Background: Herpes zoster (shingles) is an acute inflammatory skin disease caused by the reactivation of the Varicel la-zoster virus. International studies show that the disease severely reduces patients’ quality of life, and chronic pain negatively affects daily activities. In clinical practice, bloodletting pricking therapy has been effectively used for herpes zoster, with positive effects including reducing disease symptoms, alleviating skin inflammation, and promoting skin regeneration. Due to the limited research on treating herpes zoster with combined bloodletting pricking therapy and acu puncture, this clinical study was conducted. Aim: To evaluate the effectiveness of combining bloodletting pricking therapy with acupuncture in patients diagnosed with herpes zoster. Materials and Methods: The study was conducted using a non-randomized clinical trial design based at the Internation al School of Mongolian Medicine of MNUMS and the Inner Mongolia International Mongolian Medicine Committee (IMIMC). The study included 70 patients diagnosed with herpes zoster (ICD 10-B02.9) who met the inclusion criteria. The treatment group received bloodletting pricking therapy combined with acupuncture. The control group received Acyclovir 800 mg 5 times daily for 7-10 days and Pregabalin 75 mg twice daily for 14 days. Treatment effectiveness was evaluated using the VAS linear scale for pain assessment, the SF-12 (Short Form-12 health survey) questionnaire for qual ity of life, and the Athens Insomnia Scale (AIS) to measure sleep quality and evaluate insomnia. The treatment outcome was assessed according to the Mongolian Traditional Medicine Diagnostic and Treatment Standards. Results: The average age of participants was 47.29±11.11 in the treatment group and 44.43±11.63 in the control group, with 34% male and 66% female participants. According to the VAS linear scale, the treatment group showed a statistically significant greater reduction in pain (P<0.001). The quality-of-life assessment using the SF-12 questionnaire showed that the Physical Component Summary (SF-12-PCS) in the treatment group increased from 32.71±7.38 before treatment to 52.99±2.02 after treatment (t=-17.18, p<0.001), while in the control group, it increased from 36.10±7.41 to 51.56±7.9 (SF-12-3.9) (p<0.001). According to the AIS questionnaire, the sleep quality in the treatment group was significantly better than in the control group (P<0.05). According to the Mongolian Traditional Medicine Diagnostic and Treatment Standards, the combined treatment of pricking therapy and acupuncture resulted in a 100% recovery rate. Conclusion 1. The combination of bloodletting pricking therapy and acupuncture in treating herpes zoster effectively reduces pain. 2. For patients diagnosed with herpes zoster, combining bloodletting pricking therapy with acupuncture effectively improves quality of life in terms of sleep quality as well as physical and mental functioning.