10.3969/j.issn.2095-4344.2013.24.021

BACKGROUND:IPS e.max Presshas an excelent biocompati bility and corrosion resistance, which obtains satisfactory clinical outcomes on dental veneers, inlay and onlay restorations. But little is reported on molar monolithic restoration by IPS e.max Presscrown.
OBJECTIVE:To evaluate the clinical effects of IPS e.max Press crown on molar repair after root canal therapy.
METHODS:Totaly 215 patients with 324 affected molars, including 88 males and 127 females, aged 22-58 years old, were enroled for repairing with IPS e.max Presscrown. Then the color, shape, fracture and edge coloring of the restoration, marginal discrepancy, secondary caries and gingival health status were assessed after a 3-year folow-up.
RESULTS AND CONCLUSION:During the folow-up, 324 dental restorations met the class A standards for color, marginal discrepancy, shape as wel as secondary caries. In addition,3restoration swere fractured, 14 restorations had margin coloring, and 8 restorations appeared to have gingival inflammation. More than 95% restorations were scored grade A. These results indicate that IPS e.max Press crown applied to molar repair after root canal therapy can achieve ideal outcomes.

Oral lichen planus (OLP) is a common chronic inflammatory disease with unclear etiology, in which disorder of the cell-mediated local immune response plays an important role. MicroRNAs (miRNAs) have been found to play an important role in the occurrence and development of inflammatory responses and autoimmune diseases. In recent years, many studies have reported that miRNAs may be related to OLP. According to a literature review, high expression of miRNA-19a and low expression of miRNA-122, miRNA-199, miRNA-138, miRNA-635 and miRNA-578 may be related to the occurrence of OLP by regulating cytokines such as interleukin, interferon and tumor necrosis factor. The low expression of miRNA-125a and the high expression of miRNA-132, miRNA-146a and miRNA-155 may be related to the severity of OLP by influencing the differentiation of CD4+ T cells in the Th1/Th2 subgroup. High expression of miRNA-26a, miRNA-29a and miRNA-31 and low expression of miRNA-27b, miRNA-200a and miRNA-137 may be associated with malignant risk of OLP through functionally related genomes, transcription factors and miRNA coregulatory networks. Some deficiencies remain in current studies. For example, many studies using microarrays to screen differentially expressed miRNAs have not been further grouped according to the type of OLP or cancer risk.