ObjectiveTo study the clinical effects of X-kn ife in the treatment of intracranial meningiomas.MethodsA retrospective analysis of 52 cases of intracranial meningioma treated by X-knife was made. The peripheral dose was (10 ～20) Gy, with a mean of 13 Gy. Follow-up checkups consisted of clinical examina tions and contrast-enhanced CT scans.ResultsAfter the treatm ent, unilateral m ild hemiplegia occurred in 1 case (1 9%) and local epileptic attack occurred in 2 cases (3 8%). Imaging findings revealed asymptomatic transient peritumoral ed e ma in 12 cases (23 1%). Follow-up imaging lasting (3～92) months (mean, 23 mont hs ) in 40 cases (76 9%) found regression of tumor in 18 cases (45 0%) and unchan ge d tumor size in 22 cases (55 0%).ConclusionsX-knife is an e ffective and safe procedure for meningiomas.

ObjectiveTo evaluate the efficacy of the dual channel deep brain s timulation (DBS) for Parkinson's disease (PD). MethodsThirte en patients with PD presenting bilateral symptoms underwent dual channel DBS of bilateral subthal amic nucleus. The targets were identified by a combination of MRI scanning and m icroelectrode recording. Unified Parkinson's Disease Rating Scale (UPDRS) scores were evaluated postoperatively.ResultsAll the 13 patients w ere followed for 3 months～3 years, with a mean of 6 3 months. When the pulse generator was tur ned on, UPDRS motor scores showed 62 3% symptomatic improvement (75 5% improve me nt in those responsive to dopaminergic therapy) during the “off” status and 24 2% during the “on” status. No complications occurred.Conclusions DBS of bilateral subthalamic nucleus may significantly improve the motor functions in PD patients.

ObjectiveTo evaluate the clinical effects of microelectrode guided stereotactic pallidotomy and/or thalamotomy and deep brain stimulation (DBS) in the management of Parkinson's disease.MethodsA total of 510 patients with P arkinson's disease underwent stereotactic operations and 30 patients underwent D BS from April 1999 to March 2003. The 510 cases consisted of 385 cases of poster oventral pallidotomy (PVP), 91 cases of ventral intermedius (Vim) thalamotomy, 1 2 cases of PVP together with Vim thalamotomy on the same side, 8 cases of PVP on both sides at the same time, 10 cases of PVP on both sides at different times, and 4 cases of PVP on one side while Vim thalamotomy on the other at different t imes. Of the 30 cases of DBS (unilateral, 18 cases; bilateral, 12 cases), target s were located in subthalamic nucleus(STN) in 29 cases and ventralis intermedius nucl eus in 1 case.ResultsUnified Parkinson's disease rating scal e (UPDRS) scores were recorded postoperatively. Of the 510 cases, during the “off” and “on” stat es, symptoms improved by 47 3% and 38 7%, respectively. “On-off” phenomena a nd m otor symptoms disappeared. Follow-up information with a mean of 11 6 months in 2 20 cases revealed excellent outcomes in 130 cases (59 1%), improved in 75 (34 1%), a nd no change in 15 (6 8%). Of the 30 cases of DBS, during the “off” and “on ” state s, symptoms improved by 45 2% and 25 7%, respectively. All the 30 patients wer e followed for a mean of 10.3 months. No parameter adjustment was needed after 1 p ostoperative month in 18 cases, while the adjustment after operation was require d in the remaining 12 cases.ConclusionsPallidotomy is much m ore effective th an thalamotoy in Parkinson's patients with tremor. DBS can effectively control t he patient's motor symptoms.

0.05). The NAA/Cr and NAA/Cho in the Group A were significantly higher than those in the Group B (t=4.235, P=0.011; t=2.832, P=0.031), and the Cho/Cr in the Group A was significantly lower than that in the Group B (t=-2.323, P=0.042). Conclusions ~1H magnetic resonance spectroscopy can improve the diagnostic accuracy of glioma.