Objective To explore the relationship between the liver fibrosis scales of B-ultrasound and the serological indicators of schistosomiasis liver fibrosis for guiding clinical diagnosis and treatment. Methods A total of 206 schistosomiasis patients including the acute, chronic and advanced were classified by ultrasonic evidences, and serological indicators of liver fibrosis were detected. The correlation among them was analyzed statistically. Results Ultrasonic diagnosis was 0 scale for acute group and control group, and Ⅱscale for chronic group, as well as Ⅲ scale for advanced group. Advanced group had the highest level of 4 serum indicators of liver fibrosis, and chronic group ranked the middle level, and acute group had the lowest level. The more advanced the ultrasonic scales of liver fibrosis, the higher level the 4 serum indicators. Conclusions There is a consistency relationship between ultrasonic classifications of liver fibrosis and serological indicators in schistosomiasis patients. It also conforms to clinical diagnosis. When ultrasound is applied in schistosomiasis, serological detection is essential and it could make up for the shortage of ultrasonic findings and give better guidance for clinical diagnosis and treatment.

Objective To explore the reliability and validity of the Chinese version of the Test of Everyday Attention (TEA) in normal Chinese people. Methods 117 normal volunteers (18～65 years old) were screened with the Montreal Cognition Assessment (MoCA), and the normal volunteers were administered to TEA (versions A), Trail Making Test B (TMT-B), Paced Auditory Serial Addition Task (PASAT), Stroop Color-Word Interference Test (SCWT), Continuous Performance Test (CPT). 20 normal volunteers were also given version B for testing of the test-retest reliability, time interval was 2 weeks between versions A and B. Results There was correlation between versions A and B in the major subtests (r>0.700, P<0.01) at a two-week interval. The varimax rotation principal-component analysis extracted 4 component factors, namely sustained attention, se lective attention, switching attention, and divided attention. The factors included various subtests of TEA and the other laboratory attentional test. Conclusion TEA has good reliability and validity.

This review summarized the important theory of attention and summed the attention assessment Methods and applications during the recent 50 years. In the future the field of neurological rehabilitation research in attention and attention assessment had been discussed.

Objective To test the impact of age, education and gender on the Chinese Version of the Test of Everyday Attention (TEA).Methods 117 normal volunteers were selected. They were grouped by age and education. After screening of Montreal Cognitive Assessment (MoCA), the volunteers were administered to the TEA (version A). Correlation analysis was performed between age and education with TEA. Comparisons between groups were tested in gender. Results There were significant correlations between most subtests with age except elevator counting, visual elevator counting (VE1) and lottery task. Education correlated with map search and elevator counting with reversal in the youth group. There were correlation between visual elevator (VE2) and telephone search while counting with education in the young and middle-aged group. Education related to map search, visual elevator (VE1, VE2), elevator counting with reversal, and telephone search in the middle-aged group. The subtests were not statistically different between different gender groups except telephone search. Conclusion Age and education had effect on TEA while Gender had no significant effect.

NK/T cell lymphoma is a distinct clinicopathologic entity which is more prevalent in Asia than in America and Europe and is highly associated with Epstein-Barr virus (EBV) infection. Although the clinicopathologic features of the tumor have been clearly defined, genetic changes and roles of virus associated with the development and progression of tumor have not been well studied. In this study, we carried out polymerase chain reaction (PCR) for EBNA-3B, EBNA-3C, and LMP-1 30 bp deletion to investigate EBV subtype and variants in tumor tissue and performed comparative genomic hybridization (CGH) to screen chromosomal imbalances using frozen tissues from 7 patients with nasal-type NK/T cell lymphoma and 1 patient with blastic NK cell lymphoma. Of 6 cases infected with EBV, there were EBV type 1 in six, LMP-1 30 bp deletion variant in four, and LMP-1 40 bp deletion variant in one. Frequent chromosomal imbalances included deletions at 1p31-pter (4), 12q23-q24 (3), and 17p (4), and gains at 2q (5), 10q (3), and 13q34-qter (4). Blastic NK cell lymphoma displayed deletions of 9q, 7q, and 6q, similar to that of nasal-type NK/T-cell lymphoma. With these results, we assumed that candidate genes in these imbalanced chromosomal loci would provide the clue for further molecular studies to identify putative tumor suppressor genes or proto-oncogenes associated with pathogenesis of this neoplasm.
Americas ; Asia ; Comparative Genomic Hybridization* ; Europe ; Genes, Tumor Suppressor ; Genotype* ; Herpesvirus 4, Human* ; Humans ; Killer Cells, Natural ; Lymphoma* ; Polymerase Chain Reaction ; Proto-Oncogenes

Objective To evaluate the value of Video-EEG for the diagnosis of children's non-epileptic seizures (NES). Methods A retrospective analysis was conducted in 105 cases of children with NES, which were diagnosed by 1 to 4 hours' video-EEG surveillance. Risk factors that interfered with the diagnosis were discussed. Results There were 91 cases (87%) of physiological NES and 14 cases (13%) of psychological NES among the total 105 NES. Misdiagnoses were made in 11 of 43 cases who received common EEG examination before. Conclusion Video-EEG was a reliable method to confirm the clinical diagnosis of non-epileptic seizures and differentiate it from epilepsy. EEG abnormality during seizure-free periods was the main risk factor for the misdiagnosis of NES.

Objective To evaluate the effects of indigenous staplers on anus-preservation,and postoperative target chemotherapy to prevent local recurrence and distant metastasis of low-situated rectal cancer.Methods 284 patients with low-situated rectal cancer hospitalized during Jan.1990 to Dec.2004 in the Second Affiliated Hospital of PLA General Hospital were treated surgically with indigenous staplers for anus-preservation,interoperative implantation of iliac artery pump and postoperative target infusion chemotherapy.They were followed up for 2~8 years.The clinical data including the result of anus-preservation,local recurrence rate,distant metastasis rate and long-term survival rate were retrospectively analyzed.Results All the 284 patients received anus-preservation operation with successful result.Among them 282 cases(99.3%) undervent the operation once,and the remaining two(0.7%) were operated on twice with success.Control of defecation was good in 247 cases(87.0%),anastomotic fistula occurred in 2 cases(0.7%),stanosis of anastomosis occurred in 1 case(0.4%),and bleeding from anastomotic site occurred in 1 case(0.4%).The follow-up data were completely collected from 236 cases(83.1%).The 1-,3-,5-year local recurrence was found in 2 cases(0.8%),6 cases(2.5%) and 8 cases(3.2%),respectively.The 1-,3-,5-year distant metastasis was found in 11 cases(4.7%),22 cases(9.3%) and 10 cases(4.3%),respectively.The 1-,3-,5-year overall survival rate were 97.0%(229/236),86.0%(203/236) and 65.3%(154/236),respectively.Conclusion The use of indigenous staplers is safe and dependable in operation for anus-preservation in low-situated rectal cancer.Postoperative target chemotherapy may decrease the local recurrence rate and distant metastasis rate,and raise the long-term survival rate as well.

Objective To investigate the expressions of EphB4 receptor and hypoxia inducible factor 1? (HIF-1?) protein in human primary gastric carcinoma, and to study the biological implication of their expression. Methods The expressions of EphB4 receptor and HIF-1? protein were detected in 74 specimens of human primary gastric carcinoma (gastric carcinoma group) and in 13 normal gastric mucosa tissues (control group) by immunohistochemistry. Correlations between the expression of these proteins, and clinical and pathological features were respectively analyzed. Result High expressions of EphB4 receptor and HIF-1? protein were found to be 62.2% (46/74) and 52.7% (39/74) respectively in gastric carcinoma group, while the expressions of EphB4 receptor and HIF-1? protein in control group were 15.38% (2/13) and 0% (0/13), respectively. The differences were significant between two grrups (P

Objective To investigate the efficacy and adverse effects of methotrexate(MTX) and Bacille Calmette Guerin-polysaccharide nucleic acid(BCG-PSN) in the treatment of steroid dependent asthma.Methods Sixty-eight patients with steroid dependent asthma were divided into therapy group and control group.The patients in therapy group were treated with MTX and BCG-PSN,while the control group was given only MTX.The dose of oral steroid daily,symptom scores,peak flow rates(PEF) and expiratory volume in one second(FEV1) were monitored.Results Compared with before treatment,daily steroid dosage and symptom scores of two groups significantly decreased(P0.05),while PEF and FEV1 significantly increased in therapy group(P0.05).Conclusion The combined use of MTX and BCG-PSN may be more beneficial than the single use of MTX for the treatment of steroid-dependent asthma.

Objective To measure the burden of chronic obstructive pulmonary disease (COPD) in a rural area of Kunming. Methods Shilin County was selected as the study region. Disability adjusted life years (DALY) was used to measure the burden to COPD. Results The overall prevalence of COPD was 6.68% , and males had higher prevalence of COPD than females. Females accounted for higher YLL rate and DALY rate due to COPD than males, whereas males had higher YLD rate due to COPD than females. People aged 60 years and over were responsible for higher YLL rate, YLD rate and DALY rate due to COPD compared to other age group. Conclusion COPD does harm to males' quality of life whereas threatens females' death in the study region. The region should focus on further prevention and control of COPD.