Objective To explore the effects of resistance exercise on intradialytic blood pressure variability and the lowest blood pres-sure. Methods From September, 2015 to March, 2016, 80 patients with intradialytic hypotension frequently during maintenance hemodialy-sis were included, and divided into control group (n=40) and intervention group (n=40) by drawing lots. Both groups accepted routine nurs-ing, while the intervention group accepted resistance exercise during hemodialysis. The coefficient of variation (CV) of blood pressure and the lowest blood pressure were compared twelve weeks later. Results The CV of systolic blood pressure was less in the intervention group than in the control group (t=-4.356, P<0.001), while the lowest blood pressure, both systolic and diastolic, were more (t>4.122, P<0.001). Conclusion Resistance exercise may reduce the intradialytic systolic blood pressure variability and increase the lowest blood pressure in pa-tients with frequent intradialytic hypotension.

AIM To observe the inhibitory effects of tricin on the airway inflammation in low concentration LPS induced asthma mice.METHODS The model of asthma mice with airway inflammation was induced by low concentration LPS plus OVA.There were four groups:blank control group,asthma model group,tricin treatment group and dexamethasone (positive drug) treatment group.The levels of inflammatory factors,including NO,TNF-α and IL-1β,in bronchoalveolar lavage fluid (BALF) were detected by ELISA;the pathology of lung tissue was observed by HE staining;the mRNA and protein expressions of TLR4,MyD88 and NF-κB p65 in alveolar macrophages were detected using real-time quantitative PCR (RT-PCR) and Western blot.RESULTS Tricin could significantly decrease the levels of NO,TNF-α and IL-1β in BALF of asthma mice and improve lung inflammation.It could also down-regulate the relative mRNA and protein expressions of TLR4,MyD88 and NF-κB p65.CONCLUSION Tricin has inhibitory effects on airway inflammation in asthma mice,whose mechanism may be related to the intervention of TLR4/MyD88/NF-κB pathway.

目的比较国产重组链激酶与尿激酶静脉溶栓治疗老年人急性心肌梗死(AMI)的临床疗效。方法97例60岁以上AMI患者随机分为链激酶组(54例)和尿激酶组(43例)进行静脉溶栓治疗 ,比较两组患者的疗效及不良反应。结果冠状动脉血管开通率链激酶组75.9%,尿激酶组55.8%;并发症中,血痰:链激酶组5.6%,尿激酶组4.7%;血尿:链激酶组1.9%,尿激酶组2.3%;局部出血:链激酶组7.4%,尿激酶组4.7%;低血压:链激酶组3.7%,尿激酶组4.7%;过敏反应:链激酶组1.9%,尿激酶组2.3%;5周预后两组患者无显著性差异。结论国产链激酶静脉溶栓治疗老年人急性心肌梗死的冠状动脉血管开通率较尿激酶高,不良反应发生率与后者无显著性差异,可作为老年急性心肌梗死患者静脉溶栓治疗的首选药物。

SF-36 scale has been widely accepted because of its objectivity and scientificity. However, until now its application in TCM treatment for rheumatoid arthritis is not common. This article discussed the significance of SF-36 scale as the main content of life quality assessment in the efficacy evaluation system of TCM treatment for rheumatoid arthritis, which can provide certain references for the promotion of the application in this field.

The recent studies have shown a significant relationship between persistent organichorine pollutants(POCPs) and semen quality. The biological characters and source of POCPs, the effect mechanisms of POCPs on semen quality, sperm structure and function were reviewed in this paper. The epidemiological evidences for the reproductive disturbance of men caused by POCPs were discussed and the research direction in the future was pointed out.

OBJECTIVE To discuss the nosocomial infection risk factors and preventive strategies in human assisted reproductive technology(ART)laboratory.METHODS The nosocomial infection risk factors in ART laboratory were analyzed,and the corresponding measures were set up.RESULTS In ART laboratory,there were nosocomial infection risk factors existing in management system,preventive process,condition of laboratory,technical program and garbage management.Corresponding measures were established to control the risk of nosocomial infection.CONCLUSIONS The nosocomial infection in ART laboratory can effectively be prevented through establishment of perfect control system,strict operation of the rules and improving technical programs.

Objective:To construct a small interfering RNA(siRNA)expression vector(psiRNA-VEGFR-3)targeting vascular endothelial growth factor receptor 3(VEGFR-3)and to investigate the effects of VEGFR-3 siRNA on the adherence and invasion of human colon cancer cells.Methods:A siRNA expression vector(psiRNA-VEGFR-3)targeting VEGFR-3 were constructed and was used to transfect LoVo cells via lipofectamine 2000.The mRNA and protein expression of VEGFR-3 were examined after transfection by reverse transcriptase polymerase chain reaction(RT-PCR)and Western blotting,respectively.The tumor adhesion ability was detected by cell-matrix adhesion experiment and the invasion ability of tumor cells was evaluated by millicell chamber model.Results:The VEGFR-3 siRNA expression vector was successfully constructed.The expression of VEGFR-3 mRNA and protein was inhibited after psiRNA-VEGFR-3 transfection.Seventy-two hours after psiRNA-VEGFR-3 transfection,Western blotting assay showed that the expression of VEGFR-3 protein was decreased from(1.26?0.19)to(0.39 s0.12)(P

Objective To research the effect of atractylodes macrocephala koidz on immune function of tumor-bearing mice.Methods With S_ 180 bearing C_ 57 BL/6 mice as model.Effects of atractylodes macrocephala koidz on tumor weight and immunological function of spleen were cells systematically investigated.Results Atractylodes macrocephala koidz could obviously restore immune function of tumor-bearing mice reduced by chemiotherapy,promote proliferation of activated T cell and interleukin-2(IL-2) levels of tumor-bearing mice.Conclusion Atractylodes macrocephala koidz can reverse the immunological inhibition caused by tumor antigen and chemiotherapy.

MOS 36-Item Short-Form Health Survey has been widely recognized, but the application in the field of traditional Chinese medicine rheumatism was less. This article aimed to summarize the application of MOS 36-Item Short-Form Health Survey in Chinese medicine for rheumatism. This may provide certain reference for the future application.