The effective therapy of limited stage-small cell lung cancer( LS-SCLC) is combined chemotherapy and thoracic radiotherapy(TRT). Early thoracic irradiation is better than later one. Start of any treatment and end of radiotherapy less than 30 days is associated with improved survival in LS-SCLC patients. Concurrent chemoradiotherapy results in longer survival time than sequential and alternating chemoradiotherapy. There are no clear answers on optimal irradiation dose. Hyperfractinated irradiation may have therapeutic benefit compared with conventional irradiation.

Objective:To analyze the epidemic characteristics and gene type of the Extended-Spectrum ?-Lactamases(ESBLs)-producing Gram-negative bacterium in Chong-qing area from 2002 to 2004,and investigate its distribution of gene typing and drug resistance.Methods:There were 4022 Gram-negative bacterium isolated in clinic from 2002 to 2004,and they were identified and done the drug sensitivity by the microscan walkaway-4.0.ESBLs-producing strains were detected by K-B method and amplified by PCR.The DNA of 108 chosen ESBLs-producing strains were genotyped by Tripure Isolation Reagent.Results:1468 ESBLs-producing strains were detected.The rates of Escherichia.coli and Klebsiella.pneumoniae were 52.5% and 65.8% respectively.The general positive rate of ESBLs-producing was 58.0%.And the rates in year 2002,2003 and 2004 were 68.2%,56.9% and 50.8% 2002 to 2004 respectively.The result of PCR showed that 3 types of gene typing,TEM,SHV and CTX were detected in 108 chosen ESBLs-producing strainsThe TEM type was the main type in E.coli(56/59),E.asburiane(12/13)and P.aeruginosa(6/7)while the SHV type was the main type in K.pneumoniae(28/29).TEM type was the main type for year 2002(75%),both TEM(40%)and SHV(57.1%)for 2003,and TEM for 2004(90.9%)with CTX as infrequent type(3.7%).The resistance rates of ESBLs-producing isolates against penicillins,aztreonam and the third generation cephalosporins were about 56.2%-100%,and almost multi-resistant.Conclusion:The incidence of ESBLs-producing isolates was decreasing by year,and ESBLs-Producing isolates mainly carried TEM and SHV types of ?-Lactamases with the TEM one as the major.Their drug resistances were not so good.Those indicated that it is necessany to strengthen the understanding about bacterium resistance and gene type change,administer medicines reasonably to decrease the resistant ones and control the infection in hospital better.

Objective To investigate the clinical application value and feasibility in the dynamic ECG moni-toring in the diagnosis on patients with sleep apnea syndrome complicated with arrhythmia .Methods A total of 80 cases of sleep apnea syndrome confirmed by polysomnography diagnosis were randomly divided into the two groups,40 cases in each group .The patients in the control group were received routine ECG monitoring ,the observa-tion group were underwent dynamic ECG monitoring ,the arrhythmia detection rate in the two groups were compared . Results The ventricular premature beat ,atrial premature beat,ventricular in patients with Beckoning tachycardia , paroxysmal ventricular tachycardia , paroxysmal atrial tachycardia , first degree atrioventricular block , second degree atrioventricular block,premature atrial arrhythmia with sinoatrial block detected in the control group were 6 cases, 7 cases,9 cases,6 cases,5 cases,1 cases,1 cases,5 cases,respectively.However,21 cases,19 cases,25 cases, 16 cases,19 cases,7 cases,8 cases,14 cases were confirmed in the observation group ,the positive detection rate in cardiac arrhythmias in the observation group were significantly higher than that in the control group (χ2 =19.700, 17.000,13.700,21.200,22.600,53.000,50.500,26.100,all P<0.05).Conclusion Dynamic electrocardiogram can improve the positive rate of arrhythmia ,and have important clinical value in the diagnosis and treatment of sleep apnea syndrome complicated with cardiac arrhythmias ,which is worthy of clinical application .

This article discusses the ethical problem about functional appliance in orthodotic treatment. The problem mainly includes:(1)aacuate diagnosis cant be obtained and exhaustive plan for treatment cant be established. (2)It is lacked to devote your cause, so that making appliance is not normative and meticulous.(3)moral responsibility is not strong when doctors are inquired.The author brings forward some suggestions:(1) it is so hard to study professioinal knowledge,and improving level of treatment and culture.(2)moral responsibility must be strong enough when facing with patients.(3)doctors should attach importance to young patients so as to build a good relation of doctors and patients.

Establishment of depressive animal model is the premise for evaluating the effect and mechanism of traditional Chinese medicine on depression. Many traditional Chinese medicines for depressive treatment in a mouse model of experimental studies have demonstrated a sound antidepressant effect, indicating that traditional Chinese medicine treats depression effectively. Therefore, more and more attentions have been paid in recent years. My article made a summary on depressive animal models of experiment study.

This article discussed the classification of Chinese ancient medieal books in several monographs such as Total Records of Four Bibliographic books on Chinese Medicine,Classification of Motherland Medical Books written by Beiiing University of Traditional Chinese Medicine,Comprehensive Collection of Chinese Book on Chinese Medicine,Initial Classification Table of Traditional Chinese Medical Books written by Library of the Chinese Academy of Traditional Chinese Medicine,and The Directory Association of Traditional Chinese Medicial Books,etc.and studied and analyzed the current status of the classification of Chinese ancient medical books.

In recent years,the bone marrow micrometastasis of esophageal cancer has become the research focus.Many studies show that epithelial cell molecules,angiogenesis markers,chemokine receptor-4 (CXCR-4),HER2,activated leukocyte cell adhesion molecule (ALCAM) and stanniocalcin-1 (STC-1) are closely related to the bone marrow micrometastasis of esophageal cancer.These molecular markers play important roles in esophageal cancer diagnosis,prognosis and treatment.

ObjectiveTo explore help-seeking behavior and treatment towards people with mental illness,so as to provide evidence for intervention measures.Methods 1988 mental disorders in outpatient were selected with a self-developed questionnaire randomly,and regression analysis was carried out.ResultsUnstable marriages and the lack of mental health knowledge were risk factors for actively professional help-seeking contact after first onset of a mental disorder.Median delays of seeking help and treatment in depression,schizophrenia,anxiety disorders and somatoform disorders were 113.5 days,34.0 days,86.5 days,309.0 days and 6.0 months,3.0 months,3.0 months,5.5 months orderly.There were notable difference for primary treatment contact between the four mental disorders ( x2 =46.317,P =0.029 ).No-professional recognition ratio was 17.8％.The ratio of correctly diagnosed and rationally cured with drugs ratio was 10.5％.89.5％ of outpatients had not been given rational drugs then they sought to psychiatry.ConclusionThe delay of help-seeking and treatment in mental illnesses are serious,so it should be taken effective measures to promote the popularization of mental health knowledge and train no-professional doctors in order to improve the behavior of seeking help and provide the ratio of recognition and treatment.

Diabetic retinopathy(DR) is characterized by retinal edema,macular edema,eye sight degeneration,etc.and it can cause blindness .Etiopathogenisis and pathogenesis studies of DR was gradually deep and good curative effects were achieved. The author reviewed by consulting DR relevant treatment literature of traditional Chinese medicine in recent years.In order to provide reference for clinical treatment of DR.

Carcinoma of unknown primary (CUP) is a diagnostic and therapeutic challenge in oncology.The early and correct detection of the primary tumors of CUP is very important to its diagnosis, treatment, therapeutic response evaluation and prognosis prediction.This review summarizes the implications and development of the imaging technologies, especially 18F-FDG PET/CT scan, in the diagnosis, treatment and prognosis prediction of CUP patients.