Objective To investigate the relationship among microvessel density (MVD),the expressions of Neu gene and estrogen receptor(ER) and prognosis in early breast cancer.Methods MVD,the expression of Neu gene and ER was examined in radical operation samples from 94 cases of breast cancer without lymphatic metastatis.Results The MVD, expression of Neu gene and ER in 94 cases of early breast cancer were 35 4?9 8,44 percent(41/94),61 percent (58/94)respectively;Three years after operation,16 cases had relapse in 94 cases of early breast cancer. The MVD of the relapse cases were 42 5?10 6, which was higher than that of non-relapse,whose MVD was 31 4?8 7,there was obvious difference(P0 05).Conclusions Whether there is a lymphoglandula metastasis is an important factor in evaluating prognosis of breast cancer.After radical operation there still are partly replase case in the breast cancer without lymphoglandula metastasis.MVD and Neu gene expression are important factors to estimate prognosis of the early breast cancer.Breast cancer which has higher MVD and Neu gene expression has worse prognosis than that of lower MVD and negative Neu gene expression. [