Objective To study if local implant of sustained-release 5-fluorouracil (5-Fu) and cisplatin (DDP) combined with radiotherapy can improve the treatment result of advanced and recurrent cervical cancer. Methods Forty-two patients with advanced (26 with stage Ⅲ) or recurrent (16) cervical cancer received local implant of sustained-release 5-Fu and DDP combined with radiotherapy ( group A), and 40 ( including 29 with stage Ⅲ and Ⅱ with recurrent cervical cancer) received radiotherapy alone during the same period as the control (group B). In group A, the pelvic external radiation was 45-55 Gy (including 25-30 Gy to the whole pelvis) over 6-7 weeks using 6-10 MV X-beams; 192Ir intracavity brachytherapy was 24-36 Gy in 4-6 fractions to the point "A", while the patients with Ⅲ A disease received 24-32 Gy in 3-4 fractions to 0.5 cm depth from the surface of vaginal mucosa; Sustained-release 5-Fu (200-400 rag) and DDP (40-80 mg) were implanted by puncture before and during the course of radiotherapy. In group B, the external beam radiation was as same as in group A, except that there was 8-12 Gy boosting to the local tumor in group B; The brachytherapy was 30-42 Gy to point "A", and those with ⅢA disease received 40-48 Gy to 0.5 cm depth from the surface of vaginal mucosa. Treatment efficacy and complications were compared be tween the two groups. Results In group A and B, the complete response rate (CR) was 69% and 30% (X2=12.50,P<0.01 ), respectively. The 3-year tumor-free survival rate was 62% and 25 % (X2=11.33,P<0.01), respectively. The time between the treatment and tumor response was shorter in group A then in group B. The toxicities of the bone marrow, the rectum and the bladder were similar between the two groups. Conclusions Local implant of sustained-release 5-Fu and DDP combined with radiotherapy could improve the results of patients with advanced or recurrent cervical cancer, without increasing the treatment toxicities.

ObjectiveTo approach the effect of early system rehabilitation training on the treatment of old age patients with proximal femoral fracture. Methods110 cases with surgical treatment of 75 years of age or older patients with proximal femoral fractures. according to whether receiving postoperative rehabilitation all the patients were divided into rehabilitation of 55 cases ,55 cases of control group;rehabilitation group were taken to early rehabilitation and training system, the control group received conventional rehabilitation. Clinical curative effect and complication rate of two groups were compared. ResultsAll patients were followed up for 8 months after operation,the rehabilitation group incidence of complications was 16.36 ％, significantly less than the control group, the incidence rate of 34.55％ ( P ＜ 0.05 ) ; functional evaluation of affected limb of rehabilitation group was 89.09 ％ higher than the 63.64％ in control group( P ＜0.05). ConclusionSurgical treatment of elderly hip fracture could decrease complication rate,improve functional evaluation of affected limb and clinical curative effect,could be used properly in clinic.

Fever model was made by intravenously injected leucocytic pyrogen(LP,EP). Chai Ge Jie Ji Tang CGJJT fluid was perfused into rabbits stomach by mouth. 65 New Zealand white rabbits were divided into four groups: (1) control group; (2) LP group; (3) CGJJT fluid group; (4) LP+ CGJJT fluid group. Effects of CGJJT fluid on LP fever and cAMP concentration in cerebrospinal fluid (CSF)were observed. The results obtained from our experiments showed that: (1) The rectal temperature of normal rabbits markedly affected by CGJJT fluid. (2) Febrile response of LP was significantly inhibited by CGJJT fluid (P

0.05). (2) Febrileresponse of LP was significantly inhibited by No.Ⅰ, No.Ⅱ, respectively. Concentrationof cAMP in CSF of LP group, 1 hour after injection of LP, was 140.94?51.74 pmol/ml, while that of the No.Ⅰ+ EP group was (83.48?8.11 pmol/ml) obviously lowerthan that of LP group (P

Primary squamous cell carcinoma of the thyroid gland is a rare malignant tumor with strong invasive ability and high malignancy.It is difficult to early diagnose and the radical surgery is hard.The prognosis is very poor with the median survival of six months approximately.The surgery is a primary treatment.For patients who can not be treated by surgery radiotherapy which is a feasble way.Respectively at a certain extent can improve the control rate,however chemotherapy does not show obvious advantages.

Yu Chang,a famous doctor in Qing dynasty,puts a high value on criterion, which is the most impor-tant characteristic in his medical moral thoughts. Based on the traditional medical moral, Yu Chang quoted Buddha into medicine and further expounded the medical moral criterion ( restrain the doctors by laws) referring to Buddhist commandment. This article analyzed the detailed medical moral criterion and requirements of carefulness,per-fection,honestyand pursuing the truththat mentioned in Medical Laws. Furthermore, it pointed out the es-sential features and significance of Yu Chang′s medical moral thoughts.

Horseradish peroxidase (HRP) was injected into the stellate ganglia of anesthetized cats. After 52-72 hour survival time, the animals were perfused and the spinal cord was processed by O-D technique to study the localization and segmental distribution of the sympathetic preganglionic neurons in the spinal cord which project to the stellate ganglia. HRP-labeled neurons in the spinal cord were located exclusively on the side of the injection and were found in five distinct areas:1. nucleus intermediolateralis pars principalis (ILp 76.08%).2. nucleus intermediolateralis pars funicularis (ILf 10.51%).3. anterior horn (AH 5.88%).4. nucleus intercalatus (IC 5.31%).5. nucleus intercalatus pars paraependymalis (ICpe 2.22%).Labeled cells were found in C_8-T_(10) spinal cord segments, with the highest accumulation of cells in T_3 segment. Furthermore, HRP-labeled ILp neurons were detected in C_8-T_(10) spinal cord segments, with a peak at T_3 segment; ILf neurons were seen in 8-T_9, with a peak at T_1 segment; AH neurons were seen in T_1-T_8, with a peak at T_2 segment; IC and ICpe neurons were seen in C_8-T_(10), with a peak at T_6 segment. Stellate ganglion; Sympathetic preganglionic neuron; Spinal cord; HRP method; Cat

Objective To summarize the experience of surgical of complete pulmonary venous connection in neonates,and analyze the risk factors.Methods Between June 2010 to June 2016,21 consecutive neonates under went surgical correction of total anomalous pulmonary venous connection.There were 15 males and 6 females at mean age 20d,and the mean weight was 3.5kg.There were 10 patients with supracardiac,of which 6 patients with intracardiac,4 patients with infracardiac,and 1 patients with mixed.Clinical variables possibly associated with death were examined using Logistic regression analysis.Results There were 4 operative deaths(19％),2 patients with supracardiac,1 patient with intracardiac,1 patient with infracardiac.2 were died of low cardiac output syndrome,and 2 died of pneumonia.Logistic regression analysis showed that preoperative pulmonary infection,anatomic classification,aortic clamping time,weight were risk factors of operation.Conclusion Total anomalous pulmonary venous connection operation in neonates can obtain satisfactory results.Preoperative pulmonary infection,anatomic classification,aortic clamping time,weight are risk factors for operation.

Objective To observe oxygenation status when different modes of mechanical ventilation were actualized during laparoscopic operations in obese patients. Methods Sixty obese patients for laparoscopy were divided into three groups with 20 patients in each group, receiving volume controlled ventilation (VCV Group), or pressure controlled ventilation (PCV Group), or pressure controlled ventilation with positive end-expiratory pressure (PCV+PEEP Group). Levels of pH value, PCO_2, PO_2/FiO_2, and Qs/Qt were measured at 30 min after pneumoperitoneum (T1), 60 min after pneumoperitoneum (T2), 30 min after extubation (T3), and 60 min after extubation (T4), respectively. Results The oxygenation index was significantly higher in the PCV+PEEP Group at T1 (429.35?51.88) and T4 (231.87?20.47) than in the VCV Group at T1 (346.15?54.48; q=6.771, P

Objective To investigate effects of three types of mechanical ventilation on oxygenation status in laparoscopic gastric banding for the treatment of morbid obesity.Methods Twenty-four morbidly obese patients scheduled for laparoscopic gastric banding were divided into three groups.The Group A was given a tidal volume of 12 ml/kg and a respiratory rate of 10 times/min,the Group B,a tidal volume of 20 ml/kg and a respiratory rate of 10 times/min,and the Group C,a tidal volume of 12 ml/kg and a respiratory rate of 20 times/min,respectively.The measurement of arterial blood for pH value,PO2,PCO2,Plat Pressure,Peak Pressure,and AaDO2 was conducted before(T1) and after pneumoperitoneum(T2). Results After pneumoperitoneum,the Group B had significantly higher Plat Pressure(33.2?1.8 cm H2O) and Peak Pressure(36.3?1.6 cm H2O) than the Group A(Plat Pressure: 29.5?3.9 cm H2O,q=3.053,P