Obesity and vitamin D deficiency have become two public health problems in children.In the past few decades,there has been increasing concern that low circulating levels of serum 25 (OH) D are associated with obesity and other metabolic diseases linked.However,the causal relationship between vitamin D deficiency and obesity is still unclear.There is currently insufficient evidence of beneficial effect to recommend vitamin D supplementation as a means of improving body weight,BMI or fat mass.Obesity probably leads to lower 25 (OH) D starus,while vitamin D and VDR are considered to have the ability to regulate energy balance through acting on adipogenesis,adipocyte apoptosis,lipogenesis and lipolysis,feeding behavior,and energy expenditure.

Henoch-Schnlein purpura(HSP) is a common autoimmune small vessel vasculitis that primarily affects children.Although the pathogenesis of HSP is unknown,there are tantalizing clues on the immune abnormalities mediated by IgA,which mainly affects the vessels of the skin,gastrointestinal tract and kidneys.The reasons of deposition maybe involve in the increases of serum IgA,the abnormalities of IgA-specific autoantibodies,structures and acceptors of IgA1,complements,and so on,which mediates the abnormal expressions of adhesion molecules and cytokines.

Objective To investigate the impact of plasma homocysteine ( Hcy) on type 2 diabetics ( T2DM) patients with diabetic nephropathy ( DN) and diabetic retinopathy ( DR) , and to explore the correlation among the levels of plasma Hcy , vascular endothelial growth factor (VEGF), homeostasis model assessment of insulin resistance (HOMA-IR), and insulin resistance (ISI). Methods A total of 241 cases of diabetes was recruited as subjects according to the 2010 China guideline for type 2 diabetes.The history of smoking, hypertension, duration of diabetes, height, and weight were measured.Fasting blood were collected to analyze the levels of fasting insulin (FINS), fasting plasma glucose (FPG), glycated hemoglobin a1c (HbA1c), plasma Hcy (Rate method), and VEGF [enzyme-linked immunosorbent assay, ELISA)].Results The age, body mass index (BMI), the history of hyperten-sion, duration of diabetes, HbA1c, homeostasis model assessment of insulin resistance (HOMA-IR), microalbuminuria (MAU), and VEGF were positively correlated with the levels of plasma Hcy or VEGF .The levels of ISI were reduced with the increased levels of Hcy or VEGF.The history of smoking was positively correlated with the VEGF .Spearman correlation analysis demonstrated that the levels of plasma Hcy were positively correlated with the levels of VEGF ( r =0.498 , P <0.01 ) .In the groups of diabetic retinopathy and early diabetic nephropathy , it could find that increased duration of diabetes , increased IR, higher levels of HbA1c and VEGF, and the levels of plasma Hcy≥10μmol/L might be the risk factors of DR ( P <0.05 ) .Only the history of hypertension and high levels of VEGF and Hcy in early DN showed a strong correlation ( P <0.05 ) .Conclusions Spearman correlation analysis demonstrated that the levels of plasma Hcy were positively correlated with the levels of VEGF .Higher levels of Hcy and VEGF might be the risk factors of the early DN and DR.At the same time, lower level of ISI might be the risk factor of DR , but the reduction of ISI might not be the main risk factor of the early DN .

Through two years of experimental trials,a species of fresh snail rich in protein containing 0. 45mg/kg selenium was obtained

Objective To investigate the relationship between metabolic syndrome and colorectal cancer. And to further prevent the risks of colorectal cancer and provide methods and evidences.Methods A literature search was performed through CNKI,Wanfang,PubMed,Ovidsp,Cochrane data within the time limit of November 2005 to November 2015.According to the inclusion and exclusion criteria,the studies were screened and the data were extracted.Then,meta -analysis was performed using Review Manager 5.3.5.Results A total of 14 studies(6 case-control studies and 8 cohort studies)met the inclusion criteria.Meta analysis showed that with metabolic syndrome had a higher risk of colorectal cancer incidence compared with the control group without metabolic syndrome(OR =1.18,95%CI:1.33cv1.22,P <0.05).Stratified analysis showed that metabolic syndrome increased the risk of color-ectal cancer between men and women population.The combined effect of the OR respectively (OR =1.12,95%Cl:1.09 -1.14,P <0.05;OR =1.13,95%Cl:1.05 -1.22,P <0.05),the differences were statistically significant. Meta analysis showed that metabolic syndrome was not associated with an increased risk of colon cancer mortality (OR =1.05,95%CI:0.92 -1.19,P =0.46).Conclusion This meta analysis indicate a positive association between meta-bolic syndrome and colorectol cancer incidence,and the association has no gender differences.The metabolic syndrome does not increase the risk of colon cancer death.More prospective cohort study needed to further confirm it.

Wave intensity (WI) is a hemodynamic index, the method of WI measurement is a real-time system in the basis of the eTRACKING technology, which provides the appearance of haemodynamics ahout heart and blood vascular system and their linear correlation with inner diameter-pressure. The research advantages and the application of WI were reviewed in this article.

Objective To discuss the content changes of motilin (MTL) and gastrin (GAS) in acute liver failure (ALF) rats and their association with hepatic gastrointestinal dysfunction.Methods We duplicated the ALF rats model with thioacetamide,and observed their general states of health and the liver biochemical indicators.The contents of MTL and GAS in their blood and the gastrointestinal mucosa were determined with the radio immunoassay.Results ① The contents of MTL and GAS in blood and gastric mucosa of the ALF rats obviously elevated (P

Objective To investigate the regularity of changes an d the base line of physiological deficiency of ventricular diastolic function in normal individuals. Methods Non-invasive echocardiography was employed for monitoring hemodynamics of the ventricular diastolic function in n ormal individuals. 240 volunteers were divided into four groups by age, i.e. juv enile, youth, middle-aged and elderly groups. Items of examination included the diameter of cardiac chambers by two-dimensional (2D) echogram, velocity of dia stole of ventricular wall by M mode, velocity and ratio of blood flow at left an d right atrio-ventricular valves and pulmonary vein by spectral Doppler, fillin g phase and duration of filling of ventricles in diastolic phase by color Dopple r. Results Of mitral valve, tricuspid valve and pulmonary vein, a series of dynamic parameters of blood flow were correlated closely with the a ge. The ventricular diastolic function of normal person deteriorated physiologic ally with the passage of years, characterized by a normal stage in juvenile and young ages, compliant decreased stage in middle-age, and declined functional st age in aged. The declination course started in the left ventricle prior to the r ightventaide. Conclusion The results of the present study may b e helpful for further clinical researches on the mechanisms of changes in human ventricular diastolic function.

AIM: To study the influence of arachidonic acid(AA) on the action potential and L-type calcium current in rabbit cardiomyocytes.METHODS: Single ventricular myocyte was isolated using enzyme dispersion method.Whole-cell clamp-patch technique was used to record action potential and L-type calcium current.RESULTS: ① AA shortened action potential duration obviously,without marked effect on the resting potential and action potential amplitude.② AA reduced the current densities from(10.21?3.15)PA/PF to(6.53?2.17)PA/PF(n=6,P

Objective To investigate the value of dual source CT iodine concentration in the assessment of pathological grade of esophageal carcinoma. Methods Retrospective review was performed on 60 cases with pathologically?confirmed esophageal carcinoma. Among them, 17 tumors were well differentiated, 24 were moderately differentiated and 19 were poorly differentiated. The dual?energy plain scan and double phase enhanced scan of dual?source CT were performed on all 60 cases. Normalized iodine concentration (NIC) and the enhancement degree of the esophageal carcinoma in the arterial and venous phase were measured. The difference of NIC and enhancement degree among different grades of esophageal carcinoma were analyzed by analysis of variance. To evaluate the efficiency of NIC and enhancement degree in differentiating the well?moderately differentiated esophageal carcinoma from poorly differentiated esophageal carcinoma, ROC curve was plotted. Results The NIC values of the well differentiated, the moderately differentiated and the poorly differentiated esophageal carcinoma in the arterial phase were (1.54±0.34),(1.72±0.50)and(2.10±0.40)mg/ml, respectively;the NIC values in venous phase were(1.55± 0.52),(1.80±0.62)and(2.18±0.35)mg/ml,respectively, and the degrees of CT enhancement in venous phase were(25.65 ± 4.43),(27.55 ± 6.82)and(30.77 ± 6.38)HU, respectively. The differences between groups were statistically significant(P<0.05). The degrees of CT enhancement of well differentiated, moderately differentiated and poorly differentiated esophageal carcinoma in arterial phase were(14.40 ± 3.91),(14.26 ± 7.35)and(16.17 ± 6.89)HU, respectively, and there were no statistically significant differences(P=0.582). Areas under the ROC curves to differentiate well?moderately differentiated from poorly differentiated esophageal carcinoma for NIC in arterial phase, NIC in venous phase and the degree of CT enhancement in venous phase were 0.801, 0.817 and 0.730. Conclusion The iodine concentration measured on dual source CT has a certain value in evaluating the pathological grades of esophageal carcinoma.