Unilateral neglect is one of the common advanced neurological deficits of stroke. This article highlights the post-stroke definition of unilateral neglect, incidence, sites of lesion resulting in neglect, possible mechanisms and clinical manifestation. It overviews the typing and complications of unilateral neglect, and points out that the significance on the assessment and treatment of unilateral neglect.

Unilateral neglect is a common and advanced nervous disorder of stroke, well-recognized predictor of poor neural functional outcome following stroke. There are several rehabilitation Methods including sensation input, visual scanning training, vestibular stimulation, head and trunk rotation, suggestive therapy, environmental adaptation and activities of daily living training, and some new therapies including prism adaptation, constraint-induced movement therapy, eye patching and transcranial magnetic stimulation developed in the past few years, which to some extent are effective on the treatment of neglect.

Abstract: Objective　To investigate the impacts of vaccination with inactivated SARS-COV-2 vaccine on the clinical manifestations and serological responses of COVID-19 patients infected by Delta and Alpha variants. Methods　Clinical and experimental data of 341 confirmed SARS-COV-2 patients were collected from The Eighth Affiliated Hospital of Guangzhou Medical University May 1- September 30, 2021. The subjects were divided into Delta and Alpha variant group according to virus variants, and were divided into vaccinated group and unvaccinated group according to whether they had received inactivated COVID-19 vaccine or not. The clinical manifestations and serological responses of patients with Delta and Alpha variant, and vaccinated and unvaccinated patients with Delta and Alpha variants were compared. Results　Totally 253 patients were infected with Delta variant (103 vaccinated and 150 unvaccinated patients), and 88 patients were infected with Alpha variant (21 vaccinated and 67 unvaccinated patients). The proportion of asymptomatic infection in Delta variants group was significantly lower than that in Alpha variants group (P<0.01). Delta variant group of vaccination rates and vaccine breakthrough infection rate was 40.7% (103/253) and 22.9% (58/253), were higher than Alpha variant group was 23.9% (21/88) and 8.0% (7/88), difference was statistically significant (χ2= 8.009, 9.484, P<0.01). The proportion of cough and fever in Delta variant group was higher than that in Alpha variant group (both P<0.01), the peak viral load was higher than that of Alpha variant group (P<0.01), the virus duration was longer than that of Alpha variant group (P<0.01), the levels of SAA, CRP and IFN were higher than those of Alpha variant group (all P<0.05), CD4+T cell count was lower than that of Alpha variant group (P<0.05), IgG and IgM levels were lower than those of Alpha variant group (both P<0.01). The proportion of moderate COVID-19 in the vaccinated group was lower than that in the unvaccinated group (P<0.01). In these two variants, the peak viral load of vaccinated group was lower than that of the unvaccinated group (both P<0.01), the duration of virus was shorter than that of unvaccinated group (both P<0.01). The levels of SAA, CRP and IL-6 in the vaccinated group were lower than those in the unvaccinated group (all P<0.05), CD4+T cell level was higher than that of unvaccinated group (both P<0.05), IgG and IgM level were higher than those in unvaccinated group (both P<0.05). Conclusions　Delta variant can lead to higher viral load and more severe disease course, which is associated with vaccine breakthrough infection. Inactivated vaccines for COVID-19 can reduce severe illness and death by reducing viral load, disease duration and inflammatory response through humoral and cellular immune mechanisms.

To explore the effects of Yixin Jiedu Formula (YXJDF), a compound Chinese herbal medicine, on hemodynamic and B-type natriuretic (BNP) in a rat model of heart failure with qi deficiency and blood stasis syndrome. Moreover, its therapeutic effects in improving the symptoms were also studied.

To study the changes of plasma metabolites of mini-swines with qi deficiency and blood stasis syndrome due to chronic myocardial ischemia and to explore the relationship between plasma metabonomics and qi deficiency and blood stasis syndrome.

Names of epilepsy may refl ect misconception and contribute to stigma in epilepsy. Epilepsy in Chinese (dian xian, madness; yang dian feng, goat madness) is associated with insanity and animals. Because of the infl uence of Traditional Chinese Medicine, the names of epilepsy in certain East and Southeast Asian languages also convey the image of insanity and associated with animals. In the case of Malay who are mainly Muslim, it is also religiously unclean (gila babi, mad pig disease), contributing to stigma of the epilepsy patients. Of the East and South East Asian languages, epilepsy in Chinese, Japanese, Korean, Malay, Lao, Thai, Burmese, and Khmer (Cambodia) has the connotation of madness. The names of epilepsy have been replaced by a neutral terminology in Malay in Malaysia, and recently also for Chinese in Hong Kong, and Korean in South Korea.

OBJECTIVETo study the Chinese medical syndrome characteristics of the miniature pig model of coronary heart disease (CHD) made by chronic myocardial ischemia, and its correlation with heart structure and function.

METHODSChinese miniature pigs were randomly divided into two groups, 18 in the model group and 8 in the sham-operation group. CHD model was established by placing Ameroid narrow ring in the left anterior descending artery of pigs to induce chronic myocardial ischemia. Characteristics of Chinese medical syndrome in the model were evaluated 8-12 weeks after modeling by observing the general condition, tongue color, activity, hemorrheologic figures, electrocardiogram, coronary angiography, etc., as well as the cardiac structure and function detected by echocardiogram.

RESULTSCompared with the sham-operation group, the modeled pigs showed, at end of the 8th week, pink purple tongue; decreased tail wagging frequency (P < 0.05 or P < 0.01); increased plasma and reduction viscosities (P < 0.05); and raised rigidity index (P < 0.01), with the stenosed diameter of coronary artery reaching 99%. Besides, echocardiogram showed decreased thickness of left ventricular end-systolic stage, end-diastolic stage and inter-ventricular septum end-diastolic stage; lowered ejection fraction and fractional shortening rate (P < 0.05 or P < 0.01), and dilated left ventricular end-diastolic diameter and left ventricular end-systolic diameter. The motion of ventricular wall was decreased orderly in levels from the mitral valve to the papillary muscle to the apex of heart.

CONCLUSIONSCHD pig model made by chronic myocardial ischemia showed a Chinese medical qi-deficiency & blood-stasis syndrome. It indicated that a syndrome transition and conversion progress from blood-stasis to qi-deficiency & blood stasis occurred in the model animals at the 4th to 12th week. The created model provided a reliable basis for further studying rules of syndrome transition and conversion between qi deficiency and blood stasis, as well as on the Chinese medical theory of "blood is mother of qi".

Animals ; Coronary Disease ; diagnosis ; Disease Models, Animal ; Male ; Medicine, Chinese Traditional ; Myocardial Ischemia ; diagnosis ; Swine ; Swine, Miniature

Objective To analyze the characteristics of clinical manifestations, risk factors, therapies and acute outcomes in patients with cerebral venous sinus thrombosis complicated by cerebral hemorrhage. Methods Seventy-five patients with cerebral venous sinus thrombosis were included in the study. According to the radiological findings on the brain image, patients were divided into two subgroups:cerebral hemorrhage group and non-hemorrhage group. The demo?graphic data, potential risk factors, clinical manifestations, radiological features, therapeutic strategies and acute out?comes were compared between two subgroups, and high risk factors were also analyzed. Results There were seventy-five patients with cerebral venous sinus thrombosis in the present study. Twenty-eight patients of them (37.2%) had cerebral hemorrhage whereas the remaining forty-seven patients (62.7%) did not have cerebral hemorrhage. Pregnancy/puerperi?um were significantly higher in patients with cerebral hemorrhage (with vs without;28.6%vs. 6.4%, P=0.015), while in?fection was markedly higher in patients without cerebral hemorrhage (with vs without;7.1% vs. 29.8%, P=0.021). Head?ache (92.9% vs. 70.2%, P=0.021), unconsciousness (25.0% vs. 6.4%,P=0.034), seizures (53.6% vs. 19.1%, P=0.002) and motor deficits (35.7% vs. 12.8%, P=0.019) were more common in patients with cerebral hemorrhage. Moreover, mul?tiple sinus involvement (1.4% vs. 44.7%, P=0.024) was significantly higher and the acute outcomes(mRS≥3: 46.4%vs.17.0%, P=0.006)were poorer in patients with cerebral hemorrhage. Binary Logistic analysis showed that pregnancy/pu?erperium (P=0.004) and multiple sinus involvement were positively, whereas infection was negatively correlated with cere?bral venous sinus thrombosis and hemorrhage ( P=0.007;P=0.03). Conclusions Pregnancy/puerperium, headache, uncon?sciousness, seizures, motor deficits and multiple sinus involvement are more frequently in patients with cerebral venous sinus thrombosis and hemorrhage, and the acute outcomes are poorer in patients with cerebral venous sinus thrombosis complicated by cerebral hemorrhage.

OBJECTIVETo inquire the characteristic proteins in chronic myocardial ischemia by testing twodimensional electrophoresis (2-DE) map to explore the possible inherent pathological mechanism and the therapeutic intervention of qi deficiency and blood stasis syndrome.

METHODSAmeroid constrictor ring was placed on the first interval of left anterior descending coronary artery to prepare chronic myocardial ischemia model on Chinese miniature swine. Animals were randomly divided into sham group and model group with 10 animals in each group, respectively. The dynamic symptoms observation of the four diagnostic information was collected from 0 to 12 weeks. Echocardiography was employed to evaluate cardiac function and the degree of myocardial ischemia, 2-DE and matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF-MS) were used to carry out proteomics research on animals. Enzyme-linked immunosorbent assay was applied to identify the relevant differential proteins on chronic myocardial ischemia with qi deficiency and blood stasis syndrome.

RESULTSThe preliminary study found that at the 12th week, chronic myocardial ischemia with qi deficiency and blood stasis syndrome model was established stably. Compared with the sham group, there were 8 different proteins down-regulated, 22 proteins up-regulated significantly. After validated by MALDITOF-MS/MS, 11 protein spots were identified. Distinct proteins were mainly associated with energy metabolism and myocardial structural injury, including isocitrate dehydrogenase 3 (NAD+) alpha, NADH dehydrogenase (NAD) Fe-S protein 1, chain A (crystal structure of aldose reductase by binding domain reveals a new Nadph), heat shock protein 27 (HSP27), oxidoreductase (NAD-binding protein), antioxidant protein isoform, cardiac troponin T (cTnT), myosin (myosin light polypeptide), cardiac alpha tropomyosin, apolipoprotein A-I and albumin.

CONCLUSIONDown-regulated energy metabolism disorder mediated by NADH respiratory chain and myocardial injury may be the pathogenesis of myocardial ischemia with qi deficiency and blood stasis syndrome. These proteins may be the potential diagnostic marker(s) for qi deficiency and blood stasis syndrome, finally provided new clues for new therapeutic drug target of Chinese medicine.

Animals ; Blood Coagulation Disorders ; complications ; metabolism ; Electrophoresis, Gel, Two-Dimensional ; Energy Metabolism ; physiology ; Metabolic Diseases ; etiology ; metabolism ; Myocardial Ischemia ; complications ; metabolism ; Myocardial Reperfusion Injury ; etiology ; metabolism ; Proteomics ; methods ; Qi ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Swine ; Swine, Miniature ; Syndrome

China ; Epilepsy ; pathology ; Humans ; Prognosis