Objective To retrospectively analyze the status quo of health education for domestic hypertensive patients in the past 10 years.Methods Papers on health education for domestic hypertensive patients, retrieved from Wanfang Database and CNKI, were analyzed according to the Excel.Results The number of studies on health education for domestic hypertensive patients showed a tendency to increase in 2005-2015.The commonly used health education methods for hypertensive patients were face to face education, distributing education materials, holding lectures, and follow-up.The main health education contents included hypertension-related knowledge, physical exercises, rational diet, emotion control, compliant behaviors, giving up smoking and limiting drinking, and body weight control.The index of lifestyle of patients was improved after health education.Conclusion Great achievements are made in health education for hypertensive patients in our country.Stress should be placed on the rational planning for health education and building electronic health education platform in future.

Objective: To observe the nuclear DNA contents and expression of p53 protein in epithelial ovarian tumors (EOT) and to explore their correlation with CT images and prognosis in EOT patients. Methods: The nuclear DNA contents, expression of p53 protein and CT findings of 88 EOT patients were analyzed. Twenty-six EOT patients were followed up and were divided into AT group (ancuploid, n=19) and DT group (diploid, n=7) according to DNA ploid, and into p53 protein (+) group (n=15) and p53 protein (-) group (n=11) according to expression of p53 protein. The correlation of nuclear DNA content and p53 protein expression with CT findings and prognosis of EOT patients was analyzed. Results: The DNA index, patient number with AT and protein p53 (+) rate were significantly different between patients with their cystic wall thickness ≥ 3 mm and <3 mm, patients with and without cystic wall nodus, and patients with poorly-defined tumor boundary and well-defined tumor boundary in 88 patients with EOT( P<0. 01). The "enhanced degree of tumor parenchyma" in AT group was obviously higher than that in DT group(P<0. 01) , and was similar between protein p53 (+) group and (-) group. The survival periods of patients in DT group and protein p53 (-) group were longer than those in AT group and protein p53 (+) group (P<0.05, P<0.01). The survival periods of 12 patients in AT group with p53 protein (+) expression were all less than 48 months. Conclusion: Nuclear DNA and p53 protein are correlated with CT findings in EOT patients; the prognosis of ovarian carcinoma with aneuploidy and/or p53 protein (+) expression is poor.

Aromataseinhibitors(AI)aretheleadingcarefortheadjuvanttreatmentofhormone responsive carcinoma of the breast as demonstrated in a number of large international phase III randomised tri-als.Aromatase inhibitor-associated arthralgia (AIA )was a somewhat unexpected side effect of this class of agents and has proven to be potentially problematic in clinical practice.The pathogenesis of AIA is not very clear currently,with the cause of most research focusing on estrogen deprivation,immune abnormalities,tenosy-novial changes and joint effusions.It is extremely urgent that we evaluate this syndrome and select appropriate therapeutic strategies to reduce the incidence of AIA,thereby improving breast cancer-related outcomes.

Obesity increases the risk of ovarian cancer,and it is associated with the poor prognosis of ovarian cancer.Its pathogenic mechanism may be associated with the increased level of serum estrogen,insulin and insulin-like growth factors-1 induced by obesity and a variety of adipocytokines,which has an impact on the therapeutic result and prognosis of ovarian cancer.Maintaining a proper weight may prevent the development of ovarian cancer.

Objective To investigate the clinical features,therapeutic methods,therapeutic effect and prognosis of a case of bladder urothelial carcinoma patients in combination with trophoblast.Methods The pathological data of a patient with bladder high grade urinary epithelial carcinoma in combination with trophoblast was retrospectively analyzed and the related literatures were reviewed.It was a male patient,69 years old,presenting with total painless gross hematuria.The CT scan showed irregular nodules on the anterior wall of bladder.Results Cystoscopy showed 1.5 cm cauliflower mass on the anterior wall of bladder,and transurethral resection of bladder tumor was performed.The pathology and immunohistochemistry showed urothelial carcinoma.Lung metastases was found due to hemoptysis,and increased serum beta human chorionic gonadotropin (β-HCG) was detected simuhaneously.Pathology was double checked and bladder urothelial carcinoma with trophoblast cell differentiation was considered.Three cycles gemcitabine + cisplatin (GC regimen) and 2 cycles etoposide + methotrexate + vincristine + cyclophosphamide (modified EMA-CO regimen) therapies were given,and the disease was stable at that time.The patient died on June 10,2016,and the total survival period was 9 months.Conclusions The clinical and imaging of urothelial carcinoma with trophoblast differentiation is not special.Diagnosis must depend on the pathological and immunohistochemistry examinations.The efficacy can be evaluated by combining imaging with serumβ-HCG.Treatment should be systemic venous chemotherapy.

Objective To investigate the clinical significance of CA242 combined with TGF-? to diagnose adenocarcinoma of pancreas.Methods Thirty patients were involved in this study,who were hospitalized from Dec.2004 to Sept.2005.ELISA was used both to investigate the expression of CA242 in 30 cases and TGF-? in 20 cases.Twenty healthy volunteers were as controls.Results CA242 was increased in adenocarcinoma of pancreas compared with controls[(312?5)kU/L vs(56?2)kU/L,P0.05.Conclusion The specificity of each of CA242 and TGF-? to diagnose adenocarcinoma of pancreas is high.The sensitivity of TGF-? is higher than that of CA242.CA242 combined with TGF-? can increase the diagnosis rate of adenocarcinoma of pancreas.

Objective To probe the mechanism of metronidazole resistance to Helicobacter pylori (Hp). Methods (1) The selective pressure test of metronidazole. (2) SDSPAGE electrophoresis. (3) Nitrate reduction test. (4) Test for detecting the enzyme activities associated with 95 substrates of gram negative. Results After the mutation of Hp from sensitive to resistant strains, the activities of enzymes associated with monomethyl succinate, succinic acid and Dalanine is decreased, and those associated with Lfucose 6phosphate glucose is increased. Conclusions The metronidazole resistance of Hp is associated with the metabolism and the change of enzyme activities.

Animals ; Apigenin ; pharmacology ; Female ; Follicle Stimulating Hormone ; blood ; Gonadotropin-Releasing Hormone ; blood ; Luteinizing Hormone ; blood ; Phytoestrogens ; pharmacology ; Rats

Objective To investigate the value of endoscopic ultrasonograghy (EUS) in diagnosis and treatment of gastrointestinal neuroendocrine neoplasm (GI-NEN).Methods We retrospectively summarized the clinical data of 44 patients with GI-NEN which were confirmed by pathology and immunohistochemistry,and analyzed the EUS features and the follow-up data of patients who received EUS exam and EUS-assisted endoscopic resection.Results A total of 47 neoplasms were detected in 44 patients,in which 41 were confirmed as neuroendocrine tumors (NET) and 6 were neuroendocrine carcinoma (NEC).Under EUS,all 41 NET appeared as hypoechoic lesions with regular edge and homogeneous echographic pattern,and 18 were originated from mucosal layer and 23 from submucosal layer,which was all confirmed by pathological evaluation.All 41 NET lesions received EUS-assisted endoscopic resection,in which 17 were treated by ESD/EMR and 24 by high frequency electrotomy.Follow-up endoscopy was performed at 3-6 and 12 month after operation,which showed no residual or recurrence.Conclusion EUS may accurately determine the invasion depth of GI-NEN lesions,and provide important information for adapting appropriate treatment strategies,which has highly clinical practice value in the diagnosis and treatment of GI-NEN.

Objective: To detect the expression of CDX2, COX-2, and NF-κB in the tissues of gastric carcinoma (GC), precancerous lesions, and normal gastric mucosa and to in vestigate the correlation among CDX2, COX-2, and NF-κB. Methods:Data on the expression of CDX2, COX-2, and NF-κB were evaluated using immunohistochemistry in 60 cases with GC, 45 cases with precancerous lesions, and 20 cases with normal tissues. The protein levels in different pathological tissues, as well as their correlation with GC, were analyzed. Results:The positive rates of NF-κB and COX-2 proteins were significantly higher in GC group than those in precancerous lesion and normal tissue groups (P<0.05). CDX2 was expressed in GC and precancerous lesion groups but poorly expressed in the normal mucosa. The positive rate of CDX2 expression was significantly higher in precancerous lesion group than that in GC group (P<0.01). NF-κB expression was positively correlated with COX-2 in GC (P<0.01), whereas CDX2 expression was negatively correlated with COX-2 and NF-κB in GC (P<0.01). Conclusion:CDX2, COX-2, and NF-κB are possibly correlated with one another, and they cooperate during the onset, progression, and metastasis of GC.