Objective To explore the effect of cognitive behavior intervention on anxiety and depression of patients with acute myocardial infarction(AMI).Methods Seventy patients with acute myocardial infarction were randomly divided into observation group and control group,35 cases in each group. All cases were cared with routine nursing method. Besides,cognitive behavior intervention was applied in the observation group. The self-rating anxiety scale(SAS)and self-rating depression scale(SDS)were used to measure the patients' mental status before and after the intervention.Result The SAS and SDS scores of the observation group after intervention were significantly lower than those of the control group(P<0.05).Conclusion The cognitive behavioral intervention is effective in alleviating anxiety and depression in patients with acute myocardial infarction,promoting them to establish the correct attitude and keeping calm in face of disease so as to relieve the anxiety and depression of AMI patients.