Objective To contrast and observe the bone marrow stem mobilization induced by Yiqi Wenyang Huoxuefang and G-CSF,and the influence to left ventricle reconstruction. Methods Model rat was made by ligate LAD,quantity of circulation stem cells(CSC) at the first,fifth and tenth day was detected. After be treated 8 weeks,the heart index,the expansion index and the thinning ratio were calculated. Results The quantity of CSC of Chinese herbs group increased at the fifth day(P

Objective The aim of this study was to investigate the differences of the cell ultrastucture of normal mouse hatched blastocysts and their dormant ones cultured in vitro after freezing-thawing, and to explore whether the dor-mant embryos have a better anti-freezing shock property than the normal hatched mouse embryos .Methods By transmis-sion electron microscopy , the ultrastructure of these two types of mouse embryos was observed and analyzed .Results By comparative analysis of their ultrastructure , the results showed that the dormant embryos before freezing are being austerity and with lower energy metabolism at a ‘ground state ’ .After freezing-thawing and culture , their cellular structure seemed to be similar to that of the normal embryos cultured in vitro before freezing.However, after freezing-thawing and culture, the number of mitochondria decreased , the nuclei were loose , and their heterochromatin also increased .Conclusions From the ultrastructural observation , compared with the normal mouse hatched embryos , the cellular state of dormant mouse em-bryos after freezing-thawing is more favorable for material storage and energy metabolism , thus, indicating that they have a better anti-freezing property than normal hatched embryos .

Objective: To investigate the trend in burden of mental disorders among the elderly in China from 1990 to 2021, so as to provide the basis for formulating prevention, control and intervention measures for mental disorders in this population. Methods: Based on the data of the Global Burden of Disease 2021 (GBD 2021), the number of cases, prevalence, disability-adjusted life years (DALY) and DALY rate of mental disorders among the elderly in China were collected, and standardized prevalence and DALY rate were calculated using the world standard population. The burden of mental disorders was analyzed, and the trend in burden was analyzed using average annual percent change (AAPC). Results: The standardized prevalence and standardized DALY rate of mental disorders among the elderly in China showed upward trends from 1990 to 2021 (AAPC=0.160% and 0.286%, both P<0.05). In 2021, there were 38.944 9 million cases of mental disorders among the elderly in China, the DALY was 5.389 8 million person-years, the standardized prevalence was 14 462.91/105, and the standardized DALY rate was 1 993.69/105, with the increases of 184.12%, 192.90%, 5.71% and 9.60% compared to 1990, respectively. The burden of mental disorders increased significantly among the elderly aged 60 to <65, 65 to <70, 70 to <75, and 75 to <80 years, with the increases of 5.81%, 5.92%, 6.08% and 6.03% in prevalence, and the increases of 10.16%, 10.12%, 10.31% and 9.88% in DALY rates, respectively. Depression and anxiety ranked the top two in standardized prevalence and standardized DALY rates. The standardized prevalence and standardized DALY rate of autism showed the largest increases, at 18.82% and 18.10%, respectively, while congenital intellectual disabilities exhibited the largest decreases, at 36.15% and 29.71%, respectively. The standardized prevalence and standardized DALY rate of mental disorders were higher in women than in men (both P<0.05). Compared to men, women had higher standardized prevalence and standardized DALY rates of depression, anxiety and congenital intellectual disabilities, but lower standardized prevalence and standardized DALY rates of schizophrenia, autism, attention deficit hyperactivity disorder, and other mental disorders (all P<0.05). Conclusion The burden of mental disorders among the elderly population in China showed an upward trend from 1990 to 2021, with heavier burdens observed among women, individuals aged 60 to <80 years, and those with depression and anxiety.

OBJECTIVETo compare the dissolution properties of Ginseng micropowder and common powder in vitro and investigate the effect of micronization on dissolution of Ginseng.

METHODSFive ginsenosides including Rg1, Re, Rf, Rb1, and Rb2 were determined by high performance liquid chromatography, and the dissolution curves of Ginseng micropowder and common powder were drawn.

RESULTSThe dissolution rates of ginsenosides from micropowder exceeded 90% within 5 min, significantly greater than that from common powder. But when the powders were packed in tea bags, the dissolution rates of ginsenosides were higher from common powder than from micropowder.

CONCLUSIONMicronization treatments can promote dissolution of ginsenosides from Ginseng.

Chromatography, High Pressure Liquid ; Ginsenosides ; analysis ; chemistry ; Panax ; chemistry ; Particle Size ; Plant Roots ; chemistry ; Plants, Medicinal ; chemistry ; Powders ; chemistry ; Solubility

Objective To compare the dissolution properties of Ginseng micropowder and common powder in vitro and investigate the effect of micronization on dissolution of Ginseng. Methods Five ginsenosides including Rg1, Re, Rf, Rb1, and Rb2 were determined by high performance liquid chromatography, and the dissolution curves of Ginseng micropowder and common powder were drawn. Results The dissolution rates of ginsenosides from micropowder exceeded 90%within 5 min, significantly greater than that from common powder. But when the powders were packed in tea bags, the dissolution rates of ginsenosides were higher from common powder than from micropowder. Conclusion Micronization treatments can promote dissolution of ginsenosides from Ginseng.