1.Homeopathic Thuja 30C ameliorates benzo(a)pyrene-induced DNA damage, stress and viability of perfused lung cells of mice in vitro.
Mukherjee, Avinaba ; Boujedaini, Naoual ; Khuda-Bukhsh, Anisur Rahman
Journal of Integrative Medicine 2013;11(6):397-404
To examine if the ultra-highly diluted homeopathic remedy Thuja 30C can ameliorate benzo(a)pyrene (BaP)-induced DNA damage, stress and viability of perfused lung cells of Swiss albino mice in vitro.
2.Oleanolic acid isolated from ethanolic extract of Phytolacca decandra induces apoptosis in A375 skin melanoma cells: drug-DNA interaction and signaling cascade.
Ghosh, Samrat ; Bishayee, Kausik ; Khuda-Bukhsh, Anisur Rahman
Journal of Integrative Medicine 2014;12(2):102-14
Oleanolic acid (OA) has been reported to have anticancer effects, but the extent of its cytotoxicity, its ability to interact with nuclear DNA, its action against skin melanoma, as well as the molecular mechanism of its action against cell proliferation and in support of cell death are still unexplored. This led us to examine the efficacy of OA, a bioactive compound isolated from Phytolacca decandra, on these issues in the present investigation.
3.Evaluation of chemopreventive potentials of ethanolic extract of Ruta graveolens against A375 skin melanoma cells in vitro and induced skin cancer in mice in vivo.
Ghosh, Samrat ; Sikdar, Sourav ; Mukherjee, Avinaba ; Khuda-Bukhsh, Anisur Rahman
Journal of Integrative Medicine 2015;13(1):34-44
Chemopreventive approach with natural products, particularly plants and plant-derived ones, is receiving increasing attention for their effective role against cancer without any palpable side effects. In this study, efficacy of ethanolic extract of Ruta graveolens (RG) on skin melanoma cells (A375) in vitro and on 7,12-dimethylbenz(a)anthracene (DMBA)-induced skin cancer in vivo has been tested in Swiss albino mice.
4.Phenotypic evidence of ultra-highly diluted homeopathic remedies acting at gene expression level: a novel probe on experimental phage infectivity in bacteria.
Saha, Santu Kumar ; Das, Sreemanti ; Khuda-Bukhsh, Anisur Rahman
Journal of Integrative Medicine 2012;10(4):462-70
To explore if some ultra-highly diluted homeopathic remedies claimed to have antiviral effects can demonstrate any discernible action in the bacteria Escherichia coli through modulating infectivity potentials of the bacteriophage φX174 DNA.
5.Potentized homeopathic drug Arsenicum Album 30C inhibits intracellular reactive oxygen species generation and up-regulates expression of arsenic resistance gene in arsenine-exposed bacteria Escherichia coli.
De, Arnab ; Das, Durba ; Dutta, Suman ; Chakraborty, Debrup ; Boujedaini, Naoual ; Khuda-Bukhsh, Anisur Rahman
Journal of Integrative Medicine 2012;10(2):210-27
To examine if potentized homeopathic drug Arsenicum Album 30C (Ars Alb 30C) can reduce sodium arsenite-induced toxicity in Escherichia coli.
6.Anticancer potentials of root extract of Polygala senega against benzoapyrene-induced lung cancer in mice.
Paul, Saili ; Bhattacharyya, Soumya Sundar ; Samaddar, Asmita ; Boujedaini, Naoual ; Khuda-Bukhsh, Anisur Rahman
Journal of Integrative Medicine 2011;9(3):320-7
To evaluate anticancer potentials of Polygala senega on lung cancer induced by benzo[a]pyrene (B[a]P) in mice.
7.Potential of the homeopathic remedy, Arnica Montana 30C, to reduce DNA damage in Escherichia coli exposed to ultraviolet irradiation through up-regulation of nucleotide excision repair genes.
Das, Sreemanti ; Saha, Santu Kumar ; De, Arnab ; Das, Durba ; Khuda-Bukhsh, Anisur Rahman
Journal of Integrative Medicine 2012;10(3):337-46
To examine to what degree an ultra-highly diluted homeopathic remedy, Arnica Montana 30C (AM-30C), used in the treatment of shock and injury, can modulate the expression of nucleotide excision repair genes in Escherichia coli exposed to ultraviolet (UV) irradiation.
8.Ameliorative potentials of Syzygium jambolanum extract against arsenic-induced stress in L6 cells in vitro.
Samadder, Asmita ; Das, Jayeeta ; Das, Sreemanti ; Biswas, Raktim ; Khuda-Bukhsh, Anisur Rahman
Journal of Integrative Medicine 2012;10(11):1293-302
To determine the ameliorative potentials of Syzygium jambolanum (SJ) extract in L6 skeletal muscle cells in regard to arsenic-induced impairment of optimum glucose homeostasis and improper functioning of mitochondria.
9.Dihydroxy-isosteviol methyl ester of Pulsatilla nigricans extract reduces arsenic-induced DNA damage in testis cells of male mice: its toxicity, drug-DNA interaction and signaling cascades.
Samadder, Asmita ; Das, Jayeeta ; Das, Sreemanti ; Das, Durba ; De, Arnab ; Bhadra, Kakali ; Khuda-Bukhsh, Anisur Rahman
Journal of Integrative Medicine 2012;10(12):1433-42
To evaluate the ameliorative efficacy of dihydroxy-isosteviol methyl ester (DIME) of Pulsatilla nigricans extract in arsenic-induced DNA damage in testis cells of mice.
10.Ethanolic extract of Thuja occidentalis blocks proliferation of A549 cells and induces apoptosis in vitro.
Mukherjee, Avinaba ; Sikdar, Sourav ; Bishayee, Kausik ; Paul, Avijit ; Ghosh, Samrat ; Boujedaini, Naoual ; Khuda-Bukhsh, Anisur Rahman
Journal of Integrative Medicine 2012;10(12):1451-9
To study the possible anticancer and antiproliferative activities of ethanolic leaf extract of Thuja occidentalis (TO) on A549 non-small lung carcinoma cells in vitro.