ObjectiveTo study the effects of the sand therapy of Uyghur Traditional Medicine on cytokines,such as interleukin-1β(IL-1β), tumor necrosis factor-α(TNF-α), nitric oxide(NO) of the rabbit experimental knee osteoarthritis. Methods27 rabbits were injected papain into the joint space of right knee, and divided randomly into three groups. 15 d after the articular injection, the rabbits of group Ⅰ were treated with the sand therapy, the rabbits of group Ⅱ were treated with fenbid, and Ⅲ group accepted no treatment for the blank control.15 d after treatment, the serum and the douche fluid of the diseased joints were obtained to measure the level of IL-1β,TNF-α and NO. The synovium and the cartilage was observed histopathologically.ResultsCompare with group Ⅱ and Ⅲ, the pathological changes of cartilage and synovitis in group Ⅰ lighten significantly. Compare with groupⅢ,the level of IL-1β, TNF-α in articular douche fluid and NO in serum of group Ⅰ and Ⅱ decreased significantly. ConclusionThe sand therapy can decrease the level of cytokines in the focus joints, which may play a role of treatment in osteoarthritis.

Objective To explore the clinical features and risk factors of primary gout in Xinjiang area.Methods A total of 364 patients with gout and 546 healthy crowd were divided into two groups.A unified questionnaire was used to investigate and detect relevant biochemical indicators.Related biochemical indexes were examined and analyzed.Logistic regression model was established to analyze the risk factors related to gout.Results The mean age of onset of gout was 42.95±11.93.More than two joints were involved in56.32％ of patients with gout.BMI, SUA, GLU, BUN, CREA, TG, TC, LDL-C of gout group were significantly higher than those of control group (P＜0.01), while HDL-C was significantly lower than that of control group (P＜0.01).The advanced age, high uric acid hematic disease, high blood pressure, high blood sugar, smoking, drinking, family history of gout, BMI, high TG levels, and high creatinine hematic disease, high blood LDL-C may be risk factors for gout occurence (OR=3.767, 103.482, 3.621, 2.934, 3.140, 3.482, 4.198, 1.102, 1.498, 1.102, 1.498), while aerobic exercise regularly (three times or more a week) is the protection factor gout occurs.Conclusion The average age of patients with gout in Xinjiang is lower than the national level.The distribution of the degree of culture of patients with gout in Xinjiang may have no obvious rule, and the population with medium and low degree of culture is the main affected population.More than half of patients with gout are now involved in more than two joints.The most common associated with gout is hypertension.Beer/liquor and high-fat diet are the most common dietary factors for patients with gout in Xinjiang.The advanced age, hyperuricemia, hypertension, hyperglycemia, smoking, drinking, hypercreatinine, BMI, high-TG, high LDL-C and family history of gout may all increase the risk of gout, while aerobic regular exercise (more than 3 times per week) may reduce the risk of gout.