Objective To explore the damage effect of formaldehyde on DNA in cells of rats. Methods 24 SD rats were randomly divided into 6 groups, formaldehyde (10, 20, 30, 40 mg/kg), distilled water and cyclophospho acetic acid (as the positive control) were given i.p. 24 hours after treatment. Comet Assay were used to detect DNA damage in the cells of the liver, kidney and lung. Results The DNA damage induced by formaldehyde was found in cells of the three organs and the significant dose-response relationship was demonstrated also. Conclusion Formaldehyde can induce DNA damage in cells of rats. The result of the present paper indicates once again that formaldehyde has genetic toxicity.

Objective To investigate the diagnosis and treatment of high-flow priapism. Methods Five cases of high-flow priapism (age range,18-54 years) were included.Their symptom was described as devoid of pain or tenderness, incompletely but constantly rigid of the penis which was able to increase rigidity with sexual stimulation.Blood taken from the corpora cavernosa showed an arterial blood sample in all the cases.Perineal color Doppler ultrasound findings included the presence of patent cavernous arteries and the focal area of high flow turbulence along the cavernous arteries in 4 cases.Contrast medium extravasating from a lacerated cavernous artery into surrounding erectile tissue lacunae was found when performing internal pudendal arteriography in all the cases.Initially,conservative therapy was attempted but was unsuccessful.Therefore superselective embolization of the proximal artery supplying arterial fistula was carried out in the 5 cases. Results After embolization the penile erection disappeared immediately.In 1 case,priapism recurred 12 h after the embolization and the second embolization was successful and the interval of complete detumescence was 5 to 42 d.The sexual function and erectile rigidity were normalized in 2 weeks to 4 months after embolization.The follow-up time was from 11 to 143 months.The sexual function was completely preserved in all the 5 cases with no recurrence of priapism. Conclusions Intracavernal blood gas analysis,color Doppler ultrasound and internal pudendal arteriography were effective means for the diagnosis of priapism.The effect of superselective embolization of the internal pudendal artery was satisfactory.

Objective To analyze the epidemiological characteristics of mumps in Inner Mongolia Autonomous Region from2015 to 2022,and provide decision making strategy for the control and prevention of mumps.Methods Using SPSS 26.0and Excel 2010 statistical software,the epidemiological statistical description and analysis of mumps cases in Inner Mongolia Autonomous Region from 2015 to 2022 were performed.Results A total of 16 018 cases of mumps were reported in Inner Mongolia Autonomous Region from 2015 to 2022,with an average annual incidence of 8. 274 5/100 000. All cities had reported cases,and the peak incidence was mainly concentrated from April to July and from September to December. The age of the affected population was mainly 0-14 years old,accounting for 90. 14% of the total number of cases,and the affected population mainly included students,preschool children and scattered children.Conclusion From 2015 to 2022,the incidence rate of mumps in Inner Mongolia Autonomous Region showed a downward trend,and the average annual incidence was lower than the national reported level. The epidemic showed an obvious seasonality,and students,kindergarten children and scattered children were the key groups for prevention and control. It is necessary to strengthen the surveillance,prevention and control of mumps in schools,kindergartens and other collective units,and continue to implement the immunization strategy of age-eligible children vaccinated with two doses of mumps-containing vaccine(MuCV).

The test after maintenance can remove such personal factors as bad installation,disqualification of parameter debugging,fault in pipeline,etc.It avoids some malpractice during the treatment.

Objective To explore the personnel framework strategy of multi-disciplinary treatment (MDT) for colorectal cancer. Methods Combined the characteristics of large public hospital, with recognized treatment pathway in international MDT for colorectal cancer and management of medical human resource, colorectal cancer MDT project team summarized a system of multi-disciplinary treatment-working for colorectal cancer of West China Hospital (MDT-CRC-WCH) by own management mechanism and subject feature. Results Based on the main four principles——whole, match, voluntary and interactive, MDT-CRC-WCH constructed reciprocation “concentric circle” with the team of directors, coordinators, colorectal surgeons, related professors, nursing and other assistants.Conclusion With construction of multi-layers, MDT for colorectal cancer is completing MDT personnel framework and suitable layers relation. And how to construct prolong active and innovative system of MDT human resource management needed more research.

Objective To explore the whole constructive conception and organization structure strategy of multi-disciplinary team (MDT) for colorectal cancer (CRC). Methods Combined the characteristics of large public hospital, with recognized treatment pathway in MDT for CRC and the way of medical project construction, MDT for CRC project team summarized a system of MDT for CRC of West China Hospital (MDT-CRC-WCH) by own characteristics and subject feature. Results MDT for CRC summarized the 5 basic characteristics about profession, classification, interaction, optimization and fast. The project has the core competencies: system new operation types for colorectal cancer and volunteer culture. By the matrix organization structure, MDT set the main departments: database team, follow-up team, nursing team and public team. Conclusion With effective MDT whole construction and suitable organization structure, MDT will develop in long time.

Objective The article explained how to build the data system and its running strategy in the mode of multi-disciplinary team (MDT) for colorectal carcinoma. Methods It illuminated the cause of the data system building, also described the essential composition of the data system and how to support the running of the data system, and it discussed the value feedback of the data system, lastly the author proposed the prospect of the data system building. Results The data system could work normally through consultation of doctors, follow-up, clinical support and appropriate implement of construction of information flow-sheet in colorectal carcinoma MDT mode. Conclusion As the foundation of colorectal carcinoma MDT, data system could show both medical and social value through change of medical mode.

The implementation,operation and maintenance of building have huge impacts on environment and human health,however,the research about quantitative assessment of damage to human health for construction project still does not appear in China.Based on investigation in literatures about five LCA-based environmental impact assessment systems(EIA) systems,this paper concluded and compared the of health damage parts of the systems referred.Finally,some suggestions for establishing assessment systems of damage to human health especially in health damage indicators selection,characterization and weighting were proposed.

Objective To study the effect and the possible mechanism of delavirdine on muhidrng resist-ance-aasociated protein 2(MRAP2)-mediated multidrug resistance in LLC/cMOAT cells. Methods MTT assay was used to determine the effects of delavirdine on proliferation of LLC/CMV and LLC/cMOAT cells. The inhibitory effects of vincristine (VCR),cisplatin (DDP),adriamycin (ADM) and etoposide (VP-16) used alone or in combi-nation with delavirdine on the proliferation of LLC/CMV and LLC/cMOAT cells were evaluated by MTT assay. The cell cycle distribution, the apoptosis rate of the cells treated with different concentration of delavirdine and the intra-cellular concentration of ADM were determined by flow cytometry (FCM). Results Delavirdine at the concentration of 4 μmol/L and below showed no significant cytotoxicity to LLC/CMV and LLC/cMOAT cells. The resistance of LLC/cMOAT cells to VCB, VP-16, ADM and DDP were 9.58,1.11,2.98 and 3.96 folds of that of LLC/CMV cells. When 2 μmol/L delavirdine was added, the resistance was 5.21 and 2.55 folds respectively;when 4 μmol/L dela-virdine was edded,the resistance was 7.56 and 3.03 ,while 2,4 μmol/L delavirdine made no significant changes to the chemosensitivity of LLC/CMV cells to VCR and DDP(P>0.05). Cellular cycle analysis demonstrated that 0,6, 12,24 hours after co-cultured with delavirdine the amount of cells at G1 phase increased from(38.92±0.15)% to (56.87±2.23)%,(65.36±2.76)% and (74.77±5.06)%. The cell apoptosis rate increased from 1.77% to 17.45% and 28.52% when treated with delavirdine at 2,4 μmol/L and VCR for 24 h. When treated with 2,4 μmol/L delavirdine, ADM accumulation in LLC/cMOAT cells was enhanced significantly(P<0.05). Conclusion DLV can partially reverse the multidrng resistance of LLC/cMOAT cells, and the reverse effect correlates to the concentration. The possible mechanism may involve the growth arrest at G1, increasing of intracellular drug concen-tration and promoting apoptosis.

Objective To observe the clinical treatment effects of Qingkailing injection on Alzheimer's disease.Methods 84 patients with AD were randomly divided into a control group and a treatment group (n=42 cases,per group). The patients in both groups orally took 5 mg of donepezil hydrochloride every night. The Qingkailing injection of 60 ml was administrated by intravenous drip in addition to oral uptake of donepezil hydrochloride to the treatment group. The total treatment period of both groups was 20 weeks. The MMSE, ADL score, HS-CRP, IL-6, MDA and ox-LDL content and the clinical treatment results and differences in the two groups before and after the treatment were observed.Results After treatment, the serum HS-CRP (4.18 ± 0.38 mg/Lvs. 5.78 ± 0.53 mg/L,t=15.900), IL-6 (34.28 ± 4.33?g/L vs.44.75 ± 4.99?g/L,t=10.270), MDA (6.04 ± 0.98?mol/L vs.7.43 ± 0.69?mol/L,t=7.516), ox-LDL (62.87 ± 7.65?g/L vs.102.56 ± 9.81?g/L, t=26.677) content of the treatment group were significantly decreased than the control group (P<0.01). The total effective rate between the treatment group and the control group had significance difference (83.3%vs.  61.9%;χ2=4.850,P=0.028). The MMSE score in both groups after the treatment were higher than those in the same group(t value were 8.036, 7.475, respectively,P<0.01), ADL scores in both groups after treatment were lower than those before treatment(t value were 7.818, 5.960, respectively,P<0.01), but no significance difference between the two groups(t value were 1.633, 1.710,respectively,P value were 0.106, 0.091, respectively).Conclusion The treatment effect of Qingkailing injection on Alzheimer's disease was sound.