After a description of the development of massive MOOC in domestic biomedicine and its characteris-tics, the major advantages and disadvantages of MOOC were analyzed in aspects of its copyright , guiding role of teachers, course experiments, and independent study of students, the application of MOOC in medical libraries was elaborated with 4 suggestions put forward for the development of MOOC in medical libraries.

Papers on linked data published in foreign countries from 2005 to 2013 were analyzed, showing that the research of linked data in foreign countries is in its introduction period on the subject growth curve, the number of related literatures tends to increase, with a number of classical literatures and core researcher groups formed.At present, the research is focused on the theory, implementation and application of linked data.

Objective To evaluate the clinical effects and safety when adopt smoothing liver and invigorating spleen treatment to cure diarrhea-predominant irritable bowel syndrome (D-IBS) characterized by liver stagnation with spleen deficiency.Methods 71 patients met the inclusion criteria of D-IBS were randomly divided into the treatment group(36 cases)and control group(35 cases),the treatment group used Shugan Jianpi therapy,traditional Chinese medicine Tongxieyao Fang and additive Shenlingbaishu Decoction; the control group taking Lactobacillus Complex Capsules treatment.Two groups of the time of taking medicine for 4 weeks.Observation and analysis of comprehensive effects and D-IBS symptom score before and after treatment.Results There was no statistical significance in the two groups before treatment,symptom total score difference,after the treatment group and the control group of symptom score were (4.83 ± 3.30),(7.00 ± 3.96),with a significant difference between the two groups (t =2.51,P ＜ 0.05) ; the total effective rate of treatment group was 91.67％,which was higher than 68.57 ％ in the control group(x2 =5.98,P ＜ 0.05).Conclusion The adoption of the smoothing liver and invigorating spleen treatment characterized by the use of Tong Xie Yao Fang and additive ShenLingBaiZhu decoction to cure D-IBS patients with liver stagnation and spleen deficiency has a relatively satisfactory clinical curative effect.

The distribution features of studies on reading popularization in CNKI-covered CSSCI papers were demonstrated from the aspects of their annual distribution, core authors and institution co-occurrence network by bibliometric, visualization and contents analysis.The study hot spots in the two development periods of reading popularization were displayed in the form of knowledge map with the study contents assessed in brief in order provide certain reference for the creative development of reading popularization theories and practice.

Objective To evaluate the effect of retroperitoneal laparoscopic ureterolithotomy (RLUL),ureteroscopy(URS),microchannel percutaneous nephrolithotomy (mPCNL) in the treatment of impacted upper ureteral calculi.Methods Clinical data of 105 cases with impacted upper ureteral calculi were retrospectively analyzed.The average residence time of stone in the same position was 8.6 (2-49) months and the average stone surface area were 171 (71-361)mm2 in 41 cases received RLUL treatment.The average residence time of stone in the same position was 9.5 (2-47) months and the average stone surface area were 159 (71-342)mm2 in 29 cases received URS treatment.The average residence time of stone in the same position was 8.9 (2-51) months and the average stone surface area were 165(71-353)mm2 in 35 cases received mPCNL treatment.Results In the RLUL group,surgery was successful in all patients and the stone-free rate was 100％ ;In the URS group,the surgery success rate was 93.1％ and the stone-free rate 1 month later was 92.6％ ;In the mPCNL group,the surgery success rate was 97.1％ and the stone-free rate 1 month later was 97.0％.The operation time in the URS group (mean 65 min,ranged 45-95 min)was longer than that in the RLUL(mean 46 min,ranged 25-70 min) and mPCNL(mean 51 min,ranged 39-80 min)groups (P＜0.05).The hospital stay in the URS group (mean 5.1 days,ranged 4-12 days) was shorter than that in the RLUL(mean 7.9 days,ranged 6-11 days) and mPCNL(mean 8.1 days,ranged 5-18 days)groups (P ＜ 0.05).The operation time and the hospital stay had no significant differences between the RLUL group and mPCNL group (P ＞ 0.05).The surgery success rate,stone-free rate and the serious complications of the three groups had no significant differences (P ＞ 0.05).Conclusion The operation time of URS is shorter,but postoperative recovery is faster than that of RLUL and mPCNL groups.Although the incidence of serious complications has no statistically significant differences among the three treatments,but URS and mPCNL surgery have the potential risk of serious complications.RLUL does not increase the difficulty of operation,has less serious complications,and is a remedy for failure in URS and mPCNL operation.

The factors influencing the integration of MOOC and information literacy education in academic libraries were divided into objective factor, subjective factor and social factor according to their connotation and significance. Certain measures for their integration were proposed, such as strengthening network construction, perfecting literacy education systems, and carrying out systemic training.Integration of MOOC and information literacy education in academic libraries can improve information service, promote wide application of MOOC and information literacy ed-ucation in academic libraries.

The glucose metabolism pathways including glycolysis and oxidative phosphorylation in vivo.The metabolism of tumor cells depends on glycolysis,which enhances the adaptability of tumor cells to the microenvironment and promotes the proliferation of tumor cells,which is called Warburg effect.Arsenic is one of the chemical pollutants,which is widely distributed in natural environment.International agency for research on cancer (IARC) has made it clear that arsenic and its compounds are carcinogens.However,the mechanism of carcinogenesis induced by arsenic still remains obscure.Recently,researchers have found that Warburg effect plays an important role in the process of arsenic carcinogenesis.In this paper,we have reviewed the definition and function of glycolysis,its relationship with inflammation and tumorigenesis,and the role of Warburg effect in arsenic carcinogenesis.

Objective:To explore the relation of college students' life events,cognitive emotion regulation and life satisfaction.Methods:296 college students in Changchun completed the life events scale,emotion regulation questionnaire and life satisfaction scale.Results:①Academic pressure,inter-personal relationship and punishment were life events which influenced the most of student's life satisfaction;②Life events were positively correlated with cognitive emotion regulation(r=0.177,P

Acute Pancreatitis Classification Working Group published Classification of Acute Pancreatitis-2012:Revision of the Atlanta Classification and Definitions by International Consensus in 2012,which redefined the diagnosis,severity,local complication,local infection of acute pancreatitis (AP).Under the guidance of revised Atlanta classification (RAC),the constituent ratio of severe acute pancreatitis (SAP) decreases significantly,which is between 3.7％ ～ 25.4％,and less than 10.0％ is reported in most researches.The mortality of SAP is between 10.0％ ～ 52.9％,and more than 20％ is observed in most publications.The constituent ratio of mild severe acute pancreatitis (MSAP) is between 10.9％ ～ 40.1％,the mortality is between 0 ～ 4.8％,and the incidence rate of organ failure is between 4.6％ ～ 34.0％.The percentage of patients with SAP who need ICU care and surgery intervention is higher than that of MSAP,and the total hospital stay of SAP are longer than that of MSAP.RAC could better reflect the severity and predict the outcome of AP than Atlanta classification published in 1992,but RAC also has some potential limitations.For example,the “local infection” is not included in this classification.This paper veviewed the relavent issues.

Biology-related disciplines in medical school of comprehensive university are cur-rently confronted with some difficulties, including unclear position and indistinguishable characteris-tics. In this paper, we proposed that biology-related disciplines in medical school of comprehensive university should center on disease research, emphasize medical feature and give full play to its tech-nical advantage thus to provide technical support for basic medicine and clinical medicine. Mean-while, sources of multiple disciplines should be effectively integrated by breaking through the limitation of discipline and administrative system. An interdisciplinary molecular medicine platform was built up for researching and teaching.