Proceeding from such perspectives as the development of medical science and technology,the prevention and treatment of diseases,and the needs of hospitals for self-development,the paper discusses the significance of building research-oriented hospitals.It also expounds the concept and intensional features of research-oriented hospitals in light of the successful experience of specialty hospitals that have developed through science and education,the development strategies and measures of research-oriented enterprises and universities,and the unique features of hospitals.At the same time the paper puts forward suggestions for appropriately handling certain relationships in the building of research-oriented hospitals.

Anti-Bacterial Agents ; administration & dosage ; adverse effects ; blood ; Bacteremia ; drug therapy ; Body Weight ; Drug Dosage Calculations ; Female ; Gentamicins ; administration & dosage ; adverse effects ; blood ; Gestational Age ; Humans ; Infant, Newborn ; Injections, Intramuscular ; Male

Ampicillin ; pharmacology ; therapeutic use ; Cellulitis ; drug therapy ; prevention & control ; Comorbidity ; Endocarditis ; drug therapy ; prevention & control ; Female ; Humans ; Infant ; Infant, Low Birth Weight ; Infant, Newborn ; Recurrence ; Sepsis ; drug therapy ; prevention & control ; Streptococcal Infections ; drug therapy ; physiopathology ; Streptococcus agalactiae ; pathogenicity

Objective To compare the results of 3 methods to treat complete dislocation of acromioclavicular joint. Methods Three different surgical techniques were employed: Dewars procedure (in Group A of 32 cases),tension band wiring (in Group A of 44 cases), and Wolter plate fixation (in Group A of 20 cases). There were 81 males and 15 females, or totally 85 cases of acute dislocation and 11 chronic dislocation. Results 96 cases were followed up with an average period of 50 months. Acording to karlssons standards, in group A, 26 patients were assessed as good, 5 as fair and 1 as poor. In group B, 20 patients were assessed as good, 13 as fair and 11 as poor. In group C, 15 patients were assessed as good, 4 as fair and 1 as poor. There were differences between A and B, C and B. But there werent statistic differences between A and C. Conclusion The Dawers procedure is believed to be a good, simple and safe method to treat acromioclavicular joint dislocation, with no need of a second operation to remove the implant and with less complications.

By analyzing the situation that large general hospitals face at present in their development and the background of reform in the system of overall responsibility by the attending physician in the hospital, the authors offer an account of the guiding ideology for large general hospitals to adopt the system of overall responsibility by the attending physician, the specific steps taken and the initial results attained. They also discuss the impact of the system of overall responsibility by the attending physician on the hospital from the perspectives of human resources, technological innovation, managerial system, and information system. The positive significance of the system of overall responsibility by the attending physician in the management of the hospital reform is also identified.

CDFI was performed in 20 patients with acute upper ureteral obstruction secondary to ureteral stone. Intrarenal flow of unilateral obstructed kidneys and contralateral nonobstructed kidneys was observed. Resistive index (RI) of intrarenal arteries was measured. The results showed that RI of intrarenal arteries in unilateral obstruted kidneys was elevated during acute upper ureteral obstruction with renal colic. The RI in contralateral nonobstructed kidneys did not change. Statistically significant differences were noticed in the groups of normal versus obstructed kidneys (P

The identification and classification of Thermus to Thermales is revie wed. Up to now, the order Thermales is consist of only one family Thermaceae, w h ich includes 4 genera with 14 valid species about 50 strains, and with 4 unvalid spcecies and more than 50 strains unidentified. The morphology, physiology, G+ C mol%, DND hybridization, fatty acid components, 16S rRNA alignment and secondar y structure analyses have been tools for the taxonomy of Thermales.

Diagnostic Errors ; Female ; Humans ; Middle Aged ; Thyroid Nodule ; diagnostic imaging ; Ultrasonography ; Zenker Diverticulum ; diagnostic imaging

BACKGROUND:Exendin can regulate blood glucose, blood lipid and blood pressure, exert anti-inflammation and anti-oxidative stress effects, improve myocardial infarction and heart failure, and protect heart vessels. However, the effect on the apoptosis of cardiac muscle cels after ischemia/reperfusion injury remains unclear. OBJECTIVE:To observe the effects of Exendin-4 pretreatment on the cardiomyocyte apoptosis and the expression of Bcl-2 and Bax in rats with myocardial ischemia/reperfusion injury. METHODS:The myocardial ischemia/reperfusion injury model was established in rats and then received Exendin-4 pretreatment. Ischemia/reperfusion group and sham operation group were set. RESULTS AND CONCLUSION:Immunohistochemical staining, TUNEL and reverse transcriptase-polymerase chain reaction results showed that Bcl-2 protein and mRNA expression levels in the Exendin-4 group were significantly increased (P < 0.05), while Bax protein and mRNA expression levels were significantly decreased compared with ischemia/reperfusion group (P < 0.05). In addition, apoptosis index was more significantly decreased in the Exendin-4 group than in the ischemia/reperfusion group (P < 0.05). Exendin-4 can protect rat heart muscle against ischemia/reperfusion injury and effectively inhibit the apoptosis of cardiomyocytes, and the underlying mechanism is mediated by up-regulating Bcl-2 expression and down-regulating Bax expression.

Objective To evaluate the clinicopathological features,treatments and prognostic factors of male breast cancer (MBC) patients.Methods Clinical data of 102 MBC patients with histopathology confirmation at Tianjin Medical University Cancer Hospital were retrospectively analyzed.Results All 102 cases got follow-up.The follow-up rate was 100％.The follow-up period was 3-279 months.The mean follow-up period was 65 months.During the follow-up period,recurrence was found in 21 cases,metastasis occurred in 28 cases (including pulmonary metastasis in 8,osseous metastasis in 7,hepatic metastasis in 9,brain metastasis in 3,and soft tissues and adrenal gland metastasis in 1).The 5-year disease free survival rate was 54.3％ and the 5-year overall survival rate was 72.8％.Univariate analysis showed that tumor size,axillary lymph node status,TNM stage,chemotherapy influenced the disease free and overall survival.Multivariate Cox regression shows that axillary lymph node status (P =0.085)was the independent prognostic factor of disease free survival for MBC.Tumor size(P =0.041)and axillary lymph node (P =0.024) status were independent prognostic factors of overall survival for MBC.Conclusions Early diagnosis and comprehensive treatment strategy consisting of radical mastectomy is essential to improve the survival of patients with MBC.