Objective To explore the relationship between the liver fibrosis scales of B-ultrasound and the serological indicators of schistosomiasis liver fibrosis for guiding clinical diagnosis and treatment. Methods A total of 206 schistosomiasis patients including the acute, chronic and advanced were classified by ultrasonic evidences, and serological indicators of liver fibrosis were detected. The correlation among them was analyzed statistically. Results Ultrasonic diagnosis was 0 scale for acute group and control group, and Ⅱscale for chronic group, as well as Ⅲ scale for advanced group. Advanced group had the highest level of 4 serum indicators of liver fibrosis, and chronic group ranked the middle level, and acute group had the lowest level. The more advanced the ultrasonic scales of liver fibrosis, the higher level the 4 serum indicators. Conclusions There is a consistency relationship between ultrasonic classifications of liver fibrosis and serological indicators in schistosomiasis patients. It also conforms to clinical diagnosis. When ultrasound is applied in schistosomiasis, serological detection is essential and it could make up for the shortage of ultrasonic findings and give better guidance for clinical diagnosis and treatment.

Objective To test the impact of age, education and gender on the Chinese Version of the Test of Everyday Attention (TEA).Methods 117 normal volunteers were selected. They were grouped by age and education. After screening of Montreal Cognitive Assessment (MoCA), the volunteers were administered to the TEA (version A). Correlation analysis was performed between age and education with TEA. Comparisons between groups were tested in gender. Results There were significant correlations between most subtests with age except elevator counting, visual elevator counting (VE1) and lottery task. Education correlated with map search and elevator counting with reversal in the youth group. There were correlation between visual elevator (VE2) and telephone search while counting with education in the young and middle-aged group. Education related to map search, visual elevator (VE1, VE2), elevator counting with reversal, and telephone search in the middle-aged group. The subtests were not statistically different between different gender groups except telephone search. Conclusion Age and education had effect on TEA while Gender had no significant effect.

This review summarized the important theory of attention and summed the attention assessment Methods and applications during the recent 50 years. In the future the field of neurological rehabilitation research in attention and attention assessment had been discussed.

Objective To explore the reliability and validity of the Chinese version of the Test of Everyday Attention (TEA) in normal Chinese people. Methods 117 normal volunteers (18～65 years old) were screened with the Montreal Cognition Assessment (MoCA), and the normal volunteers were administered to TEA (versions A), Trail Making Test B (TMT-B), Paced Auditory Serial Addition Task (PASAT), Stroop Color-Word Interference Test (SCWT), Continuous Performance Test (CPT). 20 normal volunteers were also given version B for testing of the test-retest reliability, time interval was 2 weeks between versions A and B. Results There was correlation between versions A and B in the major subtests (r>0.700, P<0.01) at a two-week interval. The varimax rotation principal-component analysis extracted 4 component factors, namely sustained attention, se lective attention, switching attention, and divided attention. The factors included various subtests of TEA and the other laboratory attentional test. Conclusion TEA has good reliability and validity.

NK/T cell lymphoma is a distinct clinicopathologic entity which is more prevalent in Asia than in America and Europe and is highly associated with Epstein-Barr virus (EBV) infection. Although the clinicopathologic features of the tumor have been clearly defined, genetic changes and roles of virus associated with the development and progression of tumor have not been well studied. In this study, we carried out polymerase chain reaction (PCR) for EBNA-3B, EBNA-3C, and LMP-1 30 bp deletion to investigate EBV subtype and variants in tumor tissue and performed comparative genomic hybridization (CGH) to screen chromosomal imbalances using frozen tissues from 7 patients with nasal-type NK/T cell lymphoma and 1 patient with blastic NK cell lymphoma. Of 6 cases infected with EBV, there were EBV type 1 in six, LMP-1 30 bp deletion variant in four, and LMP-1 40 bp deletion variant in one. Frequent chromosomal imbalances included deletions at 1p31-pter (4), 12q23-q24 (3), and 17p (4), and gains at 2q (5), 10q (3), and 13q34-qter (4). Blastic NK cell lymphoma displayed deletions of 9q, 7q, and 6q, similar to that of nasal-type NK/T-cell lymphoma. With these results, we assumed that candidate genes in these imbalanced chromosomal loci would provide the clue for further molecular studies to identify putative tumor suppressor genes or proto-oncogenes associated with pathogenesis of this neoplasm.
Americas ; Asia ; Comparative Genomic Hybridization* ; Europe ; Genes, Tumor Suppressor ; Genotype* ; Herpesvirus 4, Human* ; Humans ; Killer Cells, Natural ; Lymphoma* ; Polymerase Chain Reaction ; Proto-Oncogenes

Hypothyroidism is a common endocrine disease.Its treatment depends on thyroid hormone replacement therapy.Currently,levothyroxine (L-T4) is the preparation recommended by many guidelines.However,there are some L-T4-treated patients with normal TSH levels and persistent non-specific symptoms and discomforts.Therefore,combination therapy with L-T4and liothyronine (L-T3) has been considered as an alternative option for hypothyroidism.However,more prospective studies are needed to provide evidence-based effects for this kind of regimen.

Objectives To compare the differences in intestinal phylum firmicutes between elderly patients with type 2 diabetes (T2DM)and the healthy elder people.Methods 37 elderly patients with T2DM and 69 healthy controls in Shaoxin city were recruited.DNA of phylum firmicutes from fecal samples was extracted.The real-time quantitative PCR was used with special primers for bacterial genus including Faecalibacterium prausnitzii,Eubacterium rectale,Clostridium leptum,and Peptostrepyococc.The differences in content of different bacteria between two groups were analyzed and compared.Results In healthy elderly group versus the elder patient with T2DM,the contents of intestinal phylum firmicutes were[(6.22±1.41) × 107 versus(5.41± 1.40) × 107,t=2.83,P=0.006] in Eubacterium rectale,[(7.46 ± 0.98) × 107 versus (6.96 ± 1.40) × 107),t =2.13,P =0.036] in Faecali bacterium prausnitzii,[(7.89±0.89) × 107 versus(7.46±1.11) × 107,t=2.15,P=0.034]in Clostridium leptum,and[(4.86 ± 1.33) × 107 versus (4.21 ± 1.24) × 107,t=2.45,P =0.016] in Peptostrepyococc,which showed that the contents of intestinal phylum firmicutes were less in T2DM group than in healthy elderly group.Conclusions There are some differences in intestinal flora between the elderly patients with T2DM and healthy people.These intestinal flora may play an important role in the development of T2DM.This study may provide new evidences for probiotic treatment of T2DM.

Dental Clinics ; Emergency Treatment ; Humans ; Hypersensitivity

Dental Care ; Dental Clinics ; Emergencies ; Humans

Objective To measure the burden of chronic obstructive pulmonary disease (COPD) in a rural area of Kunming. Methods Shilin County was selected as the study region. Disability adjusted life years (DALY) was used to measure the burden to COPD. Results The overall prevalence of COPD was 6.68% , and males had higher prevalence of COPD than females. Females accounted for higher YLL rate and DALY rate due to COPD than males, whereas males had higher YLD rate due to COPD than females. People aged 60 years and over were responsible for higher YLL rate, YLD rate and DALY rate due to COPD compared to other age group. Conclusion COPD does harm to males' quality of life whereas threatens females' death in the study region. The region should focus on further prevention and control of COPD.