Objective To optimize the suitable method of ultra-try and pre-humidity for Scutellaria baicalensis seeds. Methods Taking S. baicalensis seeds as experimental materials, the seeds were dried by silica gel in a certain proportion on the constant temperature 30 ℃ in the desicator to obtain the seeds of S. baicalensis with various ultra dried moisture The proper moisture of ultra dry for S. baicalensis seeds was evaluated by measuring the germination percentage, germination energy, etc.The optimized pre-humidity was studied by six kinds of pre-humidifications. Results The optimum ultra-dry moisture of S. baicalensis seeds was 3.6%. The viability of S. baicalensis seeds decreased significantly while the ultra-dry moisture was 2.6%. The viability of S. baicalensis seeds damaged by ultra-dry was improved by PEC 30% pre-humidification. Conclusion The S. baicalensis seeds can be kept in a good quality by reducing the moisture with the ultra-dry method.