Purpose:To investigate the therapeutic effect a nd toxicity of combination chemotherapy with navelbine (NVB) and epirubicin (E- ADM) in treating metastatic breast cancer. Methods:37 patients with metastatic breast cancer were treated with combination chemotherapy of vinorelbine 25 mg/m2 d 1.8, E-ADM 60 mg/m2 d 1, 21 days for a cycle, a total of 2-4 cycles, made tracks for 6-37 months. Results:Among 27 patients with 37 metastatis, CR was 37.84%(14/ 37), PR 16.22%(6/37), SD 37.83%(14/37), SD≥6 months,21.62%(8/37), PD8.11%(3/37) , ORR(CR+PR) 54.05%, (CR+PR+SD≥6 months) 75.68%, and TTP was 6-9 months. Th e peak value of the efficiency to the lymph metastasis above the clavicle was 90 .9%. The toxicity was leukopenia,losing hair,milieu phlebitis. 74.07% of cases was in Grade Ⅲ and Grade Ⅳ leukopenia , 11.11% of cases was phlebitis. Conclusions:The combination chemotherapy with navelbine(NVB) an d epirubicin (E-ADM) in treating metastatic breast canser is effective and has acceptable tolerance.

Objective: To explore the value of prenatal ultrasound in diagnosis of congenital dacryocystocele. Methods: The ultrasonographic features of 16 fetuses with congenital dacryocystocele were retrospectively reviewed and the outcome of pregnancy were followed up. Results: The median gestational week detected with prenatal ultrasound was 30.29 weeks, the mean diameter was (8.96±1.96)mm. Congenital dacryocystoceles were unilateral in 12 fetuses and bilateral in 4 fetuses, 10 were female and 6 were male. The typical ultrasonic feature was anechoic cystic mass with clear boundary in relation to the medial and inferior aspects of the fetal orbit. The dacryocystocele resolved spontaneously prenatally in 5 fetuses, resolved spontaneously after delivery in 10 fetuses. One fetus died in caesarean section due to complete placenta previa. Conclusions Congenital dacryocystitis has its characteristic ultrasonographic features, and most cases can disappear naturally in prenatal or early newborns.