BACKGROUND: Basic fibroblast growth factor (BFGF) widely in human tissue participates in trauma repair of various tissues and is one of wound healing factors in the body. OBJECTIVE: To summarize the progress of BFGF in the fracture healing. RETRIEVAL STRATEGY: A computer-based online search of Pubmed Database was undertaken to identify the relevant articles on BFGF in the fracture healing published from January 2000 to December 2007 with the Keywords of "fibroblast growth factor 2 (basic fibroblast growth factor), fracture healing, regulation, signal transduction" in English. At the same time, Chinese relevant articles were searched in China Journal Full-text Database (CJFD) and Wanfang Database published between January 2000 and December 2007 with the same key words in Chinese. Exclusive criteria included articles with repetitive research and non-original study. LITERATURE EVALUATION: A total of 33 articles were collected about the distribution (3 articles), biological characteristics (3 articles) and the effect on the healing of bone fracture (27 articles) of BFGF. DATA SYNTHESIS: Bone healing is the process of regeneration after bone injury and the process of bone formation. BFGF can promote the cell migration by its chemotaxis and accelerate the healing by aggregating mesenchymal stem cells, macrophage and fibroblasts towards trauma region. Present animal studies on BFGF are deep and reports on clinical application are a few. Thus, the effect of BFGF is available. BGFG can affect bone formation by adjusting cell prolifeation and differentiation and changing the synthesis of cell products. BGFG not only can promote the bone growth, but also enhance the adhesion of osteoblasts and scaffold. CONCLUSION: The distribution and biological characteristics of BGFG have been recognized primarily. The further study on modulatory mechanism in the fracture healing of BFGF is carrying through. The bone restoration compounded by BFGF and its carriers is in the experiment and needs to be studied further.

OBJECTIVE To evaluate the effect of air disinfection methods to improve air quality in dental clinic.METHODS Electrostatic attraction method was used to disinfect air in dental clinic.Air samples here collected before,during and after daily and treatments compared.Bacterial colonies were counted. The air effect of disinfection was compared with undisinfected control group in terms of total number of germs.RESULTS Bacterial count of disinfected group was lower than that of undisinfected group(P

Objects:To investigate the current situation of interpersonal communication inpreparatory students in one Xinjiang medical college from the exchanges between students.Methods:Using self-developed questionnaire,a survey was conducted among 200 preparatory students and depth interviews were conducted for typical cases.Results:Preppies showed a strong willing of interpersonal communication.In the process of students' interaction,some features were presented as followings:pure motives but dissimilarity,narrow range of interactions,lack of interaction ability and the single form of social activities.Conclusion:Based on the above current situation of interpersonal communication in preparatory students,it should enhance the language application ability of preparatory stage,change the idea and attach importance to the education of humanistic quality in preparatory education and train preppy's expression and listening art.

Drug position is the unique clinical value in clinical doctors or patients and medical literature evidence is the important evidence for the effective delivery of drug position information to the users.The logistic relation of the basis for medical literature evidence linage construction with the search of clinical research evidence, selection and assessment of medical literature evidence and creation of medical literature evidence was thus systematically expounded in this paper in order to provide certain enlightenments for the relevant researchers.

Objective To investigate the clinical values of loop electrosurgical excision procedure (LEEP) in diagnosis and treatment of cervical intraepithelial neoplasia(CIN). Methods Fifty-two patients with cervical intraepithelial neoplasia underwent LEEP following cytology, colposcopy and multiple biopsies, were treated by LEEP. The cure rate, the operative time, bleeding volume and patients reaction of LEEP to the cervical intraepithelial neoplasia were investigated during the follow-up. Results The effective rate was 98.07 % in the patients treated by LEEP. The effective rate was 100 % in the patients in grade CIN Ⅰ or CIN Ⅱ by LEEP. No patients in grade CIN Ⅰ and Ⅱ had recurrence during the follow-up 1 year. The mean operative time was 7.8 minutes. The mean bleeding volume was 10 ml. No secondary bleeding and post-operative infection occurred. All these surgical specimens were checked successfully for pathology diagnosis. Conclusion The advantages to use the LEEP to manage cervical intraepithelial neoplasia include its simpleness to handle, short operative time,less bleeding, less vaginal discharge, safety, and high cure rate. LEEP can offer intact sample for pathological diagnosis. LEEP electrotome is a very ideal therapy for the cervical intraepithelial neoplasia, and can block the development of precancerosis to infiltrating carcinoma effectively.

Objective To study the mechanism of toxicity of hexane. Methods SD rats inhaled 15 g/ma n-hexane statically for 8 hours. Results The levels of GSH in whole blood of rats declined significantly (t-test,P＜0. 01). The levels of MDA in serum of rats revealed increasing trend but without statistical significance (t-test,P＞0. 05). The activities of SOD and GSH-Px in liver of rats decreased significantly (t-test,P＜0.01). Conclusion n-Hexane could induce or enhance the reaction of oxygen free radical in organism,and result in damages of lipid peroxidation,which might be one of the mechanisms of the toxicity of alkane.

Epigenetic regulation involved in eukaryotic gene expression plays an important role in the progression of colorectal cancer. Colorectal cancer epigenetics is evolved in DNA methylation which is associated with the activation of oncogene and inactivation of tumor suppressor gene. The potential reversibility of DNA methylation offers exciting opportunities for therapy and diagnosis of colorectal carcinoma.

ObjectiveTo explore the effect of aerobic exercise on serum leptin,interleukin-18 (IL-18),soluble intercellular adhesion molecule-1 (sICAM-1),C reaction protein (CRP) concentration,and homeostasis model assessment insulin resistance (HOMA-IR) of patients with metabolic syndrome ( MS),and to explore its mechanism.MethodsForty sedentary patients with MS were randomly divided into exercise group and fenofibrate group.Patients in exercise group were trained at anaerobic threshold intensity (30 min/times) for 12 weeks (5 times/wk).Patients in fenofibrate group were treated with fenofibrate 200 mg every night.Serum leptin,IL-18,CRP,and sICAM-1 concentration were measured by enzyme linked immunosorbent assay (ELISA).Twenty healthy subjects were selected as the control group.ResultsSerum concentration of leptin [ ( 26.04 ± 9.07 ) ng/ml vs ( 8.32 ± 2.94 ) ng/ml,t =12.72,P ＜0.01 ],IL-18[ (308.27 ±50.39)pg/ml vs (230.60 ±29.15)pg/ml,t =6.41,P ＜0.01 ],CRP[ (2.65±0.57)ng/ml vs ( 1.26 ±0.23) ng/ml,t =9.69,P ＜0.01 ],sICAM-1 [ (331.89 ±60.08) ng/ml vs (246.43±39.32)ng/ml,t =5.98,P ＜0.01],and HOMA-IR(4.38 ±2.06 vs 2.12 ± 0.50,t =4.81,P ＜ 0.01 ) of patients with MS were significantly increased compared to the control.Serum concentration of leptin[(26.38±10.85)ng/ml vs (19.63 ±6.27)ng/ml,t =2.22,P ＜0.05],IL-18[(309.40 ±49.77)pg/ml vs (291.80 ±39.21)pg/ml,t =2.33,P ＜0.05],CRP[ (2.73 ±0.72)ng/ml vs (2.28 ±0.38)ng/ml,t =3.41,P ＜0.01 ],sICAM-1 [ (333.85 ±55.97) ng/ml vs (306.24 ±50.55) ng/ml,t =3.16,P ＜0.01],and HOMA-IR(4.53 ±2.39 vs 2.89 ±0.69,t =2.87,P ＜0.01 ) were significantly decreased after training for 12 weeks.ConclusionsAerobic exercise is one of the effective treatments of patients with MS.Its underlying mechanism may be associated with reduction of serum inflammatory adipokine concentration,and improvement of vascular endothelial function and insulin resistance.

Objective To evaluate retrospectively the efficacy of cistema magna plastic repair in the treatment of Chiari malformation complicated with syringomyelia Methods Fifty-one patients suffered from Chiari malformation complicated with syringomyelia were treated in our department from May 2004 to October 2009. Seventeen patients received cistema magna plastic repairment (the decompression of posterior cranial fossa, duraplastic repair,resection of hernia below cerebellar tonsil and separation of adherence of arachnoid membrane). Results Clinical symptoms disappeared or improved in 15 cases (effective rate of 90%). MRI showed tonsillar herniation disappeared,syringomyelia narrow. MRI showed cistema magna plastic repair, syringomyelia disappeared or significantly thinned and spinal cord subarachnoid space widened. Effective treatment obtained in 12 cases (effective rate 70%). Conclusions The efficiency of Cistern magna plastic repair treating Chiari malformation with syringomyelia is satisfied.

Despite a combination of all available treatment, the mortality of liver failure is very high,especially in children patients. Artificial liver support methods have been tested for over 50 years. Standard techniques of blood purification like hemodialysis, adsorption, hemo or plasma filtration as well as bioreactorbased approaches using liver cells or tissues have been used. It' s believed that the damaged liver has the ability to return to normal. Artificial liver support systems are expected to be useful for temporary support of liver function. If the liver does not regenerate to normal functions, an artificial liver support system may be useful as a bridge to liver transplantation. In conclusion, artificial liver support method appears to be a reliable therapy for advanced liver diseases and has significantly decreased the mortality of liver failure. Artificial liver support system has been used in children patients as well, but it still needs more researches.