Records on every 6 hour symptom were kept for the period from July 15 through November 30, 1983 by 19, 19 and 26 patients who were outpatients at the Sapporo Civil Hospital, the University of Tokyo Hospital and the University of Ryukyu Hospital. Every 6 hour fluctuations in percentage of asthmatic symptoms were calculated from these records.
Meteorological conditions prevailing each city were classified into 9 patterns, i. e., west-high-east-low pattern, north-high pattern, south-high-north-low pattern, east-high-west-low pattern, ridge pattern, trough pattern (east-west), migratory anticyclone pattern, trough pattern (south-north) and tropical depression pattern.
An asthma frequency (AF)in days under a certain type of meteorological conditions was compared with that in all the other days. Asthmatic symptoms were more frequent in the days under west-high-east-low pattern and those under migratory anticyclone pattern were also higher. An AF in days under south-high-north-low pattern and that in days under trough pattern (east-west) were lower.
Most of days under west-high-east-low pattern were in late autumn in each of the 3 cities. The temperature of the days in Tokyo under this pattern were lower than the control days which belonged to the same period. Days under migratory anticyclone pattern were in the whole period of this study in Sapporo, in autumn in Tokyo and Naha. The temperature of these days in Sapporo and Tokyo was significantly lower than those of the control days.
Most of days under south-high-north-low pattern were in summer in each of the 3 cities. The temperature of the days in Tokyo under this pattern was significantly higher than those of the controls. Days under trough pattern (east-west) were from late summer to autumn in Naha. There was no difference in the temperature between the days under this pattern and the control days.
In summary, some of meteorological conditions had acute effects on asthma frequencies. When significant differences were observed in the temperature, it was lower (higher) in the days under a meteorological condition, under which the asthma frequency was high (low), than in the control days which belonged to the same period.

Dopamine supersensitivity psychosis (DSP) is a type of acute exacerbation of recurrent psychosis caused by long-term treatment with antipsychotics in schizophrenic patients. Although DSP is exceedingly troublesome for clinicians, effective treatment has not yet been established. Based on clinical research and our animal study, we hypothesize that aripiprazole, an atypical anti-psychotic, may reduce the exacerbation of recurrent psychotic episodes. We report the case of a 46-year-old female who suffered from schizophrenia with DSP. In this case, sustained treatment with a high dose of aripiprazole gradually reduced the severity of her recurrent psychotic episodes. In conclusion, sustained treatment with aripiprazole may reduce the exacerbation of recurrent psychotic episodes in schizophrenic patients with DSP, and may be an effective treatment of DSP.
Animals ; Antipsychotic Agents ; Aripiprazole* ; Disease Progression ; Dopamine* ; Female ; Humans ; Middle Aged ; Psychotic Disorders ; Receptors, Dopamine D2 ; Recurrence ; Schizophrenia

A fungal carotid aneurysm is an infrequently occurring infectious aneurysm that is usually treated by antifungal therapy plus surgical debridement of the infected vessel. We herein report an extremely rare case involving a patient with a medical history of bladder cancer treated by Bacillus Calmette– Guérin (BCG) who developed a fungal aneurysm of the internal carotid artery and thrombosis of the superior ophthalmic vein caused by maxillary Aspergillus sinusitis. The patient was successfully treated by antifungal, anticoagulant, and antiplatelet drugs combined with internal carotid artery ligation therapy. Internal carotid artery fungal aneurysm is associated with a high mortality rate, but the present case suggests that it can be successfully treated by antifungal therapy combined with a less invasive endovascular therapy.