No abstract available.
Kidney Diseases* ; Kidney* ; Liver Transplantation* ; Liver* ; Pathology*

Biopsy, Needle ; methods ; China ; Humans ; Kidney ; pathology ; Kidney Diseases ; pathology ; Kidney Neoplasms ; pathology ; Specimen Handling

The kidneys can be damaged by a large number of therapeutic agents. The aim of this article is to discuss the pathological features of drug-induced renal disease as diagnosed by kidney biopsy. The literature is reviewed and cases seen by the authors that have a known drug association are analysed. Mechanisms of injury are varied and all renal structures may be affected. The tubulointerstitial compartment is most frequently involved, but glomerular and vascular lesions are seen in a significant proportion of cases.
Humans ; Kidney Diseases ; chemically induced ; pathology

Biopsy ; methods ; Glomerulonephritis, IGA ; pathology ; Humans ; Kidney ; pathology ; Kidney Diseases ; pathology ; Lupus Nephritis ; pathology

To analyze the nuclei in the glomeruli of human kidneys, the problem of miss extraction or wrong extraction of nuclei caused by the effects of many factors during making slice must be solved. Aiming at this question, this paper proposed a dynamic thresholding method using eigenvalue feedback strategy based on multicenter. First, according to the information of R channel in the RGB color space and the information of C channel in the CMYK color space, after the process of filtering by LOG, we can get the correct positions of nuclei. Second, adjusting the threshold value surface by eigenvalue feedback strategy, we can solve the problem of conglutination of different nuclei. Then by combining the position information of nuclei, we can realize the nuclei segmentation accurately. The experimental results have demonstrated the high precision of this method.
Biopsy, Needle ; Cell Nucleus ; pathology ; Humans ; Image Processing, Computer-Assisted ; Kidney Diseases ; pathology ; Kidney Glomerulus ; pathology

To investigate the effects of mycophenolate mofetil (MMF) on the process of renal interstitial fibrosis, unilateral ureteral obstruction (UUO) model was established in rats. Twenty Sprague-Dawley rats underwent UUO and received vehicle (n = 10) or MMF (20 mg.kg-1.d-1, by daily gastric gavage, n = 10) during a period of 5 days following surgery, and the additional 10 rats were served as sham-operated group. The rats were killed 5 days after surgery. Immunohistochemistry was performed on renal tissue for proliferating cell nuclear antigen (PCNA), alpha-smooth muscle actin (alpha-SMA) and type I and III collagen (col I, col III). Histological studies were also done by MASSON staining. Five days after surgery, proliferating cells in tubules, interstitium as well as interstitial myofibroblast (MyoF) infiltration and interstitial col I, col III deposition were all significantly reduced by MMF treatment. MMF also alleviated the histological changes of UUO rats. These results suggested that the reduction of interstitial MyoF infiltration may be an important event by which MMF prevents renal injury caused by UUO and MMF could be used to limit the progression of renal fibrosis.
Fibrosis ; Kidney/*pathology ; Kidney Diseases/etiology ; Kidney Diseases/pathology ; Kidney Diseases/*prevention & control ; Mycophenolic Acid/*analogs & derivatives ; Mycophenolic Acid/*pharmacology ; Random Allocation ; Rats, Sprague-Dawley ; Ureteral Obstruction/*complications

Multicystic dysplastic kidney is the most frequent cause of abdominal mass in the neonate, but its presentation is variable depending on the size of cystic kidney, state of the opposite kidney and associated anomalies. multicystic dysplastic kidney also represents a spectrum of pathology from unilateral multicystic kidney through segmental and focal multicystic dysplasia to bilateral multicystic kidney. Herein we report 5 cases of MCK with different presentation and histology, a bilateral MCK associated with horseshoe kidney, a large MCK with uremia, a focal segmental MCK with contralateral UPJ obstruction, a small focal segmental MCK with contralateral megaureter and a small MCK detected by ultrasonogram for localization of impalpable testis.
Humans ; Infant, Newborn ; Kidney ; Kidney Diseases, Cystic ; Multicystic Dysplastic Kidney* ; Pathology ; Testis ; Ultrasonography ; Uremia

Renal disease includes conditions affecting the glomeruli, tubules, interstitium, pelvis, and vasculature. Diseases of the kidney include glomerular diseases, diseases of the tubules and interstitium, diseases of renal pelvis, and developmental abnormalities. Renal tissue samples (n = 70) submitted to the Department of Veterinary Pathology of Konkuk University from 2003 to 2008 were included in this study. Tissue histopathology was performed using light microscopy with hematoxylin and eosin stains. Masson's trichrome, Congo Red, and Warthin starry silver staining were applied in several individual cases. Glomerular diseases (22.9%), tubulointerstitial diseases (8.6%), neoplastic diseases (8.6%), conditions secondary to urinary obstruction (24.3%), and other diseases (35.7%) were identified. Glomerulonephritis (GN) cases were classified as acute proliferative GN (5.7%), membranous GN (4.3%), membranoproliferative GN (4.3%), focal segmental GN (2.9%), and other GN (4.2%). The proportion of canine GN cases presently identified was not as high as the proportions identified in human studies. Conversely, urinary obstruction and end-stage renal disease cases were relatively higher in dogs than in human populations.
Animals ; Dog Diseases/*pathology ; Dogs ; Female ; Humans ; Kidney/*pathology ; Kidney Diseases/pathology/*veterinary ; Male ; Republic of Korea ; Retrospective Studies

Biopsy ; Cryopreservation ; Frozen Sections ; Humans ; Kidney ; pathology ; Kidney Diseases ; pathology ; Paraffin Embedding ; methods

To improve the understanding of lipoprotein glomerulopathy, the clinical data of a single case of lipoprotein glomerulopathy, diagnosed at the Second Xiangya Hospital, Central South University in June 2011, were retrospectively analyzed. The analysis included clinical manifestation, laboratory results, and pathological information on kidney biopsy. Nephrotic syndrome was seen as the major clinical feature in this patient. Levels of serum apoE and apoB were increased. Obvious expansion of glomerular capillary cavities, filled with a weakly stained thrombus-like substance, were observed. ApoE immunohistochemical staining showed positive staining in capillary luminal contents. Transmission electron microscopy revealed capillary lumina occluded by various foaming lipid depositions in clustered or layered arrangement. There were no special symptoms nor obvious abnormal laboratory results of the LPG patient. Diagnosis of LPG should be based on clinical manifestations and renal biopsy. Characteristic pathological performance plays an important role in the diagnosis of lipoprotein glomerulopathy.
Adult ; Biopsy, Needle ; Humans ; Kidney ; pathology ; ultrastructure ; Kidney Diseases ; diagnosis ; pathology ; Male