The increase of blood-brain barrier (BBB) permeability is a key link in causing the pathological changes in vasogenic brain edema and inflammatory reaction. In recent years, a number of studies have indicaded that a lot of mediators participated in the structural and functional changes and damage of BBB during the process of cerebral ischemia-reperfusion.

There exists different view in the goal of investigative study.Based on the self-fulfilling cycles of self-regulated learning,the author of the article puts forward that developing the ability of self-regulated learning by doing investigative study according to each phase characteristic of self-regulated learning is one of the important goals of investigative study.

C.Conclusion: The drug releasing rate of Icariin Ointment made of emulsion ointment base is the fastest.

Objective To report successful nursing experience of cardiac arrest caused by amniotic fluid embolism.Methods 3 pregnant women with cardiac arrest caused by amniotic fluid embolism from January to August 2012 were successfully rescued,the nursing measures included observation of labor course,mechanical ventilation,rapid establishment of intravenous injection route,anti-shock and prevention of DIC and renal failure.Results 3 cases of pregnant women were given timely rescue and pulled through.All rehabilitated and were discharged.Conclusions Amniotic fluid embolism is the most serious,dramatic,and the most difficult to control complications in obstetric department.Prevention is the key for amniotic fluid embolism,once happened,medical workers should carry out rescue work calmly and implement effective interventions.

Objective To observe the correctly positioning rate of left-sided double lumen endobronchial tube by combined adjustment of auscultation,PETCO2 and airway pressure changes.Methods Sixty adult patients undergoing thoracic surgery were intubated with Robertshaw DLTs. DLT position is checked and adjusted by fiberoptic bronchoscope（FOB）. Results In the supine position,successful intubation is 57 cases by three combined methods,one of cases is shallower,two of cases are deeper,satisfactory rate is 95 percents;In the lateral decubitus position,successful intobution is 56 cases by three combined methods,two of cases is shallower,two of cases are deeper,satisfactory rate is 93.4 percents.Conclusion Three combined methods that are simple,reliable can be used repeatedly during postural changes without increasing the opportunities for injury,it is clinically a very good approach,but the absolute scope of safety is very small,FOB is necessary for positioning.

to observe the clinical effects of warm needling on rheumatoid arthritis.Methods:Patients with rheumatoid were treated with warming needling on the major acupoints of Guanyuan(CV 4),Qihai(CV 6),Zusanli(ST 36),Ganshu(BL 18),Shenshu(BL 23) and Pishu(BL 20),in combination with local acupoints and acupoints on the related meridians,meanwhile,other patients were treated with single needling as control. The patients' joint pain,tenderness,swelling,dysfunction index,gripping force,morning stiffness,walking time of 20 meters,rheumatoid factor,erythrocyte sedimentation rate,C response protein,IgG,IgA,and IgM were measured before and after treatments.Results:Warm needling could improve the rheumatoid arthritis patients' symptoms,and had an effective rate of 86.2%,while the single needling had an effective rate of 57.1%(P＜0.01). And the therapeutic effects were related to the disease duration and condition. Conclusion:Warm needling has a better clinical effects on rheumatoid arthritis than the single needling,with obvious functions of anti-inflammation,relieving pain and regulating immunity.

To study the initiatives and progress of African nations in promoting the development of traditional medicine to determine if these measures can be applied to the protection of traditional Chinese medicine knowledge. Information research methods were used to collect and analyze relevant literature. The development of African traditional medicine has been effectively promoted through various measures taken by African organizations and governments. In recent years, Africa has achieved remarkable results in promoting the development of traditional medicine. Many other countries will benefit from studying their examples and adopting similar measures.

Objective To observe the clinical effect of long-term domiciliary oxygen therapy (LTDOT) on chronic obstructive pulmonary disease(COPD).Methods COPD patients were randomly divided into LTDOT group and control group,LTDOT group received LTDOT on basis of conventional therapy,and control group only received conventional thempy.The lung function,blood gas analysis was detectedand quality of life in paracmasis before and after treatment was evaluted.Results After two years, FEV1[(1.42±0.42)L],PaO2[(80.0±2.6)mm Hg,1 mm Hg=0.133 kPa]in LTDOT group were obviously higher than those in control group[(0.72±0.38)L,(55.0±2.2)mm Hg],there were significant differences between two groups(P<0.01).FVC,PaCO2 in two groups were no significant difference(P>0.05).Quality of life in LTDOT group was better than that in control group,average emergency frequency[(2.3±1.2)times] and hospital day[(16.0±2.4)d]in LTDOT group were obviously decwatsed than those in control group [(5.2±1.3)times,(36.0±2.2)d](P<0.01).Conclusion For the patients with COPD paracmasis, LTDOT can increase FEVI,PaO2,elevate quality of life and decrease average emergency frequency and hospital day.

Objective To study the effect of methyl mercury on the development of rat offspring. Methods The male Wistar rats were divided into four groups randomly, each group was administrated methyl mercury by gavage every two days for two months, then, the rats were mated with healthy female rats. The development, growth and behaviors of offspring were investigated. Results Compared with the control, the body weights of offspring in groups of 1.170 mg/kg and 0.580 mg/kg were less and the development was tardy. The indexes that can reflect the level of development showed that the behaviors of offspring in experimental groups were damaged. Conclusion The male rats exposed to methyl mercury may produce an adverse effect on the development, growth and behaviors of their offspring.

Objective:To investigate the expressions of CD44v3 and CD54 in oral premalignant epithelia and its significance in the carcinogenesis of oral mucosa.Methods:The expressions of CD44v3 and CD54 in 19 cases of normal mucosa and mucosal hyperplasia,22 case of dysplastic epithelia,26 cases of oral cancer mucosa were detected by using immunohistochemistry.Results:CD44v3 and CD54 proteins showed no expression or micro-expression in normal and hyperplastic epithelia.The expressions increased in the dysplastic epithelia and mucosa of oral cancer gradually.The difference between the expressions of the three groups was significant(P