1.The R-Stereoisomer of Ketamine as an Alternative for Ketamine for Treatment-resistant Major Depression.
Clinical Psychopharmacology and Neuroscience 2014;12(1):72-73
No abstract available.
Depression*
;
Ketamine*
3.Ketamine with Propofol for Endoscopic Procedures.
Korean Journal of Anesthesiology 2018;71(4):334-335
4.The use of ketamine for perioperative pain management.
Korean Journal of Anesthesiology 2012;63(1):1-2
No abstract available.
Ketamine
;
Pain Management
5.The Effect of Ketamine for Pain on Rocuronium Injection Pain.
Hae Wone CHANG ; Seung Ryong KIM ; Yoon Ki LEE
Korean Journal of Anesthesiology 2005;48(5):479-482
BACKGROUND: Rocuronium can cause pain on injection in awake patients. We compared the effect of ketamine at three different small doses (0.1 mg/kg, 0.2 mg/kg, 0.3 mg/kg) and saline (placebo) for reducing pain on injection in awake patients. METHODS: 80 patients (aged 19-63 yr) scheduled for elective surgery were randomized to four groups in double-blind manner. Patients received the study drug intravenously, with venous occlusion for 20 seconds, followed by rocuronium 0.6 mg/kg into the dorsal vein over 10 seconds. Patient's response torocuronium injection was graded by four-point verbal rating scale. RESULTS: The incidence of pain was significantly less in patients receiving ketamine 0.3 mg/kg (55%) than in patients receiving saline (85%)(P < 0.05). But, No difference was found between ketamine 0.1 mg/kg, 0.2 mg/kg and saline groups. The pain score was significantly less in patients receiving ketamine 0.2 mg/kg and 0.3 mg/kg than in patients receving saline (P < 0.05). CONCLUSIONS: We concluded that pretreatment of ketamine 0.3 mg/kg with venous occlu-sion for 20 seconds, effectively decreases the incidence of pain caused by rocuronium injection.
Humans
;
Incidence
;
Ketamine*
;
Veins
6.Mammalian Target of Rapamycin Signaling Pathways and Depression.
Jung Goo LEE ; Mi Kyong SEO ; Sung Woo PARK ; Young Hoon KIM
Journal of the Korean Society of Biological Psychiatry 2016;23(1):18-23
Depression is a complicated psychiatric illness with severe consequences. Despite recent advanced achievements of molecular neurobiology, pathophysiology of depression has not been well elucidated. Among new findings of pathophysiology of depression, the possible fast antidepressant effect by N-methyl-D-asparate receptor antagonist, such as ketamine, is regarded as a promising treatment target of depression. Ketamine stimulates the mammalian target of rapamycin (mTOR) signaling pathway and activation of mTOR signaling pathway may be a key mechanism of the antidepressant effect of ketamine. Thus, this review describes the role of mTOR signaling in the pathophysiology of depression and developing a new treatment target of depression.
Depression*
;
Ketamine
;
Neurobiology
;
Sirolimus*
7.Efficacy of intranasal dexmedetomidine in combination with ketamine as premedication and sedation in pediatric patients: A systematic review and meta-analysis
Cristina Marides L. Quijano ; Kryzia June B. Balneg
The Philippine Children’s Medical Center Journal 2024;20(1):84-102
Objective:
To compare the efficacy and safety of the combination of Dexmedetomidine (Dex)
and Ketamine (Ket) administered via the intranasal (IN) route on sedation of children aged 0 to 12
years old prior to elective surgery or procedural sedation as compared to Intranasal
Dexmedetomidine.
Methods:
Relevant studies were identified after a literature search on electronic databases as
PubMed, Cochrane Library, Google Scholar and Science Direct. Meta-analyses of mean differences
were performed to examine differences in sedation onset and recovery times between IN Dex-Ket
and IN Dex. Meta-analyses of proportions were performed to estimate the incidence of sedation
success, satisfactory sedation at parental separation and mask induction, and incidence of adverse
events. Review Manager 5.4.1 was used for statistical analysis.
Results:
Six articles (388 patients) were included. The overall incidence of sedation success was
higher among children premedicated with IN Dex-Ket (RR = 1.05; 95%CI = 0.97,1.13; P = 0.27, I2
= 20%) however was not statistically significant. Children given IN Dex-Ket had faster sedation
onset time (WMD = -7.17; 95%CI = -12.44, -1.89; P=0.008) with greater incidence of satisfactory
sedation at mask induction (RR = 0.71; 95%CI = 0.53, 0.94; P = 0.02). There was no significant
difference as to recovery time and incidence of adverse events among the groups.
Conclusion
Premedication with IN Dex-Ket is as safe as IN Dex but of better efficacy as
evidenced by faster sedation onset time and smoother inhalational induction without increasing
clinically relevant adverse events.
Dexmedetomidine
;
Ketamine
;
Premedication
8.Urodynamic Studies in Ketamine-Anesthetized Children.
Jin Seon CHO ; Snag Yol MAH ; Seung Kang CHOI
Korean Journal of Urology 1988;29(5):731-734
Urodynamic studies were done on 11 children with voiding problems and 10 children without voiding problems. The evaluations were performed with 13 children under ketamine anesthesia because testings without anesthesia had proved unsatisfactory. With cooperation of 8 children the evaluations were performed without anesthesia. Detrusor contractions occurred in 10 of 13 children under anesthesia and sufficient data were obtained to identify accurate patterns of voiding dysfunction. A method for anesthetic neurourolgic study using ketamine is presented, which permits reliable urodynamic observations on the swakening patients in whom investigations are incomplete or unsatisfactory.
Anesthesia
;
Child*
;
Humans
;
Ketamine
;
Urodynamics*
9.Urodynamic Studies in Ketamine-Anesthetized Children.
Jin Seon CHO ; Snag Yol MAH ; Seung Kang CHOI
Korean Journal of Urology 1988;29(5):731-734
Urodynamic studies were done on 11 children with voiding problems and 10 children without voiding problems. The evaluations were performed with 13 children under ketamine anesthesia because testings without anesthesia had proved unsatisfactory. With cooperation of 8 children the evaluations were performed without anesthesia. Detrusor contractions occurred in 10 of 13 children under anesthesia and sufficient data were obtained to identify accurate patterns of voiding dysfunction. A method for anesthetic neurourolgic study using ketamine is presented, which permits reliable urodynamic observations on the swakening patients in whom investigations are incomplete or unsatisfactory.
Anesthesia
;
Child*
;
Humans
;
Ketamine
;
Urodynamics*
10.Comparison of dexmedetomidine and ketamine for the analgesic effect using intravenous patient-controlled analgesia after gynecological abdominal surgery.
Wonjin LEE ; Jung Dae SHIN ; Kwangrae CHOE ; Myoung Hun KIM
Korean Journal of Anesthesiology 2013;65(6 Suppl):S132-S134
No abstract available.
Analgesia, Patient-Controlled*
;
Dexmedetomidine*
;
Ketamine*