Objective To explore the relationship between the liver fibrosis scales of B-ultrasound and the serological indicators of schistosomiasis liver fibrosis for guiding clinical diagnosis and treatment. Methods A total of 206 schistosomiasis patients including the acute, chronic and advanced were classified by ultrasonic evidences, and serological indicators of liver fibrosis were detected. The correlation among them was analyzed statistically. Results Ultrasonic diagnosis was 0 scale for acute group and control group, and Ⅱscale for chronic group, as well as Ⅲ scale for advanced group. Advanced group had the highest level of 4 serum indicators of liver fibrosis, and chronic group ranked the middle level, and acute group had the lowest level. The more advanced the ultrasonic scales of liver fibrosis, the higher level the 4 serum indicators. Conclusions There is a consistency relationship between ultrasonic classifications of liver fibrosis and serological indicators in schistosomiasis patients. It also conforms to clinical diagnosis. When ultrasound is applied in schistosomiasis, serological detection is essential and it could make up for the shortage of ultrasonic findings and give better guidance for clinical diagnosis and treatment.

Objective To test the impact of age, education and gender on the Chinese Version of the Test of Everyday Attention (TEA).Methods 117 normal volunteers were selected. They were grouped by age and education. After screening of Montreal Cognitive Assessment (MoCA), the volunteers were administered to the TEA (version A). Correlation analysis was performed between age and education with TEA. Comparisons between groups were tested in gender. Results There were significant correlations between most subtests with age except elevator counting, visual elevator counting (VE1) and lottery task. Education correlated with map search and elevator counting with reversal in the youth group. There were correlation between visual elevator (VE2) and telephone search while counting with education in the young and middle-aged group. Education related to map search, visual elevator (VE1, VE2), elevator counting with reversal, and telephone search in the middle-aged group. The subtests were not statistically different between different gender groups except telephone search. Conclusion Age and education had effect on TEA while Gender had no significant effect.

This review summarized the important theory of attention and summed the attention assessment Methods and applications during the recent 50 years. In the future the field of neurological rehabilitation research in attention and attention assessment had been discussed.

Objective To explore the reliability and validity of the Chinese version of the Test of Everyday Attention (TEA) in normal Chinese people. Methods 117 normal volunteers (18～65 years old) were screened with the Montreal Cognition Assessment (MoCA), and the normal volunteers were administered to TEA (versions A), Trail Making Test B (TMT-B), Paced Auditory Serial Addition Task (PASAT), Stroop Color-Word Interference Test (SCWT), Continuous Performance Test (CPT). 20 normal volunteers were also given version B for testing of the test-retest reliability, time interval was 2 weeks between versions A and B. Results There was correlation between versions A and B in the major subtests (r>0.700, P<0.01) at a two-week interval. The varimax rotation principal-component analysis extracted 4 component factors, namely sustained attention, se lective attention, switching attention, and divided attention. The factors included various subtests of TEA and the other laboratory attentional test. Conclusion TEA has good reliability and validity.

NK/T cell lymphoma is a distinct clinicopathologic entity which is more prevalent in Asia than in America and Europe and is highly associated with Epstein-Barr virus (EBV) infection. Although the clinicopathologic features of the tumor have been clearly defined, genetic changes and roles of virus associated with the development and progression of tumor have not been well studied. In this study, we carried out polymerase chain reaction (PCR) for EBNA-3B, EBNA-3C, and LMP-1 30 bp deletion to investigate EBV subtype and variants in tumor tissue and performed comparative genomic hybridization (CGH) to screen chromosomal imbalances using frozen tissues from 7 patients with nasal-type NK/T cell lymphoma and 1 patient with blastic NK cell lymphoma. Of 6 cases infected with EBV, there were EBV type 1 in six, LMP-1 30 bp deletion variant in four, and LMP-1 40 bp deletion variant in one. Frequent chromosomal imbalances included deletions at 1p31-pter (4), 12q23-q24 (3), and 17p (4), and gains at 2q (5), 10q (3), and 13q34-qter (4). Blastic NK cell lymphoma displayed deletions of 9q, 7q, and 6q, similar to that of nasal-type NK/T-cell lymphoma. With these results, we assumed that candidate genes in these imbalanced chromosomal loci would provide the clue for further molecular studies to identify putative tumor suppressor genes or proto-oncogenes associated with pathogenesis of this neoplasm.
Americas ; Asia ; Comparative Genomic Hybridization* ; Europe ; Genes, Tumor Suppressor ; Genotype* ; Herpesvirus 4, Human* ; Humans ; Killer Cells, Natural ; Lymphoma* ; Polymerase Chain Reaction ; Proto-Oncogenes

Hypothyroidism is a common endocrine disease.Its treatment depends on thyroid hormone replacement therapy.Currently,levothyroxine (L-T4) is the preparation recommended by many guidelines.However,there are some L-T4-treated patients with normal TSH levels and persistent non-specific symptoms and discomforts.Therefore,combination therapy with L-T4and liothyronine (L-T3) has been considered as an alternative option for hypothyroidism.However,more prospective studies are needed to provide evidence-based effects for this kind of regimen.

In recent years, the theory of cancer stem cells has provided a new perspective on the treatment of cancers including breast cancer. The accurate sorting of breast cancer stem cells is critical. The sorting procedure is consist of 4 steps: isolation of side population, serum-free suspension culture,determination of specific cell surface markers and of the activity of aldehyde dehydrogenase 1 ( ALDH1 ) enzymatic through the ALDEFLUOR assay. Some studies choose drug resistance as an additional method for sorting cancer stem cells because of the enrichment of cancer stem cells after chemotherapy . The controversy about the sorting outcome of breast cancer stem cell mainly focus on molecular markers like CD44+ CD24- and ALDH1+ . The problem needed to be settled is to identify which sorting method and markers are appropriate.

Objective To investigate the relationship among peroxisome proliferators - activated receptor gamma (PPAR-γ), pul-monary arterial systolic pressure(PASP) ,and insulin resistance in Chronic Obstructive Pulmonary Disease (COPD) patients. Methods A-mong 63 COPD patients, 30 patients with level of PASP above 40mmHg were enrolled in PAH group and other 33 patients were enrolled in COPD group. Twenty healthy medical examination subjects were enrolled in control group. The expression of PPAR-γ, mRNA was detected by real time fluorescent quantitative RT- PCR. Radioimmunoassay was used to measure the level of fasting plasma insulin (FIN). Fasting plas-ma glucose (FPG) was detected by glucose oxidase method. Results The expression of PPAR-γ mRNA was significantly decreased in PAH and COPD group, while FPG, FIN and IRI increased significantly. PAH group had more increased PASP, decreased expression of PPAR-γ and higher IRI than COPD group. Expression of PPAR-γ was negatively related to PASP and IRI. Conclusions The significantly down reg-ulated expression of PPAR-γ maybe explain the higher FPG and PASP.

Dental Clinics ; Emergency Treatment ; Humans ; Hypersensitivity

Dental Care ; Dental Clinics ; Emergencies ; Humans