2.Clinical efficacy of alprostadil combined with levocarnitine in treatment of chronic renal failure combined with heart failure
Baorong YUAN ; Min LI ; Hui ZHANG
Drug Evaluation Research 2017;40(5):683-686
Objective To discuss the efficacy of alprostadil and levocarnitine in treatment of chronic renal failure combined with heart failure.Methods Totally 80 patients with chronic renal failure complicated with heart failure were selected,and randomly divided into two groups.The control group (39 cases) was given alprostadil.The observation group (41 cases) was given alprostadil and levocarnitine.The efficacy of alprostadil and levocamitine in treatment of chronic renal failure combined with heart failure was evaluated by cardiac fimction indexes,renal function indexes,SF-36 scale score,and adverse reaction during the treatment.Results Before treatment,there was no statistical significance on CO,CI,MVO,and EF between two groups.After treatment,the CO,CI,and MVO were decreased and lower in the observation group (P < 0.05).The EF was increased in the observation group and higher than that of the control group (P < 0.05).The EF had no changes in the control group.Before treatment,there was no statistical significance on CysC,BUN,and SCr between two groups before treatment,without statistical significance.After treatment,CysC,BUN,and SCr were decreased in two groups and lower in the observation group (P < 0.05).Before treatment,there was no statistical significance on SF-36 scores between two groups.After treatment,the physiological function,physical function,and general health were higher than those of the control group (P < 0.05).There was no statistical significance on the rest of the scores.During treatment,there was no statistical significance on adverse reaction between two groups.Conclusion Alprostadil and levocarnitine had a good curative effect on chronic renal failure combined with heart failure.It could improve the heart function by reducing cardiac load,improve the renal function by increasing glomerular filtration rate and improve the quality of life with good safety.It is worthy of clinical application.
3.Expression of immune autoantibodies in children with persistent/chronic immune thrombocytopenia
Shanshan LI ; Hui JIANG ; Min XIA
Chinese Journal of Applied Clinical Pediatrics 2015;30(7):517-520
Objective To investigate the expression and clinical significance of platelet autoantibodies in children with persistent/chronic immune thrombocytopenia (pITP/cITP).Methods Total of 34 children diagnosed with pITP/cITP(14 cases and 20 cases,respectively)in the Department of Hematology and Oncology,Shanghai Children's Hospital from December 2013 to August 2014 were enrolled as the study group,including 20 male and 14 female,the median age of 5 years old.The study also included 20 healthy children (the healthy control group) matched with gender and age,and 24 cases of newly diagnosed ITP (newly diagnosed ITP group) serving as the control groups.Platelet-associated immunoglobulin (PAIg) and platelet-specific autoantibodies on surface of platelets were mea-sured by flow cytometry or flow cytometric bead.Results Significant elevation of PAIgA,PAIgM,PAIgD and specific autoantibodies against glucoprotein(GP) Ⅲa,and GP Ⅱb were demonstrated in children with cITP,as well as specific autoantibodies against GP Ⅰ b,GP Ⅲ a,GP Ⅱ b,and granule membrane protein 140 (GMP140) in children with pITP,compared with the healthy control group(P < 0.05);the levels of GPⅨ,GP Ⅲ a,GMP140 in cITP group and GP Ⅱ b in pITP showed significant declination,compared with the newly diagnosed ITP group(P < 0.05);between piTP group and cITP group,autoantibodies GPⅨ,GP Ⅰ b,GP Ⅱ b,and GMP140 in the latter were much lower(P < 0.05).Significant negative relation between PAIgM and platelet count was found in cITP group (P < 0.05).Receiver operating characte-ristic (ROC) curve analysis showed that the area under ROC curve (AUC) of GP Ⅲ a autoantibodies was larger than that of other platelet-autoantibodies in pITP/ciTP diagnosis.Conclusions Platelet autoantibodies play a significant role in pITP/ciTP,especially platelet-specific autoantibodies,which show a declining tendency in the course and may be the main mechanism.The detection of GPⅢa specific autoantibody is more advantageous against other autoantibodies in the diagnosis of piTP/ciTP.
6.The research progress of volume-sensitive Cl- channel in tumor
Xianjun MIN ; Jun WANG ; Hui LI
Cancer Research and Clinic 2010;22(11):787-789
Cell swelling activates or upregulates a number of anion channels. Of the volume-activated or-regulated anion channels, the volume-sensitive outwardly rectifying anion channel (VSOR) is most prominently activated and ubiquitously expressed. Volume regulated chloride channels play significant roles in a variety of physiological processes including volume regulation, proliferation, differentiation, migration,apoptosis and resistance of tumor cells. Molecular identification and activation mechanisms of VSOR are poorly understood. Many signaling molecules have been shown to regulate VSOR activity in research, playing permissive or modulatory roles. Therefore, VSOR may be a new anticancer target by identifying its signaling molecules and activation mechanisms.
8.Electrogastrographic parameters from 40 healthy subjects 6 to 14 years of age.
Yan YANG ; Hui-min YAN ; Ming LI
Chinese Journal of Pediatrics 2005;43(9):697-698
Adolescent
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Child
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Electromyography
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Female
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Humans
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Male
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Stomach
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physiology
9.Effect of Vibroacoustic Therapy on Behavioral Problem for Children with Cerebral Injury
Hui CHENG ; Zeping LI ; Min SHEN
Chinese Journal of Rehabilitation Theory and Practice 2012;18(7):673-675
Objective To investigate the effect of vibroacoustic therapy on the behavioral problem for children with cerebral injury. ethods 20 cerebral injury children (aged 6~8 years) with behavioral problem judged with Conners Parent Symptom Questionnaire (PSQ) ccepted vibroaacoustic therapy. Their PSQ scores were reviewed before and after treatment. Results Comparing with the norm, the scores f conduct problems, learning problems, anxiety and impulsivity-hyperactivity were higher in cerebral injured boys, while the scores of hysical symptoms and anxiety were higher in girls. The scores of learning problem, anxiety, impulsivity-hyperactivity and hyperactivity index educed after the vibroacoustic therapy (P<0.05). Conclusion Vibroacoustic therapy can alleviate the behavioral problems of children ith cerebral injury.