Objective: To evaluate the the effect of two blood purification in patients with chronic renal failure uremia. Methods: One hundred cases of patients from April 2012 to February 2014 in our hospital were chosen as the experimental object, and were divided into experimental group and control group, control group were treated with hemodiafiltration, and the experimental group were treated with high-flux hemodialysis,the serum medium and small molecule toxins and cognitive function improvement were compared. Results:The serum medium and small molecule toxins and cognitive function of two group were greatly improved, there were significant differences(t=4.113, t=0.430, t=1.038, t=0.346; P<0.05).The experimental group after treatment, serum phosphorus, parathyroid hormone was lower than the control group, the difference was statistically significant (t=-4.189, t=4.113;P<0.05). The experimental group PL and Amp were better than the patients in the control group, the difference was statistically significant (t=15.023, t=3.428; P<0.05). Conclusion: Two blood purification has good effect on treating patients with chronic renal failure uremia, but the improving effect of high flux hemodialysis scavenging effect on cysC, parathyroid hormone and serum phosphorus and cognitive function are better than that of hemodiafiltration.

Objective:To report and analyze a rare family of sponduloepiphyseal dysplasia congenital(SEDC) in order to supply more resources for genetic bone disease. Methods:Investigation and analysis was performed on a four generation's family of SEDC.Clinic characteristics including X-ray image and chromosome analysis were evaluated.Results:Nine persons suffered from SEDC in this four(generation's) family.The patients presented with same clinical characteristics.The main bone damages affected vertebrae,articulatio coxae,caput femoris and neck. Conclusion:The mode of inheritance of SEDC may be autosomal dominant inheritance.Gene defect during embryonic period may interfere the growth of osteoepiphysis.Further molecular pathologic studies were needed to find the evidence of genetic prognostication of SEDC.