1.A study of the burden of disease and accurate health poverty alleviation policy in poor chronic diseases in China
Chinese Journal of Health Policy 2017;10(6):64-67
The study explores the current situation of the burden of chronic poor patients and the core essence of the accurate health poverty alleviation policy.More specifically, it aims to analyze the existing problems and practical dilemmas in the implementation of the accurate health poverty alleviation policy, and conveying recommendations for the policy formulation.The analysis shows that the problems in the implementation of the accurate health poverty alleviation policy in China are: the empowerment of the poor population is not accurate;the dynamic management and assessment mechanism is not accurate;and the allocation of poverty alleviation resources is not rational.In view of these problems, the following suggestions were put forward: the establishment of a multi-dimensional poverty identification system, the improvement of poor households through building up their card information;improve the accurate poverty alleviation dynamic supervision and assessment system;rational allocation of poverty alleviation resources, promote the supporting policies and institutional innovation.
2.Clinical and histopathological alterations of lymphangioleiomyomatosis in 14 Chinese patients.
Shao-hua LU ; Ying-yong HOU ; Yun-shan TAN ; Jian-fang XU ; Hai-ying ZENG ; A-kesu SUJIE ; Xiang-dong WANG ; Chun-xue BAI
Chinese Medical Journal 2009;122(16):1895-1900
BACKGROUNDLymphangioleiomyomatosis (LAM) is a rare disease that predominantly affects young females. It is considered as an "orphan" life-threatening disease of unknown etiology, with uncertain clinical prognosis, and no effective treatment. LAM can arise sporadically or in association with tuberous sclerosis complex (TSC), an autosomal inherited syndrome characterized by hamartoma-like tumor growth and pathologic features that are distinct from manifestations of pulmonary LAM. The clinical course of LAM is characterized by progressive dyspnea on exertion, recurrent pneumothorax, and chylous fluid collections.
METHODSFourteen cases of LAM from Zhongshan Hospital, Fudan University are reviewed, twelve were confirmed by lung biopsy, one by retroperitoneal lymphangioleiomyoma resection, and one by autopsy.
RESULTSAll 14 patients were women, aged 18 to 69 years (mean 43.3 years, median 46.5 years). Haemoptysis (57.1%) and chylothorax (35.7%) were more frequent than those described in previous case series. Extrapulmonary findings such as renal angiomyolipoma (AML), enlarged abdominal lymph nodes, liver AML and retroperitoneal lymphangioleiomyoma were seen in 21.4%, 14.3%, 7.14% and 7.14% in 14 cases respectively, which is remarkably lower than in the previously reported. Abnormal smooth muscle cells (LAM cells) were found to line the airways, bronchioles, lymphatics and blood vessels leading to airflow obstruction and replacement of the lung parenchyma by cysts. There were some surprises in the autopsy case as several LAM cell emboli were found in the veins of mediastinum lymph nodes; LAM cells were found to be disseminated in soft tissues adjacent to the ilium.
CONCLUSIONSWomen with unexplained recurrent pneumothorax, tuberous sclerosis, or a diagnosis of primary spontaneous pneumothorax or emphysema in the setting of limited or absent tobacco use should undergo high-resolution computed tomography (HRCT) scan screening for LAM. Routine abdominal and pelvic imaging examinations should be performed to detect extrapulmonary involvement. The autopsy studies histologically suggested that LAM could be a multisystemic disease and LAM cells might possess metastatic potential.
Adolescent ; Adult ; Aged ; Contraceptives, Oral, Synthetic ; Female ; Humans ; Immunohistochemistry ; Lymphangioleiomyomatosis ; diagnosis ; drug therapy ; metabolism ; pathology ; surgery ; Medroxyprogesterone ; therapeutic use ; Middle Aged ; Ovariectomy ; Progesterone ; therapeutic use ; Progestins ; therapeutic use ; Young Adult