Patients frequently visit dentists with main intention of pain relief. Among various causes of pain, the temporomandibular disorder representing a group is one of them. Every dental practitioner should be aware of these disorders and the mode of treating them. Pharmacology usually represents the first stage of management or as an additional treatment for these disorders. Commonly used pharmacotherapeutic medicines include analgesics, corticosteroids, muscle relaxants, antidepressants and sedative-hypnotics. Analgesics such as naproxen, diclofenac, ibuprofen and corticosteroids such as methylprednisolone, triamcinolone acetonide are beneficial in relieving pain of acute and chronic temporomandibular disorders associated with inflammation. Muscle relaxants such as cyclobenzaprine and chlorzoxazone can be given for pain of temporomandibular disorders associated with muscular tensions and spasms. Sedative- hypnotics are helpful to patients who have muscular tension together with poor sleep patterns. Antidepressants like amitriptyline are effective in chronic myofascial pain syndrome and in patients with coexistent depression and tension headaches. Benzodiazepines such as clonazepam and diazepam are helpful in chronic myogenous jaw pain. The article attempts to review the pharmacological management of temporomandibular disorders in a concise manner so as to be helpful for medical and dental practitioners.

Oral myiasis is a rare disease caused by larvae of certain dipteran flies. A case of oral myiasis caused by chrysomya bezziana, in the maxillary anterior region in a 20 year old mentally challenged female patient is reported. Manual removal of the larvae by topical application of turpentine oil, surgical debridement of the oral wound, followed by oral therapy with broad spectrum antibiotics were used to manage the patient.

Objective: To investigate oxidative stress, hemoglobin percentage and erythrocyte osmotic fragility in various aging groups. Methods: A total of 200 healthy volunteers of both genders between age group 20-65 years were selected by random method. Determination of hemoglobin percentage was done employing modified cyanide method of Dacie and Lewis. The erythrocyte lysis was observed in hypotonic solution of buffered saline at varying concentrations and optical density was measured at 540 nm. The extent of lipid peroxidation in form of malondialdehyde was measured by thiobarbituric acid method. Results: The study found a significant decrease in hemoglobin percentage, increase in erythrocyte osmotic fragility and increased lipid peroxidation in form of malondialdehyde with increasing age. Conclusions: Supplementation of antioxidants may prevent the oxidative injury in elderly group of subjects.

Objective: The present study is an attempt to explore the anti-inflammatory activity of n-Hexane extract (HS), Ethyl acetate extract (EAS) and Residual ethanolic extract (RES) of fruits of Sida tiagii Bhandari by using carrageenan and egg-albumin induced paw edema, xylene induced ear edema and cotton wool granuloma animal models. Methods: The biochemical markers like or lysosomal enzymes viz. serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT) and alkaline phosphatase (ALP) were also found out in blood serum. Results:There was decrease in edema volume in EAS and RES administered animals in carrageenan and egg-albumin induced edema models. The percentage inhibition of inflammation in EAS (34.15%) and RES (39.66%) was found comparable with that of the standard drug, diclophenac sodium (46.69%). The two extracts EAS and RES was found to have good anti-inflammatory activity as compared to standard drug. Conclusions: Thus the plant can be used as a potential anti-inflammatory candidate in animals.

Objective: To address the association of dietary vitamins, anthropometric profile, lipid profile, antioxidant enzymes and lipid peroxidation in hypertensive participant compared with normotensive healthy controls.Methods:in both hypertensive participants and normotensive age-sex matched healthy controls. The associated changes in serum antioxidants and lipid peroxidation were also assessed along with lipid profile and anthropometric measurements in both groups of subjects under study.Results:Dietary intake of vitamins was assessed by 131 food frequency questionnaire items B2 and ascorbic acid compared to normotensive controls. Anthropometric variables in the hypertensive showed significant differences in weight, body mass index, waist circumference, hip circumference, waist-hip ratio and mid-arm circumference. The total cholesterol, low-density lipoprotein cholesterol, triglyceride were significantly higher (P<0.001) in hypertensive except high-density lipoprotein cholesterol which was significantly higher (P<0.001) in normotensive. The serum endogenous antioxidants and enzyme antioxidants were significantly decreased in hypertensive except serum albumin levels compared to normotensive along with concomitant increase in serum lipoprotein (a) malondialdehyde and conjugated diene levels. Dietary vitamins intake was higher in hypertensive participants excepting for vitamin Conclusions: Based on the observations, our study concludes that hypertension is caused due to interplay of several confounding factors namely anthropometry, lipid profile, depletion of endogenous antioxidants and rise in oxidative stress.

Carotid Body Tumor ; diagnosis ; Humans ; Male

Cholangiocarcinoma ; pathology ; Female ; Fluorodeoxyglucose F18 ; pharmacology ; Humans ; Positron-Emission Tomography ; methods ; Soft Tissue Neoplasms ; pathology ; Tomography, X-Ray Computed ; methods

Objectives: The concept of “Abnormal illness behavior (AIB)” has been evolved to a greater extent in the last century. Henry Sigerist introduced the concept of “illness behavior” in 1929. Mechanic & Volkart defined and further conceptualized the impression on illness behavior. Talcott Parson had given the concept of “Sick role,” and Issy Pilosky had familiarized the notion of “abnormal illness behavior.” The main objective of this article is to review the conceptual evolution on “abnormal illness behavior” and to analyze its current clinical implications. Methods: Extensive search of literature was performed regarding abnormal illness behavior, illness behavior and sick role in online web searching sites like – Google Scholar, PubMed and individual journal sites as well as google books. The literature was critically reviewed with personal inputs from authors. Results: Abnormal illness behavior ranges from denial of illness in one extreme to conscious amplification of symptoms on the other. Abnormal illness behavior is noticed in various clinical conditions like stress-related disorder, stress-related disorders, factitious disorder and malingering. Conclusions: Identifying abnormal illness behavior can prevent unnecessary and excessive utilization of medical aids for the same.

Plants are used as medicine since ancient time, in organized (Ayurveda, Unani & Siddha) and unorganized (folk, native & tribal) form. In these systems, drugs are described either in Sanskrit or vernacular languages. Avartani (Helicteres isora Linn.) is a medicinal plant which is used in several diseases. It is commonly known as Marodphali, Marorphali, Enthani etc. due to screw like appearance of its fruit. Avartani is used as a folk medicine to treat snake bite, diarrhoea and constipation of new born baby. In the research, antioxidant, hypolipidaemic, antibacterial and antiplasmid activities, cardiac antioxidant, antiperoxidative potency, brain-antioxidation potency, anticancer activity, antinociceptive activity, hepatoprotective activity, anti-diarrheal activity and wormicidal activity in this plant were reviewed.

Holoptelea integrifolia Roxb. (Indian Elm) is a very useful and popular traditional medicinal plant in India. During the last three decades, apart from the chemistry of plant compounds, considerable progress regarding the biological activity and medicinal applications of Indian Elm has been achieved. Ethno-medically, the leaves and stem bark of this plant have been used by tribes as antiviral, antioxidant, antimicrobial, abortifacient preparations and in the management of cancer. Recent studies on plant show that it has potential to fight against tumor and obesity as well. Phytochemical investigation shows the presence of chemical constituents such as terpenoids, alkaloids, glycosides, carbohydrates, steroids, sterols, saponins, tannins, proteins and flavanoids. The isolated principles such as β-amyrin, β-sitosterol, holoptelin-A, holoptelin-B, hederagenin, hexacosanol, β-D-glucose, friedelin, epifriedelin, 2-amino naphthoquinone, 1,4-naphthalenedione, are considered as responsible for various activities. This review highlights the traditional uses, reported biological/pharmacological activities, isolated compounds and therapeutic applications of Holoptelea integrifolia which might be helpful for scientists and researchers to find out new chemical entities responsible for its claimed traditional uses.