Objective To investigate the relationship between the C-reactive protein (CRP) and nonalcoholic fatty liver disease (NAFLD) prevalence.Methods In this study,63,486 workers who had participated in the Kailuan health examination from July 2012 to October 2013 and without history of drinking,myocardial infarction,stroke and cancer and without data incomplete were recruited.The observation population was divided into three groups according to the levels of CRP at baseline:group 1 (＜ 1 mg/L),group 2 (1-3 mg/ L) and group 3 (＞3 mg/L).The prevalence of NAFLD among three groups was observed.Multiple logistic regression was used to calculated relationship between the CRP and NAFLD prevalence.Results The prevalence of NAFLD in group 1,group 2 and group 3 were 26.9％,42.1％ and 49.3％,respectively,and the differences were significant (x2=2 192.31,P ＜ 0.01).Logistic model showed that after adjustment for age,gender,waist circumference and other confounders,the association between CRP and NAFLD was strong and the OR value (95％ CI) among the group 1,group 2 and group 3 were 1.00,1.49 (1.42-1.56),1.54 (1.45 -1.64),respectively.Conclusion CRP is independently associated with the nonalcoholic fatty liver disease.

Objective To investigate the predictive value of C-reactive protein (CRP) in emerging nonalcoholic fatty liver disease (NAFLD).Methods A prospective cohort study was performed.A total of 101510 employees of Kailuan Group Company who underwent physical examination from July 2006 to October 2007 were enrolled as study subjects.The employees with a history of drinking,fatty liver disease,myocardial infarction,stroke,and malignant tumors and incomplete data were excluded.Finally 25843 employees were enrolled in the cohort study.According to the baseline CRP level,these employees were divided into CRP ＜ 1 mg/L group,CRP 1-3 mg/L group,and CRP ＞ 3 mg/L group.The detection rate of emerging NAFLD was compared between groups,and the multivariate logistic regression model was used to analyze the risk of NAFLD in each group.Results With the increasing CRP level,age,systolic pressure,diastolic pressure,waist circumference,body mass index,fasting blood glucose,total cholesterol,serum uric acid,and the proportion of male patients tended to increase (P ＜ 0.01).The detection rate of emerging NAFLD was 24.6％ in the CRP ＜ 1 mg/L group,29.6％ in the CRP 1-3 mg/L group,and 30.6％ in the CRP ＞ 3 mg/L group (x2 =92.10,P ＜ 0.01).The results of the logistic regression analysis showed that after the confounding factors such as age,sex,and waist circumference were corrected,the risk of NAFLD in the CRP 1-3 mg/L group and CRP ＞ 3 mg/L group was 1.09 (95％ CI 1.01-1.17) and 1.24 (95％ CI 1.13-1.35) times that in the CRP ＜ 1 mg/L group.Conclusion CRP is the independent risk factor for the development of NAFLD.