1.Acute renal infarction secondary to membranous glomerulopathy.
Frederick E. OGBAC ; Kristine T. GAPUZ ; Cherisse Ann P. PANLILIO ; Alicia N. BALDONADO
Philippine Journal of Internal Medicine 2017;55(1):1-4
BACKGROUND: Acute renal infarction often presents with abdominal pain, nausea, vomiting, and fever.With other more common illnesses presenting with the same symptoms,
it is often misdiagnosed leading to delayed treatment.We present a case of a young female diagnosed to have Membranous Glomerulopathy who presented with sudden onset flank pain in whom was initially treated as urinary tract infection.
CASE: A 19-year-old female diagnosed with membranous glomerulopathy presented at the Emergency Room (ER) with severe, right sided, flank pain of acute onset, associated with nausea and vomiting. No fever, dysuria, hematuria, or history of trauma. Her vital signs were within normal range. Abdominal examination revealed a distended but soft non-tender abdomen with positive shifting dullness and fluid wave test. Right sided costovertebral angle tenderness was elicited.Initial diagnostics showed leukocytosis with neutrophilic predominance, serum creatinine of 0.77mg/dL, and proteinuria of >600mg/dL.Abdominal ultrasound showed non-specific findings, thus contrast-enhanced computed tomography scan (CT-Scan) of the abdomen was done which revealed areas of non-enhancement in the upper to middle portions of the right kidney which may relate to areas of ischemia and/or infarction, likely due to thrombosis involving the more distal portion of the right renal artery and massive ascites. Result was confirmed by computed tomography angiography (CTA) of the kidneys showing right renal artery thrombosis. Evaluations for other causes of renal artery thrombosis aside from patient's concurrent membranous glomerulopathy were done and were negative. Anti-coagulation therapy was initiated using low molecular weight heparin (LMWH) and was thereafter maintained on warfarin.
CONCLUSION: A high index of clinical suspicion is needed to diagnose acute renal infarction because of its non-specific symptoms which can mimic other conditions. Early diagnosis and prompt initiation of anti-coagulation therapy is important to avoid irreversible kidney damage. Acute renal infarction should be considered as a cause of acute onset flank pain in patients with risk factors and normal initial screening test.
Human ; Female ; Adult ; Glomerulonephritis, Membranous ; Heparin, Low-molecular-weight ; Warfarin ; Hematuria ; Creatinine ; Renal Artery ; Dysuria ; Leukocytosis ; Kidney ; Kidney Diseases ; Proteinuria ; Urinary Tract Infections ; Infarction ; Flank Pain ; Case Reports