Hedgehog(HH),a vital endodermal signal,plays a critical role in the embryonic development of the GI system.During mammalian embryonic development,deficiency of HH signaling leads to gastrointestinal malformations.Nevertheless,normal presence of HH family is also found in the adult gut,and HH signaling now may be important for homeostasis of the gut in such a case.However,many researches revealed that the HH signal's involved in gastrointestinal carcinogenesis and its role is altered in various tumors due to various mechanisms.This review focused on the progress of HH signal pathway in gastrointestinal tumors.

Adult ; Female ; Hair Follicle ; pathology ; Humans ; Pilomatrixoma ; Skin Neoplasms

Gait recognition is a new technology in biometric recognition and medical treatment which has advantages such as long-distance and non-invasiveness. Depending on the differences between different people's walking pos tures, we can recognize individuals by characteristics extracted from the images of walking movement. A complete gait recognition process usually includes gait sequence acquisition, gait detection, feature extracting and recognition. In this paper, the commonly used methods of these four processes are introduced, and feature extraction methods are classified from different multi-angle views. And then the new algorithm of multi-view emerged in recent years is highlighted. In addition, this paper summarizes the existing difficulties of gait recognition, and looks into the future development trends of it.
Algorithms ; Biometry ; Gait ; Humans ; Image Interpretation, Computer-Assisted ; Walking

Objective To research the association of IR and β-cell function with MS in T2DM.Methods 116 T2DM subjects were divided into two groups:MS(n=60)and T2DM(n=56),and FIns,FPG,BP and other items were measured.Results HOMA-IR was significantly higher in MS than in T2DM and control group(P<0.05).HOMA-β was significantly lower in MS than in T2DM and control group(P<0.05).And FPG,waist circumference(WC)in MS group were positively correlated with the IR level(P<0.05).Conclusions The HOMA-IR was highest in T2DM with MS,and HOMA-β was lowest in T2DM with MS

Objective:To develop an HPLC-DAD method for the simultaneous determination of seven alkaloid constitutents, so-phoranholN-oxide, oxymatrine, sophoridine, oxysophocarpine, sophoranol, matrine and sophocarpine in Sophora flavescens Ait. Meth-ods:The chromatographic separation was performed on an Agilent Zorbax C18 column (150 mm × 4. 6 mm, 5μm) with 10 mmol·L-1 NH4Ac(0.1% ammonia, pH=9.0)(A)-acetonitrile-methanol(1 ∶22) containing 20 mmol·L-1NH4Ac(B) as the mobile phase with gradient elution at the flow rate of 1 ml·min-1 . The detection wavelength was set at 220 nm,and the column temperature was maintained at 30 ℃. Results: SophoranholN-oxide, oxymatrine, sophoridine, oxysoph-ocarpine, sophoranol, matrine and sopho-carpine was linear within the range of 0.093-1.860 μg(r =0.999 6) , 0.530-10.600 μg (r =0.999 7), 0.062-1.240 μg (r =0. 999 8), 0. 281-5. 620 μg (r=0. 999 9), 0. 026-0. 520 μg (r=0. 999 8) ,0. 036-0. 720 μg (r=0. 999 7) and 0. 032-0. 640 μg (r=0. 999 6), respectively. The average recovery was 97. 5%, 98. 2%, 99. 0%, 99. 4%, 99. 2%, 98. 2% and 98. 7%, and RSD was 1. 18%, 0. 92%, 1. 43%, 1. 04%, 0. 81%, 0. 43% and 0. 88%(n =6), respectively. Conclusion:The method is convenient, accurate and reproducible in the quality control of multicomponents in Sophora flavescens Ait.

Cancer pain can seriously disturb patients′quality of life.Intractable cancer pain not ame-nable to standard analgesics is a horrifying truth in parts of the patients.Interventional pain management tech-niques can be an effective alternative for those patients.Based on the evidence of evidence-based medicine, celiac plexus block or splanchnic nerve block are recommended for the management of upper abdominal cancer pain,pelvic cancer pain can be managed with superior hypogastric plexus block,and back pain due to vertebral compression fractures with tumor invasion can be managed with percutaneous vertebroplasty or kyphoplasty. Intercostal nerve block for chest wall cancer pain,ganglion impar block and saddle block for perineal pain due to pelvic tumors should be used only in the context of an experimental study or in cases of compassionate use with no other available forms of effective pain relief.

Objective To establish a animal model for diffusion mesangioproliferation complicating focal segmentally glomerulosclerosis.Methods The models were established in the seventieth day by repetitive injection of 4mg/kg and 3mg/kg adriamycin to the SD rats in the 7th and 30th day after removal of their right kidneys.Results Serious edema, profuse albuminuria, hypoalbuminemia, hyperlipemia and renal failure were presented. Simultaneously, diffuse medium- or serious-grade proliferation of mesangial matrix, slight-grade proliferation of mesangial cells, segmental sclerosis of 22% of glomeruli, and overexpression of PDGF-B and bFGF in glomeruli were showed by pathologic examination, computerized image analysis and immunohistochemistry staining.Conclusions The models established in the transition stage from mesangioproliferation to glomerulosclerosis are helpful to study mechanisms and take measures for prevention and cure of chronic glomerulonephritis.

No abstract available.
Abscess* ; Reoperation*

Objective To discuss the effective measures for skin allergy caused by hyaline mem-brane after deep venous catheterization. Methods Patients (102 eases) were divided into the control group(50 cases) and the test group(52 cases).3M hyaline membrane was patched on the skin directly to fix the catheter after successful puncture in the control group.While in the test group 3M hyaline membrane was patched on the skin after 3M painless protective membrane was sprayed on the skin. Results The incidence of skin allergy in the test group was lower than that of the control group. Conclusions Spray of 3M painless protective membrane before usage of hyaline membrane to fix the catheter could prevent the incidence of skin allergy after deep venous catheterization.

Objective:To observe the thrombolytic effect of Naoxuebao in vitro and in vivo.Methods:The changes of thrombus in the carotid arterial,plasma fibrinogen (FIB),thrombin time (TT) and the diameter of blood clot were observed using Naoxuebao (three dose groups) after thrombosis.Results:With Naoxuebao,the time of blood clot was longer,the diameter of blood clot was shortened;carotid arterial thrombosis was dissolved.The contents of FIB decreased,TT was longer,and FIB and TT had negative correlation;whereas,PLG had no obious change.Conclusion:Naoxuebao had thrombolytic effect,but the effect had no relation with plasmin activating.