OBJECTIVE:To provide reference for the improvement of pharmaceutical administration in secondary general hospital.METHODS:The problem existing in the pharmaceutical administration in 2 tertiary and 6 secondary general hospitals were evaluated in accordance with the "Practice Regulations of Guizhou Hospital Management Year Evaluation Guidance(Trial)";and the measures for its improvement were put forward.RESULTS & CONCLUSIONS:The hardware construction for the pharmaceutical administration in secondary general hospital can meet the requirements basically,however,the management level is still low and there is long way to go before the management meeting the requirements of evaluation guidance in respect of the implementation of clinical pharmacy,rational use of antibacterials,and the management of special drugs.It is necessary to strengthen the connotation construction,standardize the management and promote the continued development of hospital pharmaceutical management.

The humanistic quality education of undergraduate clinical medical students is a system of education throughout the whole process of medical education.Some aspects include new career planning education,medical humanities quality courses,social practice,professional courses,clinical practice and evaluation of humanistic quality education need to design and control,which are necessary to achieve a good education results.

Objective:Two experiments were performed to research the effects of visual field factor on pseudoneglect and to test the theories about neglect and pseudoneglect.Methods:Experiment 1 employed the landmark task and greyscales task in tachistoscopic and forced-choice conditions.Experiment 2 employed the greyscales task and tachistoscopic visual three-field technique.Results:Experiment 1 manifested that greyscales had no crossover effect;the length factor had effect on the greyscales task as the landmark task,but it only affected the bias magnitude,not the error direction.Experiment 2 indicated that the main effect of visual field was significant:when the greyscales were presented in the middle or right,pseudoneglect manifested,but when in the left,pseudoneglect vanished.Conclusion:The results provide evidence supporting the hypothesis that the perceptual distortion derives from the attentional process.

Objective To evaluate the impact of integrated information management platform on life style of diabetic patients. Methods A total of 84 diabetic patients were assigned to the intervention group and the control group by random digits table method with 42 cases each. All patients were in the hospital and after discharge given conventional three-tier management model. The intervention group was given comprehensive information management platform, three-tier management model mediated on this basis. The life style, fasting blood glucose, glycated hemoglobin were collected and compared between the two groups before and after intervention. Results After 9 months of intervention, the dietary pattern of the intervention group was more in line with the Chinese Dietetic Association's recommended dietary standard, in which staple food decreased from (343.90 ± 225.61) g before intervention to (311.71 ± 144.46) g, and meat decreased from (61.52 ± 59.73) g before intervention to (50.07 ± 36.16) g, and the lipid content decreased from (32.67 ± 21.31) g before intervention to (28.57 ± 19.52) g, compared with the control group (376.49 ± 129.58), (73.90 ± 55.15), (45.78 ± 20.03) g, there were significant differences(t =2.076, 2.278, 3.841, all P<0.05). The number of physical exercises increased from 30 before intervention to 37 cases, the number of moderate exercise increased from 12 cases before intervention to 20 cases, and the median of exercise scores increased from 11.000 (26.500) points before intervention to 33.000 (23.500) points, compared with the control group 15.000(18.000) points, there was significant differences (Z =3.687, P<0.01). The fasting blood glucose, glycated hemoglobin were (7.73 ± 1.31) mmol/L, (6.75 ±1.81)% after intervention and 8.000(2.200) mmol/L, 7.600(1.600)%before intervention in the intervention group, compared with the control group (8.60 ± 2.25) mmol/L, (8.81 ± 2.63)%, there were significant differences(t =2.111, 4.062, P<0.05 or 0.01). Conclusions Integrated information management platform management mode three-mediated diabetes may urge to improve the existing way of life, better control of blood sugar.

Purpose: To study the effect of personality on the mental adjustment of breast cancer patients during operation. Methods: Forty three breast cancer patients were examined by the Eysenck Personality Questionnaire (EPQ) for their personality before operation, and by the Mental Adjustment to Cancer Scale ( MAC) for their mental adjustment reaction before and after operation. Results: ANOVA repeated analysis revealed that the patients characterized by high Psychoticism showed higher scores on Fatalism, and the patients characterized by low Lie showed higher Hopelessness during operation. Conclusions: In the treatment of breast cancer patients, it is necessary to give appropriate psychological treatment according to the patients's individual characteristics.

Objective To explore the rule of distribution and the expression significance of neuronal nitric oxide synthase(nNOS),paired box 3(Pax3) and connexin 43(Cx43) proteins in the early developing spinal cord of human embryos. Methods During the 5th to 16th weeks of human gestation,the expression productions of nNOS,Pax3 and Cx43 proteins were investigated in the anterior horn of spinal cord using the immunohistochemical methods. Results During the 5th to 16th weeks of human gestation,the immunohistochemical staining intensities of both nNOS and Pax3 in the anterior horn neurons of spinal cord increased from weakly to strongly positive staining.During the 5th to 12th weeks of human gestation,the immunohistochemical negative staining of Cx43 protein was observed in the anterior horn neurons of spinal cord,while the positive staining was observed from the 13th to 16th weeks.Conclusion nNOS,Pax3 and Cx43 proteins are related to the growth and development of spinal cord in human embryos.

Objective To investigate the effect and mechanism of adenovirus vector mediated SOCS 3 gene transfection in CD4+ Th cell differentiation and expression of inflammatory cytokines of mouse .Methods The CD4+ Th cells were isolated from spleen of C57bl/6 mouse and cultured .Ad‐SOCS3 were transfected into the CD4+ Th cells .PHA was used for culturing with the CD4+ Th cells .RT‐PCR were used to detect the mRNA expression ,and Western blot were used to detect the protein expression of cytokines .Results Compared with the control group ,the gene and protein expression of T‐bet ,IL‐2 ,IFN‐γ,STAT4 and IL‐12Rβ2 in the transfected group were significantly down‐regulated ,the gene and protein expression of SOCS3 ,GATA‐3 ,IL‐4 ,IL‐6 ,IL‐10 and STAT6 were significantly up‐regulated(P<0 .01) .Conclusion The results indicate that SOCS3 gene transfection can up‐regu‐late SOCS3 mRNA and protein expression in the CD4+ Th cells ,down‐regulate the JAK/STAT pathway ,inhibition of Th1 cell dif‐ferentiation ,and down regulation of inflammatory cytokine gene and protein expression ,and indirectly promote Th2 cell differentia‐tion ,and up the corresponding inflammatory cytokine gene and protein expression .

Objective To investigate the incidence of pain for the.elderly with dementia in our country.Methods The Chinese version of Doloplus-2 was used to assess pain in 103 patients with dementia.Results One or more specific diseases may cause pain in 94 patients,degeneration of bone and joint top of the list;69 patients with pain score geater than or equal to 5 points,the incidence of pain as much as 67% .Older persons in different age groups the incidence of pain is different,with the age increased the incidence of pain increased;different older age groups pain scores had no significant difference.Conclusion Pain in patients with dementia should be of great importance to the medical staff and give full play to the nursing staff in pain management.

Objective To study the effect of dexamethasone on pulmonary fibrosis model induced by bleomycin in rats and the expression of STAT1 and PDGF in lung tissue,and to discuss the possible mechanism.Methods Forty-five Wistar rats were randomly divided into three groups(15 in each group).They were dexamethasone group(DXM group),bleomycin group(BLM group) and control group(NS group):① The DEX group were intratracheally instilled with belomycin(BLM)(5mg/kg,in 1ml 0.9% NaCl solution),and then were treated with dexamethasone 3mg/kg via celiac injection daily;② BLM group were intratracheally instilled with BLM(5mg/kg),and then were treated with saline 3mg/kg via celiac injection daily;③ NS group were intratracheally instilled with saline(5mg/kg),and then were treated with saline 3mg/kg via celiac injection daily.Five rats in each group were sacrificed at 7,14,and 28 days after intratrachel instillation.Histological changes of the lungs were evaluated by HE stain.The bronchoalveolar lavage fluid(BALF) of right lung was gotten and the cells counting as well as differentiation were figured out.The expression of STAT1 and PDGF protein was assessed by immunohistochemistry.Results(1) The total number of inflammatory cells in BALF in BLM group was the highest at day 7 and diminished at day 14 and 28,which was significant different compared with that of the NS group(P

BACKGROUND:Long-distance, large-range tracheal stenosis or defects are often seen in clinic, and laryngotracheal reconstruction is stil a difficult problem. OBJECTIVE:To investigate the effects of animal autologous cartilage transplantation in laryngotracheal reconstruction. METHODS:The cricoid cartilage and partial anterior tracheal wal from New Zealand rabbits were resected to prepare laryngotracheal defect models. Then, autologous costal perichondrium was taken for transplantation. After 8-24 weeks, surviving animals were sacrificed to observe the repair effects. RESULTS AND CONCLUSION:General observation showed that animals breathed and ate normaly, the implanted cartilage bonded tightly with the surrounding tissue, the wound healed wel without granulation tissue and scar formation, and there was a smooth inner surface covered by mucosa in the lumen. Under the light microscope, there was some mucosa generating at the wound site, and some fibroblasts and striated muscle cels existed in the outer layer, with a smal amount of new cartilage formation. There was also a linking between chondrocytes and muscle cels. These findings indicate that autologous cartilage transplantation can be applied for laryngotracheal reconstruction in animals, which has a good effect.