Objective To investigate the safety and efficacy of Supreme laryngeal mask airway used in lapa-roscopic cholecystectomy under general anesthesia .Methods 30 general anesthesia patients of ASA grade Ⅰ-Ⅱscheduled for selective laparoscopic cholecystectomy were selected .SBP,DBP,HR and SpO2 were recorded before and after the Supreme laryngeal mask intubation , the effect of ventilation and complication were alao recorded .Results There were no significant changes in HR ,SBP,DBP,SpO2 during Supreme laryngeal mask airway intubation and after intubation(all P>0.05).Conclusion Supreme laryngeal mask airway appears practical in laparoscopic eholecystec -tomy under general anesthesia for its fewer complications ,easy performance ,safety and efficacy .