OBJECTIVE:To observe clinical efficacy and safety of thymosin in adjunctive treatment of chronic eczema,and to investigate its mechanism from the change of peripheral T lymphocyte subsets. METHODS:160 patients with chronic eczema were randomly divided into observation group and control group,with 80 cases in each group. Both group received conventional therapy as mizolastine,Desonide cream. Observation group additionally received Thymosin enteric-coated tablet 20 mg,po,tid;control group was given placebo the appearance of which was same with Thymosin enteric-coated tablet. Treatment course lasted for 4 weeks. The change of T lymphocyte subsets,clinical efficacy and the occurrence of ADR were compared between 2 groups. Re-currence rate of both groups were followed up for 1 year. RESULTS:The effective rate of observation group(91.25%)was signifi-cantly higher than that of control group(77.50%),with statistical significance(P<0.05). After treatment,CD4+ and CD4+/ CD8+ of 2 groups were significantly increased,while CD8+ was decreased significantly;CD4+ and CD4+/ CD8+ of observation group were significantly higher than those of control group,with statistical significance(P<0.05),but there was no statistical significance in CD8+ between 2 groups(P>0.05). There was no statistical significance in the incidence of ADR between 2 groups(P>0.05). Re-currence rate of observation group(31.51%)was significantly lower than that of control group(64.52%)during follow-up period, with statistical significance (P<0.05). CONCLUSIONS:In summary,thymosin can improve clinical efficacy and reduce recur-rence rate by regulating T lymphocyte subsets with good safety.

Rehabilitation and related professions have grown rapidly in China during this decade. Quality of life becomes a top priority after acute care service has been delivered. Communication is a unique and essential skill of humans and is one of the main factors influencing quality of life. People share their ideas with each other and advocate for their rights by communicating. The purpose of this paper is to introduce the general concepts of Augmentative and Alternative Communication (AAC). The paper includes a brief explanation of AAC, types of AAC, targeted populations benefitted by AAC, principles of a language-based service delivery, and a discussion of interdisciplinary team member roles.>Rehabilitation and related professions have grown rapidly in China during this decade. Quality of life becomes a top priority >after acute care service has been delivered. Communication is a unique and essential skill of humans and is one of the main factors influencing >quality of life. People share their ideas with each other and advocate for their rights by communicating. The purpose of this paper is to introduce>the general concepts of Augmentative and Alternative Communication (AAC). The paper includes a brief explanation of AAC, types>of AAC, targeted populations benefitted by AAC, principles of a language-based service delivery, and a discussion of interdisciplinary team>member roles

An augmentative and alternative communication (AAC) assessment is a complex, multidisciplinary process. Historic AAC assessment models have focused on treatment providing for basic communication needs more than on consideration of optimizing communication and maximizing an individual's potential. This paper presents an AAC assessment model based on the goal of interactive communication and a comprehensive evaluation of cognitive, linguistic, sensory and motor abilities that is evidence-based. We describe each component and assessment step within an evidence-based framework. The purpose is to offer a systematic, principled approach to selecting AAC assessment procedures in rehabilitation, speech language pathology and other related fields in order to strengthen their confidence in providing best possible services to clients who require AAC.

Objective The research is about optimization of preparation procedure of self-microemulsifying dropping pills of paclitaxel (PTX-SM-DP) .The drug release in vitro of PTX-SM-DP was investigated .Methods The ratio of SMEDDS and bases ,dropping distance ,temperature and speed of dripping were investigated by using the orthogonal test .The weight differ-ence of dropping pill ,hardness and roundness were evaluated to optimize the preparation conditions of PTX-SM-DP .Dissolu-tion of vitro was determined .Results The optimal preparation conditions were as follows :the ratio of SMEDDS and bases was 1∶3 ,dropping distance was 15 cm ,temperature of dripping preparation was 80 ℃ and dripping speed was 30 drops/min . Conclusion The optimized technical condition is stable and feasible .PTX-SM-DP can improve paclitaxel dissolution .

Catharanthine content and agronomic traits in major Catharanthus roseus varieties were analyzed. It was found that there existed great difference in catharanthine content and agronomic traits among the varieties. Catharanthine content was the highest in variety Pacifica Polka Dot (PPD), reaching 3.79 mg g(-1) dry leaf weight, and the lowest in variety Cooler Pink (CP) with only 0.9 mg g(-1) dry leaf weight. Correlation existed in certain extent between catharanthine content and agronomic traits in C. roseus. Path analysis showed that among all the agronomic traits analyzed, internodal distance positively affected catharanthine content at significant level (P<0.05), with the path coefficient being 1.473. This study provides useful information for high-catharanthine content C. roseus introduction and breeding.
Catharanthus ; anatomy & histology ; chemistry ; metabolism ; Plant Leaves ; anatomy & histology ; chemistry ; metabolism ; Vinca Alkaloids ; analysis ; metabolism

Objective:To explore the characteristics of intestinal flora in children with asthma from the theory of "lung and large intestine being interior-exterior" , and to provide an experimental basis for the study of "lung and intestine axis" .Methods:Based on 16S rDNA high-throughput sequencing technology, stool samples from children with 30 asthma and 28 healthy children were enrolloed and sequenced. All patients are from january 2018 to April 2018, Shanghai Children's Medical Center affiliated to Shanghai Jiaotong University Medical College and Oriental Hospital Affiliated to Tongji University. Statistical methods such as Principal component analysis (PCA), LEfSe analysis, linear discriminant analysis (LDA), and non-metric multidimensional scale analysis (NMDS) were used to analyze intestinal flora characteristics of asthma children.Results:The number of Intestinal flora operating taxon unit (OTU) in asthmatic group (141.96 ± 27.42 vs. 164.54 ± 50.58, P=0.048), Shannon index (2.49 ± 0.51 vs. 2.80 ± 0.56, P=0.044) were significantly lower than those of healthy children group, and Simpson index (0.18 ± 0.06 vs. 0.13 ± 0.07, P=0.010) was significantly higher than that of healthy children. There was no significant difference in intestinal flora abundance between asthmatic children and healthy children ( P>0.05), but there was a decreasing trend. Further differential intestinal flora analysis showed that there were differences in bacterial abundance between children with asthma and healthy children. Conclusion:Children with asthma showed high related with intestinal flora disorders, referring that asthma maybe treated when intestinal flora is treated, which provides a reference for the study of the relationship between lung and intestine from the perspective of intestinal flora.

Primary ciliary dyskinesia（PCD）is a genetic disease characterized by abnormal ciliary structure and function，with respiratory symptoms being the main clinical manifestation of PCD.The pathogenesis behind PCD is that gene variants cause structural or functional disorders of respiratory cilia and motile cilia of other organs，leading to a series of heterogeneous clinical manifestations，which makes it difficult to identify and diagnose PCD.Combining different disease screening tools and understanding the relationship between genotypes and phenotypes may facilitate early diagnosis and treatment for PCD.

OBJECTIVETo evaluate the effect of individualized scalp acupuncture base on location of brain function for motor dysfunction in stroke patients.

METHODSA total of 180 patients were randomly assigned into an individualized scalp acupuncture (ISA) group, a conventional scalp acupuncture (CSA) group and a rehabilitation group, 60 cases in each one. In the ISA group, we stimulated Sishencong (EX-HN 1), motor area and balance area, matched with pre-motor area for higher muscle tension, application area and's three-needle for involuntary motion, application area for poor motor coordination, forehead five-needle for cognitive disorder, sensory area for sensory disturbance. In the CSA group, the affected Dingnieqianxiexian (MS 6), Dingniehouxiexian (MS 7) and Zhenxiapangxian (MS 14) were selected. Rehabilitation was used during needle retained in the two groups. Simple rehabilitation was used in the rehabilitation group. All the treatment was given from Monday to Friday for 4 weeks, once a day for 20 times. Eight-week follow-up was applied. The Fugl-Meyer assessment (FMA) for motor function, modified Barthel Index (MBI) were used to evaluate clinical effect.

RESULTSAfter treatment and at follow-up, FMA and MBI scores increased compared with those before treatment in the three groups（all<0.01）, with significant differences among the three groups (all<0.000 1) and better results in the ISA group compared with those in the other two groups (<0.05,<0.01) at the two time points. The FMA and MBI scores in the CSA group were higher than those in the rehabilitation group after treatment and at follow-up (all<0.05).

CONCLUSIONThe individualized scalp acupuncture can improve motor dysfunction and self-care ability of daily life for stroke patients.