To evaluate the renal function after cardiopulmonary bypass (CPB) and the effect of Urinastatin on renal function, the tubular and glomerular damage were studied in patients underwent cardiac operations, dividing following two groups; Group U with Urinastain and Group C without Urinastatin. Of indexes of glomerular function, changes in serum creatinine and urine nitrogen, and creatinine clearance did not show remarkably after CPB. Serum β₂-microglobulin indicating glomerular function after CPB demonstrated significantly higher levels than that before operation in Group C, but did not in Group U. N-acetyl-β3-D-glucosaminidase and γ-glutamyl-transpeptidase in urine as markers of tubular function rose significantly after CPB in both groups, but they showed significantly lower level in Group U than in Group C. After CPB, even in patients without clinical renal failure, glomerular and tubular dysfunction were placed. Urinastatin was considered to be effective in protection of glomerular and tubular function.

Median sternotomy is the most common approach used for repeated cardiac surgery, but it is associated with potential risks such as cardiac injury. Patients with valvular heart disease may be especially prone to these complications because of severe cardiomegaly and adherence of the heart to the posterior sternum. To avoid these risks, we began using a right thoracotomy approach, performed through a right parasternal vertical incision, which is better than the traditional right anterolateral thoracotomy, in selected patients. A 50-year-old woman who had undergone 3 previous cardiac operations at another hospital presented with remarkable cardiomegaly. We performed successful tricuspid valve replacement for tricuspid stenosis, through a right parasternal vertical incision. This approach provides excellent exposure of the tricuspid valve with minimal need for dissection. The right parasternal vertical incision has 3 main advantages over right anterolateral thoracotomy; first, it provides an excellent view of the right atrium underneath the wound; second, it allows for easy cannulation because of the position of the spine; and third, the skin incision is smaller. In conclusion, we think that the parasternal vertical incision is a better approach for repeated cardiac surgery than anterolateral thoracotomy because it provides a better operative view and an easier maneuver.

A case of a reflex sympathetic dystrophy syndrome (RSD) asscciated with the internal iliac arterio-venous fistula was reported. The patient was a 36-year old woman, and had the left oophorectomy at 21-year old and the lumbar laminectomy at 36-year-old. She complained of coldness and paresthesia of the right lower extremity 14 days after the lumbar laminectomy. A stenosis or occlusion of the arteries in both legs were not demonstrated by arteriogram. The coldness and paresthesia disappeard after the epi-dural block. RSD of the right leg was diagnosed which occurred at the lumbar laminectomy. Lumbar sympathectomy (L2∼L4) was performed simultaneously with closure of the internal iliac arteriovenous fistula. Postoperative clinical course was uneventful. Symptoms we were immediately disappeared. Sympathetic ganglion block has same efficiency as lumbar sympathectomy. Therefore sympathetic ganglion block is more suitable if patient has RSD only.

It is known that the prognosis of preductal type coarctation of the aorta is poor because cardiac malformation is frequent in these cases. There have been very few reports on adult cases of the coarctation. We have recently carried out aneurysmectomy and reconstructed the descending aorta by a 30mm Veri-Soft tube graft for one adult case of descending aortic aneurysm associated with coarctation of the aorta. The patient was 49-year-old female. Segmental stenosis 5cm in length was demonstrated in the thoracic descending aorta immediately below the bifurcation of the left subclavian artery. The poststenotic dilatation was shown at the distal portion of the segmental stenosis. The postoperative clinical course was uneventful.

Preoperative and operative evaluation of the arterial reconstructive tract is very important to obtain a high reconstructed graft patency rate after femoro-popliteal bypass. We analyzed the graft patency rate of 40 cases in which the graft flow was measured immediately after completion of arterial reconstruction. The mean graft flow was 122.6ml/min in patients with above-knee (AK) reconstruction and 57.4ml/min in those with below-knee (BK) reconstruction. In cases with AK reconstruction, the three-year cumulative patency rates of grafts with a blood flow of 120ml/min or more (n=12) or less than 120ml/min (n=11) were 100% and 80.8%, respectively (p<0.05). In cases with BK reconstruction, the three-year cumulative patency rates of grafts with a blood flow of 55ml/min or more (n=9) and less than 55ml/min (n=8) were 62.2% and 50.0%, respectively. All early occlusions (n=5) occurred in patients with BK reconstructions. Despite having a blood flow greater than 55ml/min, two cases became occluded in the early stage due to knee joint bending. It is considered that intraoperative measurement of the graft flow is one index to predict graft patency.

Quantitative histochemical analysis of the internal thoracic artery (ITA) and right gastroepiploic artery (GEA) was performed using microspectrophotometry. Arterial specimens from eight patients who underwent coronary bypass grafting using both ITA and GEA grafts were examined. There were seven men and one woman with a mean age of 60 years; ranging from 36 to 73 years. Concerning risk factors, 4 patients had hypertension, 3 had hypercholesterolemia and 2 had diabetes mellitus. The degree of intimal hyperplasia was calculated as follows; Intimal hyperplasia (%)=(I/I+M)×100 (I: area of intima, M: area of media). Quantitative histochemical analysis (smooth muscle cells, elastin, collagen and mucopolysaccaride) of arterial graft was measured by means of microspectrophotometry. Pieces of both the ITA and GEA grafts were obtained immediately before grafting. Each sample was stained with Azocarmin G, Weigert, van Gieson and Alcian Blue stains to identify smooth muscle cells, elastin, collagen and mucopolysaccaride, respectively. Intimal hyperplasia was significantly greater in GEA than ITA grafts (25.3 ±8.7% versus 6.8±3.5%, respectively; p<0.01). In quantitative histochemical analysis of the arterial grafts, the volume of smooth muscle cells was also significantly higher in GEA than ITA at both the intima (ITA; 38.8±7.9%E, GEA; 52.5±7.6%E, p<0.01) and media (ITA; 49.6±6. 5%E, GEA; 59.5±8.2%E, p<0.05). No significant differences in elastin, collagen or mucopolysaccaride content were observed. The greater amount of smooth muscle in GEA grafts may be one reason why the magnitude of intimal hyperplasia was greater in GEA than ITA grafts. Long-term follow-up is necessary to determine the course of atherosclerotic change in arterial grafts.

A chronic contained rupture of an infrarenal abdominal aortic aneurysm eroded a lumbar vertebra. A 53-year-old man complained of severe back pain for 6 months. Recently the back pain had increased. The patient looked well but a pulsatile mass in the abdomen was palpable. A CT and MRI of the abdomen and lumbar spine revealed the infrarenal abdominal aneurysm which demonstrated destruction of the third and fourth lumbar vertebra. At operation, there was a true aneurysm of the native aorta with a rupture of the posterior wall, resulting in a retroperitoneal hematoma. An orifice of the ruptured pseudoaneurysma was 2×2cm in size. An aortobiiliac graft was implanted. The patient did well postoperatively and was discharged on the 32nd postoperative day.

We used the Fogarty 2Fr IMAG Kit^® on 14 patients who underwent aorto-coronary bypass grafting. The free flow of the left internal thoracic artery (LITA) after dilatation using Fogarty balloon catheter was 7.4 times greater than before dilatation. There was no statistical differences in catecholamines used postoperatively and postoperative cardiac output in the groups of cases with and without dilatation. String sign was appeared in 4 patients with dilatation of LITA. Fogarty balloon catheter save effective dilatation of LITA in certain selected cases.

Aberrant right subclavian artery is a common congenital anomaly of the aortic arch, with a reported prevalence of approximately 0.5%. However aneurysms of this aberrant vessel are very rare. A 71-year-old man was admitted with cerebral hemorrhage. Chest X-ray revealed an abnormal upper mediastinal shadow. Angiography, computed tomography (CT) scan, and magnetic resonance (MR) imaging revealed an aberrant origin of the right subclavian artery arising as the fourth branch of the aortic arch and crossing the mediastinum from left to right indenting the esophagus posteriorly. The origin of the right subclavian artery was aneurysmal (maximum diameter was 5cm), and this aneurysm did not compress the esophagus. The patient was treated by Dacron patch graft aortoplasty and right subclavian artery reconstruction with the aid of cardiopulmonary bypass and hypothermic selective cerebral perfusion. The postoperative course was uneventful and there were no major complications. The surgical technique is detailed as well as a review of all the cases in the literature.

A total of 56 patients undergoing coronary artery bypass grafting were allocated to two groups: the Cold group (28 patients) with cold (4°C) crystalloid cardioplegia and topical ice slush, and the Tepid group (28 patients) with tepid (32°C) blood cardioplegia delivered intermittently antegrade. The two groups were comparable in terms of preoperative New York Heart Association classification, age, gender, and number of grafts. Intraoperatively, tepid blood cardioplegia was associated with a significantly shorter cardiopulmonary bypass time and nearly uniform return of normal sinus rhythm. Cardiac output after bypass was significantly higher than before bypass only in the Tepid group. The absolute peak levels in the myocardial-specific isoenzyme of creatine kinase were higher in the Cold group (70±8IU/l) than in the Tepid group (31±5IU/l). There was a trend toward reduced incidence of perioperative myocardial infarction (0% versus 7.1%) and need for intraaortic balloon pump support (0% versus 3.6%) associated with the use of tepid blood cardioplegia. Our results suggest that intermittent tepid blood cardioplegia is a safe and effective technique for coronary artery bypass grafting.