2.Evaluation of the preventive effects of nosocomial post abortion care on repeated pregnancy in unmarried female people
Clinical Medicine of China 2015;31(1):9-12
Objective To investigate the preventive effect of post abortion care(PAC) on unsafe sexual behaviors and deficiency in the knowledge of unmarried females,especially the youth in order to prevent repeated.unintended pregnancies as well as to promote the unmarried female's reproductive health.Methods During the period from Jan.2012 to Jun.2013,171 unmarried young women (< 24 years old) were enrolled in the study who were underwent free willed induced abortion due to unwanted pregnancy in Maternal and Child Health-Care Hospital of Huangpu District of Shanghai.Their reproductive health related knowledge,attitude and behavior were investigated by questionnaires.Based on the information above,they were provided with a series of post abortion services and improvement of reproductive health cognition and prevention effect of repeat pregnancy were evaluated after the intervention.Results After the nosocomial PAC intervention,the research objects are improved in the contraceptive knowledge and contraceptive behavior largely than before.The awareness rate on the female fertile time was increased from 53.8% (92/171) to 80.6% (137/170).The common contraceptive awareness rate increased from 49.1% (84/171) to 91.8% (156/170).The difference was statistically significant (x2 =27.30,x2 =75.69,P < 0.05).After 1 year follow-up,the PAC intervention make in contraceptive behavior change.The contraception rate increased from 8.2% (14/171) to 65.3% (111/170).The contraceptive failure rate was reduced from 35.7% (61/171) to 4.7% (8/170) (x2 =165.24,36.12,P < 0.05).There was not complications occurrence.Conclusion PAC can improve the contraception rate and reduce the unmarried female youth repeated abortion rate effectively.
4.Analysis of national natural science foundation of China grants in financial years of 2010-2013 in field of laboratory medicine and future perspectives
Lixiang XUE ; Kun LYU ; Zhangcai YAN
Chinese Journal of Laboratory Medicine 2014;37(3):236-238
The grants received and funded from 2010 to 2013 in laboratory medicine field were analyzed.The current research team in the laboratory medicine is analyzed as well.The instructions of the grants related to different kinds of biomarkers in diagnosis and prediction of diseases were elucidated.The perspectives of basic research in laboratory medicine was raised in the end.
5.Elementary inquiry into the mechanism of annexation of bradykinin and papaverine on BTB opening
Wenfang QIAO ; Kun LIU ; Yixue XUE
Chinese Pharmacological Bulletin 2003;0(11):-
Aim To investigate whether the annexation of bradykinin and papaverine had some synergetic effects on the opening of blood-tumor barrier,and find out the action of cytokine in this mechanism.Methods 160 female rats were divided into 8 groups:sham operated group;model group,PA group,BK group,PA+BK group,1/2PA+BK group,1/2BK+PA group and 1/2PA+1/2BK group.20 rats were needed in each group.The C6 brain tumor model was built.The drug was pumped into rat's brain via the carotid artery.The opening of the tight junction was detected by electron microscop.And the permeability of the blood-tumor barrier was tested by Evans blue.The expression of IL-1? was tested by Western blot and the expression of IL-1? on/around the capillary in the brain of the cerebral glioma rats was tested by SABC immunochemistry.Results In contrast to sham operated group/model group,the expression of IL-1? in PA group,BK group and PA+BK group increased obviously(P
6.Validation of Microbial Limit Test Method of 11 Kinds of Oral Chinese Patent Medicines
Hong YAN ; Kun XUE ; Yuedan ZHANG
China Pharmacy 2001;0(11):-
OBJECTIVE: To study the antimicrobial effect of 11 kinds of oral Chinese patent medicines and to establish microbial limit test method for them. METHODS: Common method and culture medium dilution method and sticked filter membrane method were used to do the recovery test in order to validate the scientificity and feasibility of established method. RESULTS: Danqi piantan capsule showed strong inhibition effect on Staphylococcus aureus and Bacillus subtilis. Xinshuning tablet, Fuzheng mixture, Shenkangning mixture, Qingshen xiaodu oral liquid had antimicrobial effect on Staphylococcus aureus to some extent. Banlangen granule had antimicrobial effect on Bacillus subtilis. The effect can be eliminated by culture medium dilution method. CONCLUSION: The common method can be used for the microbial limit test of Jiaoou capsule, Zhike ningsou capsule, Rongdanshi granule, Sanjie mingmu capsule, Jiangzhi ruanmai tablet. Dilution method can be used for the microbial limit test of Xinshuning tablet, Fuzheng mixture, Shenkangning mixture, Qingshen xiaodu oral liquid, Banlangen granule, Danqi piantan capsule. The common method is suitable for all kinds of specified microorganisms.
7.A Clinical Study of Gongmo Kang Capsule in Treating Metrorrhagia Caused by Drug-Induced Abortion
Qiong ZHANG ; Saiqin XUE ; Kun JIANG
Traditional Chinese Drug Research & Clinical Pharmacology 2000;0(05):-
Objective: To assess the therapeutic effect and safety of Gongmo Kang capsule (GKC) in treating metrorrhagia (with blood stasis syndrome) caused by drug - induced abortion. Methods: A randomized double - blind controlled design was adopted. One hundred and five patients were treated with GKC, and other 104 patients in the control group with Gongxue Ning capsule (GNC). Results: In GKC group, the remarkably effective rate was 73. 33%, the total effective rate was 85. 70% ; the remarkably effective rate for improving syndromes was 80.00% and the total effective rate was 88.57% ; the mean bleeding period was (4.46 ? 1.71) days. GKC appeared to be more effective than GNC (P
9.Effect of butylphthalide on the expression of GFAP and VEGF in the hippocampus of rats with (Alzheimer's) disease
Deren HOU ; Li XUE ; Kun CHEN ; Yi TIAN ; Shun WAN
Journal of Central South University(Medical Sciences) 2010;35(2):111-115
Objective To determine the expression of glial fibrillary acidic protein(GFAP) and vascular endothelial growth factor(VEGF) in the hippocampus of rats with Alzheimer's disease(AD), and to determine the effect of butylphthalide on them and its significance. Methods Sixty male adult rats were randomly divided into a model group, a Butylphthalide group, and a control group. AD models were established by injecting β-amyloid protein 1-42 into the hippocampus of rats. Sixty days later,the rats were sacrificed and both sides of the hippocampus were sectioned for immunohistochemistry. Results Positive cells of GFAP in the hippocampus of the model group increased and the expression of VEGF decreased statistically, compared with the control group(P<0.01). The positive cells of GFAP in the hippocampus of the butylphthalide group decreased and the expression of VEGF increased significantly, compared with the model group(P<0.05). Conclusion Butylphthalide may protect the neuron-vascular unit of the hippocampus of Alzheimer model rats by inhibiting the expression of GFAP and increasing the expression of VEGF.
10.Study on visualization of congenital heart disease by three-dimensional echocardiographic virtual endoscopy
Haihong XUE ; Kun SUN ; Jianguo YU ; Binjin CHEN ; Weiqi WANG
Chinese Journal of Ultrasonography 2010;19(8):645-648
Objective To research the visualization of congenital heart disease by three-dimensional echocardiographic(3DE) virtual endoscopy(VE) system. Methods Datasets.from 10 healthy children and 22 patients with congenital heart disease were collected (10 patients with atrial septal defects, 6 patients with ventricular septal defects and 6 patients with tetralogy of Fallot). 3DE heart models were reconstructed by virtual reality computing techniques and visualization in scientific computing techniques. The VE system was programmed under the C++ 6.0 language condition,the visualization toolkit (VTK) platform was employed to carry out the graphics and visualization utilities. The virtual eye can move along the navigation paths in the heart by manual camera movements. Results The VE can provide special information in aspects of intracardiac anatomy, The visible heart models show precisely complex anatomy structure and spatial relationships. 3DE intracardiac endoscopic imaging can thus be visualized and navigated successfully by the VE system. Conclusions 3DE VE is a new system for the visualization of congenital heart disease.