Objective To reconstruct the oral and maxillofacial defects with the radial forearm flaps. Methods 12 patients suffered from the oral and maxillofacial soft tissue defects caused by various reasons had undergone the reconstruction by microsurgical techniques to implant the free radial forearm flaps for repair of the defects. Assessment was given to the results of the reconstructions of the oral and maxillofacial defects. Results The appearance, plump and countenance functions of the maxillofacial region were regained. The oral functions were improved obviously. 11 of 12 patients’ defects (91.66%) were reconstructed successfully. Conclusion The radial forearm flap is an excellent option especially for the repair and reconstruction of the oral and maxillofacial multiple-angle, irregular and complicated defects.