each. The ADL and the motion function were compared. ResultsThere is a significant defference between the two groups on the ADL, while no significant defference was observed on motor function between the two groups.Conclusions Scalp acupuncture is effective on improvment of ADL of the children with cerebral palsy.

Objective　To provide an effective instrument assessed the ability of children's visual-motor integration in China.Methods　1*!798 children aged 3 to 18 years old were randomly sampled from Xi'an city and were tested with VMI-4R test.The reliability and validity were then analyzed.Results　The norms of aged-equivalent,percentile,and standard scores were established.Split-half reliability,coefficient KR20,test-rerest reliability,and interscorer reliability ranged from 0.90 to 0.96(P＜0.01).There are moderately-highly correlation between VMI-4R with WISC-R,WPPSI-R,CRT,FQS,Drawing-A-Man test respectively.Conclusion　VMI-4R has good reliability and stable construction.It can effectively reflect the level of visual-motor integration.It is worth while to use widely as instrument for intelligence screenging and development assessing.

Objective To explore the reason and the degree of dysphoric mood of family members of children with scoliosis, and then make out some countermeasures to ameliorate these dysphoric mood. Methods Divided 64 family members of children with scoliosis into the observation group and the control group randomly. Using nursing intervention in the observation group and none in the control group. Evaluated the mood of 2 groups by the end of research by using the Zung Self-judged scale and the questionnaire. Results Different causes have induced different degree of dysphoric mood of family members of children with scoliosis. After using the nursing intervention, there were significant difference between the 2 groups in dysphoric mood, P

A retrospective survey wag performed among medical staff in a hospital during 2006-2008 with physical examinations and reviews of medical records.Nonalcoholic fatty liver disease(NAFLD)related factors were compared and analyzed for them.Overall detection rate of NAFLD was 13.9%(230/1655)in 2006 and 18.9%(344/1817)in 2008,with statistically significant difference(χ2=15.549,P＜0. 01 ). Among people surveyed over 30 years old, detection rate of NAFLD was 9.4%, 17. 8% and 21.7% for those aged 30 -39, 40 -49 and 50 years and over, respectively in 2006, while 14. 4%, 28. 2% and 30. 5% , respectively in 2008. Detection rate presented a increasing trend in those of younger age. Relative risk for fatty liver was 1. 859 for those with obesity and overweight. Prevalence of NAFLD in medical staff increases year by year. Medical staff should attend for their own health and take measures to prevent them from its potential risk factors and pay more attention to behavioral intervention for NAFLD.

BACKGROUND:Adult central nervous system lacks the ability to regenerate,so it is of great significance to find a new source of neural stem cells.OBJECTIVE:To investigate the differences between basic fibroblast growth factor(bFGF)and epidermal growth factor(EGF)in inducing bone marrow mesenchymal stem cells(MSCs)to differentiate into neurons in vitro.METHODS:MSCs were isolated from normal human bone marrow using density gradient centrifugation and cell attachment method.MSCs were plated in 96-well culture plates at a density of 0.25×108/L and cultured with 200 μL DMEM/F12 for 0,1,2,3,4,5,6,and 7 days,with 20 μL MTT(5 mg/mL)in 5 wells at each time point.The supernatant was removed and 100 μL dimethyl sulphoxide was added to each well for 4 additional hours of incubation.In addition,some cells were exposed to bFGF and EGF.Growth curve was determined with MTT method.Telomerase activity were examined by TRAP(PCR)-ELISA.Additionally,the functional differences of the two cytokines were checked by RT-PCR.RESULTS AND CONCLUSION:RT-PCR revealed that nestin,glial fibrillary acidic protein(GFAP)and neurofilament subunit M (NF-M)mRNA were expressed in un-induced MSCs of passage 4.Nestin expression reduced at 7 days.The expression of micro-tubule-associated protein-2(MAP2)mRNA was not detected until the induction,and increased thereafter.The expression of MAP2 mRNA was greater in bFGF+EGF and bFGF alone groups compared with EGF alone group,and the expression of GFAP in EGF alone group was greater than other groups.Results showed that MSCs can be cultivated,proliferated and differentiated into neural stem cells in vitro.The differentiated neural stem cells have the activity of proliferation,but not have the ability of infinite proliferation as tumor cells.

Objective To learn the clinical effect and adverse reaction of hydromorphone for continuous epidural analgesia after cesarean section,and to provide effective anesthesia method for clinical.Methods 116 cases of cesarean section were randomly divided into observation group(65 cases) and control group(51 cases),continuous epidural analgesia was used in the two groups after operation.Among them,hydromorphone + ropivacaine was used for the observation group,morphine + ropivacaine was used for the control group.The analgesic effect and sedation degree of the two groups were evaluated.The adverse drug reactions were observed,and satisfaction of the patients after the operation was investigated.Results 6,9,24 hours after operation,the VAS pain scores of the observation group were lower than those of the control group,the differences were statistically significant(t=3.236,4.970,2.547,all P<0.05).3,6,9,24,48 hours after surgery, the differences of Ramsay sedation score between the two groups were not statistically significant(t=0.717,1.502,0.714,1.051,0.589,all P>0.05).The difference of postoperative first exhaust time between the two groups was not statistically significant(t=0.730,P>0.05).The satisfaction degree of the observation group was significantly higher than that of the control group,the difference was statistically significant(t=2.301,P<0.05).The incidence rate of adverse reactions of the observation group was 7.69%,which of the control group was 11.76%,the difference was not statistically significant(x2=0.552,P>0.05).Conclusion For continuous epidural analgesia after cesarean section,hydromorphone can effectively relieve the pain after operation,the safety of the process is high,and it has good clinical application value.

OBJECTIVE:To discuss the necessity and strategies to establish credibility in drug retailing stores.METHO- DS:The general meaning of credibility and its particular meaning in medicine were explained.The significance of establishing credibility in drug stores was analyzed,and the relevant strategies were suggested.RESULTS & CONCLUSION:Now in the vigorous market competition, only through establishing credibility can drug stores survive and develop.

Establishing harmonious physician-patient relationship is importamt to set up the harmonious society.Some hospitals try in recent years a line the single disease grows the price control charges,which suggest its importamt role in seting up harmonious physician-patient relationship,and greatly attract public's concern as the new measure in this aspect.