This study reports the results of 730 cases of psoriasis vulgaris follow ed up for 20-30 years. The data revealed thatm ostpatients relieved to som e extentduring the courses,in som e patients skin lesions even com pletely disappeared for a long period, and only in few cases skin lesions rem ained severe for a long period. There w ere 6 patterns of courses after the first attack of psoriasis vulgaris. The use of antineoplastic drugs for treating psoriasis m ay have negative effect in the long run.