No abstract available.
Child* ; Humans ; Mass Screening* ; Seoul*

This article describes the activity of the "Medical termonology practical committee (MTPC) of Korean Medical Association (KMA). In 2001, MTPC of KMA published the 4th edition of "English-Korean, Korean-English Medical terminology" which contains about 5,000 medical terms. The MTPC will continue reviewing the vocabularies. Obsolete terms will be discarded, new terms will be added, and the remainder will be revised by through-going revision of vocabulary. Our aim is to reflect the current usage of medical terms in the form of easily understandable Korean terms.
Vocabulary

With a high incidence, cancer pain is an unresolved clinical problem right now. Many randomized controlled studies have shown that intrathecal infusion of analgesic drugs is an effective way to relieve pain. Intrathecal drug infusion system provides cli-nicians with exact individualized treatment approach in the effective analgesia, but with minimum side effects. Patients who received in-trathecal analgesic therapy in the early stage would get more benefit. Before implanting intrathecal drug delivery devices, it is needed to test analgesic effect firstly, and the proper implementation of the test period is extremely important. This effectively maintaining time decides whether the patients need intrathecal analgesia system. However, there are many factors that may affect its application in clin-ic. This article focuses on the treatment principle, patient selection, testing, technical problems and complications when applying intra-thecal drug delivery devices.

Objective:To explore the correlation between lipid metabolism and coronary atherosclerosis in advanced aged patients with coronary heart disease (CHD) .Methods:A total of 95 advanced aged patients ,who were suspec-ted CHD and received coronary angiography (CAG) in our hospital from Dec 2010 to Dec 2013 ,were selected .Ac-cording to CAG results ,the 95 patients were divided into CHD group (n=43) and non-CHD group (n=52) .Their clinical data were retrospectively analyzed ,and the correlations between blood lipids and coronary atherosclerosis were analyzed .Results:Compared with non-CHD group , the ratio of low density lipoprotein cholesterol to high density lipoprotein cholesterol (LDL-C/HDL-C) [ (2.01 ± 0.65) vs .(2.38 ± 0.92) , P=0.024] significantly rose in CHD group .In CHD group ,number of diseased coronary vessel was positively correlated with triglyceride (TG) level ,LDL-C/HDL-C ,TG/HDL-C and atherogenic index of plasma (AIP) , r=0.183~0.256 (P<0.05 all) ,and inversely correlated with HDL-C level (r= -0.243 ,P<0.05);coronary stenosis degree was positively correlated with LDL-C/HDL-C ,TG/HDL-C and AIP (r=0.225~0.331 ,P<0.05) ,and inversely correlated with HDL-C level (r= -0.261 ,P<0.05) .In CHD group ,total Gensini score was positively correlated with blood lipid indexes (r=0.068~0.201 ,P<0.05 or <0.01) and inversely correlated with HDL-C level (r= -0.138 ,P<0.01) .Con-clusion:Elevated plasma HDL-C level can delay progression of coronary heart disease in advanced aged patients with coronary heart disease .LDL-C/HDL-C and AIP are indexes evaluating severity and risk of coronary atherosclerosis in patients with coronary heart disease .

Objective To investigate the clinical efficacy and safety of the pegylated interferon alpha-2a (PEG-IFN-a-2a)in treatment of chronic hepatitis C.Methods 170 cases of patients with chronic hepatitis C were included in the study,by using digital table method they were randomly divided into two groups,the observation group of 85 cases were treated with PEG-IFN-alpha-2a therapy,and 85 cases in the control group using ordinary interferon alpha-2b therapy.Curative effect and safety of two groups of patients were compared.Results The obser-vation group treated for 12 weeks,24 weeks and 24 weeks of alanine aminotransferase (ALT)and improvement rate were respectively 70.59%,80%,92.94%,which were higher than that of the control group (52.94%,62.35% and 70.58%)(χ2 =5.42,6.71,4.83,all P<0.05).The observation group for 12 weeks,24 weeks and 24 weeks of HCV-RNA negative rate were 64.71%,75.29%and 91.76%,obviously were higher than the control group of50.59%, 61.18% and 70.59% (χ2 =4.28,7.68,6.31,all P<0.05).Adverse reaction rates were not statistically signifi-cant.Conclusion The pegylated interferon alpha-2a (PEG-IFN-a-2a)in treatment of chronic hepatitis C has a significant curative effect of PEG-IFN-alpha-2a therapy in chronic hepatitis C,which is better than the ordinary interferon alpha-2b,and is worthy of extensive promotion and application.

Objective To reduce the hypokalemia caused by inner environment imbalance effectively in order to lower the death rate and improve the prognosis for patients with severe cranial injury.Methods Seventy-five patients with severe cranial injury who had hypokalemia were studied retrospoctively from October 10th,2003 to July 30th,2006.Results The waves of electrocardiogram and changes of illness condition was closely observed,the volume:of intake and output and kalium outcome was accurately recorded.Kalium was supplemented as early as possible.the amount was adjusted by the use of dehydratins agents and biochemical kalium.Only timely and effective monitoring and treatment could complications be reduced or prevented.Conclusions Severe cranial injury is one of the most severe trauma,timely monitoring and nursing measures are key point for rectification of hypokalemia for patients with severe cranial injury.

microRNA(miRNA) ,a class of small noncoding RNAs,negatively regulates gene expression at post-transcriptional level, and is involved in many fundamental biological processes, including development,apoptosis and cell proliferation, p53 is a transcription factor that plays a critical role in the control of cell cycle and apoptosis. Aberrant expression of either miRNA or p53 intimately links to tumorigenesis. This article reviews recent advances in the study of inter-relatioship between miRNA and p53 in tumorigenesis.

Acupuncture Therapy ; Adult ; Female ; Humans ; Male ; Temporomandibular Joint ; physiopathology ; Temporomandibular Joint Dysfunction Syndrome ; physiopathology ; therapy

OBJECTIVE:To establish early warning mechanisms of antibiotics drug resistance,and to provide reference for ra-tional drug use in the clinic. METHODS:The consumption amount of top 3 to 10 drugs in the list of consumption sum and amount in outpatient prescription and inpatient medical orders of our hospital during 2014 was analyzed statistically,including antibiotics, anti-tumor drugs,drugs for cardiovascular system,drugs for digestive system,biologicals. Top 5 Gram-positive bacterial and Gram-negative bacterial which induced infection in our hospital in Nov. 2014 was analyzed statistically in terms of resistant rate. RE-SULTS:Total consumption sum of drugs was 16 038.28 ten thousand yuan in our hospital in 2014,accounting for 27.95%;antibi-otics drugs accounted for 9.55%(1 531.44 ten thousand yuan) of total consumption sum,drugs for cardiovascular system 3.30%(529.60 ten thousand yuan),drugs for digestive system 8.32%(1 333.68 ten thousand yuan),anti-tumor drugs 2.93%(469.27 ten thousand yuan),and biologicals 3.50%(561.22 ten thousand yuan). 1 575 bacterial samples were detected in Nov. 2014,and bacte-rial were detected in 358 samples with positive rate of 22.73%. 136 Gram-positive bacterial were detected,and top 5 were Staphylo-coccus epidermidis, Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium and Streptococcus agalactiae. 222 Gram-negative bacterial were detected,and top 5 were Escherichia coli,Klebsiella pneumoniae,Acinetobacter baumannii,Hae-mophilus influenzae and Enterobacter cloacae. CONCLUSIONS:Five categories of drugs used in our hospital is rational compara-tively,and the proprotion of antibiotics in total consumption sum is much lower than other hospitals;control and standardization of antibiotics use has made some achievements.

OBJECTIVE:To establish a method for content determination of the principal agent in bumetanide tablets by HPLC-fluoremetry.METHODS:HPLC-fluoremetry was carried out using a Kromasil C 18 column and a mobile phase con?sisting of acetonitrile-water(50∶50),the fluorescence detector of228nm for excitation and418nm for emission was used,the internal standard was dixiben,the flow rate was0.6ml/min,the sample size was20?l,the column temperature was the same as room temperature.RESULTS:The concentration of bumetanide was linear in the range of16.75～335.00?g/ml(r=0.9997),the average recovery was99.26%(RSD=0.49%,n=3).CONCLUSION:The present method is convenient and reliable,whi_ ch can be used for content determination of the principal agent in bumetanide tablets.