OBJECTIVE： To discuss about the key and entrance points of the development strategy of Chinese materia medica in the new century.METHODS： Some important items,such as difficult problems which Chinese materia medica facing to at present,new way to research into its effective substance bases,innovation on the theory and “ molecular targets” of Chinese materia medica,were analyzed.RESULTS ＆ CONCLUSION： Chinese materia medica industry would become a most important pharmaceutical industry in China and really walk up to the whole world if traditional Chinese herb medicine supplies“ international language” for its exchange,qualitative and quantitative standards on judging the essence of its prescriptions and builds up its“ earmark” of Chinese materia medica industry.Based on the train of thought of this paper,suggestions how to promote the development of Chinese materia medica in the new century are put forward.

Accurate alignment of knee implants is essential for the success of total knee replacemem.Recently,computer-aided navigation systems have become available,and the results showed more accurate and consistent installation of knee implants.The technology has evolved rapidly with widespread and continue to be developed.The current computer environmem and graphical user interface will become more user friendly and thus gain more widespread acceptance among experienced surgeons With this technology growing and systems evolving,computerized navigation will become the standard of care in knee reconstructive surgery.The key of future studies is to evove less invasive tracker anchoring systems,electronic balancers and computerized saws.A hybrid technique between image-based and image-free methods may develop to produce image-enhanced navigation.It should be an intermediary step between current technology and a fully robotic system.

Since the first session of Chinese anti-inflammatory immunopharmacological society in 1982,many breakthroughs of immunological research have been made in western countries,such as identification of pathogens by natural immune cells,regulation of immune response,lymphocyte differ?entiation and development. At the same time,much progress has been achieved in anti-inflammatory and immunological research in China,especially in the field of basic scientific issues in immunology, frontier and hot topics,immunological mechanisms of major diseases and related drugs. The course of development of Chinese anti- inflammatory immunopharmacological research has experiences various stages,such as ″follow ″ in the past to ″work together ″ and to ″lead ″ in some research areas in today′s international immunology.

The cells sense direction is closely related with the proteins that contain PH (pleckstrin homology) domain. PH domain has been found in about 60 proteins, many of which could activate the sequent events of signal transduction via combining with the related binding sites on the surface of chematactic cel ls. The characteristics of this combining are: a.rapid and transient; b.It is only related to the concentration gradient of surroundings outside cells, whi ch is the base of spatial model; c.The distribution of the binding sites on th e cell membrane changes when the researchers altered the position of the chemoat tractant. This is the base of temporal model. To deeply investigate the effects of all kinds of proteins which contain PH domain on cells sense of direction will greatly promote the research of this field, and hence, has great theoretica l significance.

AIM:To study of effects of Panax notoginsengnoside(PnGL) on neutrophil(Neu) functions in carrageenin(Car) induced subcutaneous air-vesicle synovitis in rats and its mechanisms METHODS:Rat air-vesicle synovitis model was established with sc Car(25mg/kg) Neu count,the phagocytosis of Neu,the realease of O2 ?- from Neu and the level of Neu-i were measured with test tube diluting method,staphylococcus aureus phagocytosis method,cytochrome C reduction method and Fura-2 fluorescence technique respectively RESULTS:At 12h after Car used,Neu count of exudates elevated,phagocytosis rate and index of Neu and the release of O2 ?- from Neu increased obviously,suggesting that Neu was in an activated state Mea_nwhile,the level of Neu-i elevated significantly PnGL 60～240mg/kg ip,30min before and 6h after Car sc,reduced Neu count of exudates,inhibited phagocytosis functions and the increase of i level of Neu in a dose-dependent manner There was a significant correlation between the reduction of Neu-i and the inhibition of Neu phagocytosis functions and the release of O2 ?- from Neu Dexamethason had similar effects on Neu functions to PnGL,but with no effect on the level of Neu-i CONCLUSION:The reduction of Neu-i level and the subsequent inhibition of Neu functions is one of the important anti-inflammatory mechanisms of PnGL,which is different from that of Dex

Objective To compare the effect of low-temperature plasma ablation and YAG laser treatment on persistent allergic rhinitis(PAR) after septoplasty and to seek adjunct surgical procedures to tackle PAR.Methods Follow-up was performed three years after randomized grouping on PAR patients ( Low-temperature plasma ablation group 127 cases and YAG laser group 1 18 cases).Visual Analog Scale (VAS) was used to evaluate symptoms,such as nasal congestion,running nose,sneezing,nasal itching,eye itching etc preoperatively and postoperatively in order to compare the treatment effectiveness and intergroup difference.Results The efficacy rate of Low-temperature plasma ablation group was 87.4％,and YAG laser group was 66.1％.The difference was statistically significant( x2 =15.74,P ＜ 0.01 ).The VAS scores for postoperative symptom relief in both groups were significantly different ( t =21.24,20.56,all P ＜ 0.0 1 ).Conclusion As an adjunct treatment approach,low-temperature plasma ablation was superior to YAG laser in the treatment of PAR with preferable safety.

At present,the main method for data process is to eliminate or save the data,and stale data is seldom reutilized.In this article,the author makes a method that using data warehouse to manage stale data.It can utilize the character of data warehouse to manage stale data and to find the rule in the stale data.

Objective To study the role of zymosan in and the effects of total saponin of Panax notoginseng (PNS) on the formation of foam cells originating from peritoneal macrophages. Methods The peritoneal macrophages of mice were cultured with zymosan, PNS and oxidized low density lipoprotein (ox-LDL) for 48 h. The shape of the foam cells was shown with the staining of red oil O dye. The content of total cholesterol (TC) in the foam cells was determined. The concentration of TNF? and IL-1 in the supernatant of the cell culture was measured. Results The TC content and the concentration of TNF-? and IL-1 were significantly higher in the zymosan group than in the PNS group. Conclusion Inflammation can accelerate the formation of foam cells through the pathway of inflammatory cytokines but PNS can reduce the formation with the inhibition of inflammation.

Aim Curcumol and Zedoary Turmeric Oil (ZTO) were prepared to liposome, which were used to study the anti-hepatoma effect, and its mechanism that was expected to provide theoretical support for the clinic anticarcinomal use of Zedoray Rhizome Abstracts.Methods Curcumol and ZTO were prepared to liposome by mechanical diffusion and ultrasonic techniques.Proliferation of HepG2 cell in vitro was observed with curcumol and ZTO by MTT assay. Apoptosis of cells was observed by staining with Hoechst 33258/PI and laser confocal scanning microscopy (LCSM). Expression of COX-2 mRNA and VEGF mRNA of HepG2 cell was investigated by RT-PCR.Results Envelopment ratios of curcumol liposome and ZTO liposome were 86.2% and 74.5%,respectively.Curcumol and ZTO inhibited proliferation of HepG2 cell by MTT assay.Compared with control group, Curcumol and ZTO increased the apoptosis rate of HepG2 cell significantly (P