Objective To study the application of contact oxidization and hydrolysis acidifying technology in hospital wastewater treatment. Methods Hydrolysis combined with chlorine dioxide disinfection was used in the engineering of treatment. Results Even if CODCr was 300 mg/L, BOD5 was 150 mg/L, SS was 300 mg/L, pH was 6-9 and large intestine bacteria number was 50 000/L, the wastewater quality met the requirement of related standard after treated with the present method. Conclusion The present technology was efficient, practical and economical.

OBJECTIVE: To develop a unified and discriminative method for the characterization of different diclofenac sodium extended release tablets. METHODS The flow-through cell method was employed to investigate the dissolution characteristics of all the samples at different flow rates and in different dissolution media. The dissolution data under the finally selected dissolution condition was also used to analyze the similarity of dissolution curves and statistical significance of Weibull parameters. RESULTS: The dissolution behaviors of the samples were not significantly influenced by flow rates in the selected range. The dissolution at a flow rate of 4 mL · min-1 and in hydrochloric acid (0.1 mol · L-1) for one hour followed by water for another seven hours was satisfactory to discriminate the samples, which was demonstrated by f2 and Weibull parameters analysis. CONCLUSION: This method can be used for dissolution tests of diclofenac sodium extended release tablet samples from the manufacturers in this study with meanings in guiding both comprehensive investigation on the dissolution of diclofenac sodium extended release tablets and quality improvement of generic drugs.

Rehabilitation medicine is a comprehensive multi-discipline. It is important to use varied Methods , modern and traditional, rationally in teaching rehabilitation medicine to improve the quality and efficiency. Some of these Methods were discussed.

BACKGROUND:Three-dimensional (3D) nanofiber scaffolds are aimed to mimic the physical and chemical signals of stem celsin vivo. 3D nanofiber scaffolds, which are capable to maintain the activity of stem cels, are promising in tissue regeneration and stem celltherapy. OBJECTIVE:To review the synthesis methods for 3D nanofiber scaffolds, and the interactions of stem cels and 3D scaffolds as wel as the current progress of 3D nanofiber scaffolds in tissue engineering. METHODS:Web of Science was searched with key words of “tissue engineering, nanofiber scaffold, stem cellfate” in English for articles relevant to stem celltissue engineering and 3D nanofiber scaffolds. RESULTS AND CONCLUSION:3D nanofiber scaffolds can mimic the physical architecture ofin vivo microenvironment due to its nano-scale topology. Chemical modification of scaffolds endows chemical cues to stem cels. Therefore, 3D nanofiber scaffold can be a promising delivery vehicle of stem cels in tissue engineering. Nanofiber scaffolds can be synthesized through self-assembly, sol-gel phase separation, and electric spinning. 3D nanofiber scaffolds have been shown to improve thein vitro proliferation of hematopoietic stem cels, embryonic stem cels, mesenchymal stem cels, and neural stem cels. 3D nanofiber scaffolds with specific topology/chemical properties can induce the differentiation of stem cels into bone, cartilage, nerve, or muscle. 3D nanofiber scaffold which provides a satisfactory microenvironment for stem cellenhance the performance of stem celltherapy.

BACKGROUND:Self-assembling peptide scaffolds have attracted much more attention among three dimensional biomaterials due to its biocompatibility, biodegradation, and tailor-made properties.
OBJECTIVE:To review the structure and design of functionalized self-assembling RADA peptide, and the recent advances in the use of RADA self-assembling peptide for three-dimensional cel culture in cel therapy applications.
METHODS:Total 224 literatures related to self-assembling peptide and tissue engineering from PubMed, Web of Science and CNKI databases were screened out for this review. The keywords were“self-assembly peptide, tissue engineering”in English and Chinese, respectively. Final y 48 of 224 articles about the design, fictionalization, and three-dimensional cel culture of peptide scaffolds were included in this review.
RESULTS AND CONCLUSION:Self-assembling peptide could undergo spontaneous assembly into wel-ordered interwoven nanofibers in water and rapidly form hydrogel, which physical y mimics the architecture of natural extracel ular matrix to ensure a real three-dimensional microenvironment for cel s. In terms of bio-function, this material can be tailor-made with various bioactive short peptide motifs to promote cel adhesion, proliferation, and differentiation.

gress. A growing body of research has committed to exploring more thrombolytic regimens. This article reviews the main methods, drugs and recent progress in thrombolytic therapy.

Vitamin K deficiency is a common problem in neonates and infants,vitamin K deficiency bleeding can be life threatening.There is still a high incidence of vitamin K deficiency even if the prevention by retrospective analysis a large number of the global data.In recent years,with the increase of premature infants,incidence is higher than before,China is the same trend.There is no recognized prevention and treatment measures,and less related research data.Therefore,to carry out related investigation,to provide the basis for clinical prevention and treatment are an urgent task.

Endovascular coil embolization is the first primary technique of choice for treating intracranial aneurysms in many centers around the world ,but some patients still got recanalizations months later,that may lead to death or severe disability just as the same in neurosurgery. This review showed the technic details of the first generation of Matrix bioabsorbable poly-meric material coil ,and analyzed clinical results among many treatment centers,involving the therapeutic measure of intracranial aneurysms.

0.05). However, there were quite improvements of survival rate and survival quality for cervical adenocacinoma. Their 5-year survival rates were 91% and 33% (P