2.Incidence of Injection Site Reactions Induced by Vinorelbine and Prevention with Hot Compresses
Makoto Hayashi ; Chie Ohnishi ; Hayato Sugimura ; Kenji Miyazawa ; Akimasa Yamatani ; Hiromu Funaki ; Kenichi Miyamoto
Japanese Journal of Drug Informatics 2013;15(1):8-12
Objective: Patients treated with vinorelbine(VNR)-containing chemotherapy often suffer from injection site reactions. VNR is a moderate vesicant that is well known to cause local venous damage. We conducted this study to identify clinical risk factors related to the incidence of injection site reactions caused by VNR, and whether applying a hot compress was effective for preventing such reactions.
Methods: Medical records were retrospectively investigated for 48 patients treated with chemotherapy regimens containing VNR. Injection site reactions were evaluated for every course and were graded according to the National Cancer Institute Common Toxicity Criteria (version 4.0). Gender, age, body mass index, chemotherapy regimen, dose of VNR, and volume of fluid for flushing the vein were assessed as clinical variables. A hot compress was applied to the vein proximal to the injection site during VNR injection.
Results: The injection site reactions occurred in 29 (60%) among 48 patients received intravenous VNR injection. According to multivariate analysis, use of gemcitabine (GEM) in combination with VNR showed a significant independent correlation with an increased risk of injection site reactions (p=0.019). When hot compress was applied to 21 patients, who experienced phlebitis of VNR, the injection site reaction was occurred to only three patients (p<0.001).
Conclusion: In this study, the risk factor of the injection site reaction by VNR seems to be combination of GEM. Application of hot compresses was effective for preventing injection site reactions by VNR.
3.Prevalence of Dental Disease in Patients Undergoing Heart Valve Surgery
Yoshitsugu Nakamura ; Osamu Tagusari ; Kenichi Saito ; Shizu Oyamada ; Kentaro Honda ; Nobuyuki Homma ; Ryozo Miyamoto ; Kiyoharu Nakano
Japanese Journal of Cardiovascular Surgery 2008;37(4):213-216
Bacteremia from dental disease is the most important cause of infective endocarditis in patients with heart valve disease. However, the prevalence of dental disease in patients undergoing valve surgery has not been clarified. One hundred thirty-seven patients had a dental check-up before heart valve surgery, 82 patients (59.9%) had significant dental disease which could have caused bacteremia. All patients with the dental disease underwent extraction preoperatively. There was neither complication in extraction nor any influence on heart valve surgery. Postoperative hospital stay was not prolonged due to the extraction. During the mean follow-up period of 30 months, no infective endocarditis was seen. The prevalence of dental disease was high in patients undergoing heart valve surgery. Preoperative treatment of dental disease did not have a negative impact on the postoperative course and hospital stay in heart valve surgery.
4.Inhibition of autophagy protein LC3A as a therapeutic target in ovarian clear cell carcinomas.
Morikazu MIYAMOTO ; Masashi TAKANO ; Tadashi AOYAMA ; Hiroaki SOYAMA ; Tomoyuki YOSHIKAWA ; Hitoshi TSUDA ; Kenichi FURUYA
Journal of Gynecologic Oncology 2017;28(3):e33-
OBJECTIVE: Ovarian clear cell carcinoma (CCC) is one of histological subtypes showing poor prognosis due to chemoresistance. The association of autophagy-related proteins and clinical implementation in CCC has not been determined. METHODS: The present study investigated whether expression of autophagy-related protein, light chain 3A (LC3A), was related with prognoses in the patients with CCC using immuno-histochemical stainings, and whether inhibition of autophagy modified the sensitivity to cisplatin in CCC cells in vitro. RESULTS: High expression of autophagy-related protein, LC3A, was detected in 78 cases (78%) in all CCC cases. The patients with high LC3A expression showed significantly lower response rate to primary chemotherapy (17% vs. 100%, p<0.010), and had worse progression-free survival (PFS) and overall survival (OS) compared with those with LC3A low expression. Furthermore, multivariate analyses revealed that high expression of LC3A was identified as independent worse prognostic factors for PFS and OS. Inhibition of autophagy protein LC3A using hydroxychloroquine (HCQ) increased sensitivity to cisplatin in CCC cells in vitro. CONCLUSION: High expression of LC3A proteins was associated with lower response to platinum therapy, leading to worse prognoses in CCC. Although further studies are needed to confirm the results, inhibition of autophagy by HCQ was associated with platinum sensitivity. Autophagy protein LC3A could be a promising target for treatment for CCC.
Adenocarcinoma, Clear Cell
;
Autophagy*
;
Cisplatin
;
Disease-Free Survival
;
Drug Therapy
;
Humans
;
Hydroxychloroquine
;
In Vitro Techniques
;
Multivariate Analysis
;
Ovarian Neoplasms
;
Platinum
;
Prognosis
5.Clear cell histology as a poor prognostic factor for advanced epithelial ovarian cancer: a single institutional case series through central pathologic review.
Morikazu MIYAMOTO ; Masashi TAKANO ; Tomoko GOTO ; Masafumi KATO ; Naoki SASAKI ; Hitoshi TSUDA ; Kenichi FURUYA
Journal of Gynecologic Oncology 2013;24(1):37-43
OBJECTIVE: Compared with serous adenocarcinoma (SAC), clear cell carcinoma (CCC) often shows chemo-resistance, which would potentially lead to a poor prognosis. On the other hand, there have been arguments over prognoses of CCC and SAC disease. In the present study, multivariate analysis to compare prognosis of CCC patients with that of SAC was aimed for the patients selected from central pathologic review. METHODS: Between 1984 and 2009, a total of 500 ovarian cancer patients were treated at our university hospital. Among them, 111 patients with CCC and 199 patients with SAC were identified through central pathological review. Overall survival and progression-free survival were compared using Kaplan-Meier method, and prognostic factors were investigated by multiple regression analyses. RESULTS: Median age was 52 years for CCC and 55 years for SAC (p=0.03). The ratio of stage I patients were significantly higher in CCC compared with SAC (55% vs. 13%, p<0.01). Among evaluable cases, response rate was significantly lower in CCC than that in SAC (32% vs. 78%, p<0.01). No significant differences of progression-free survival and overall survival were observed in stage I patients; however, prognoses of CCC were significantly poorer than those of SAC in advanced-stage disease. In stage II-IV patients, not only residual tumors and clinical stages, but also clear cell histology were identified as predictors for poor prognosis. CONCLUSION: Clear cell histology was identified as a prognostic factor for advanced-stage ovarian cancers. Histologic subtypes should be considered in further clinical studies, especially for advanced epithelial ovarian cancers.
Adenocarcinoma
;
Adenocarcinoma, Clear Cell
;
Chlormequat
;
Cystadenocarcinoma, Serous
;
Disease-Free Survival
;
Hand
;
Humans
;
Multivariate Analysis
;
Neoplasm, Residual
;
Ovarian Neoplasms
;
Prognosis
6.DNA mismatch repair-related protein loss as a prognostic factor in endometrial cancers.
Masafumi KATO ; Masashi TAKANO ; Morikazu MIYAMOTO ; Naoki SASAKI ; Tomoko GOTO ; Hitoshi TSUDA ; Kenichi FURUYA
Journal of Gynecologic Oncology 2015;26(1):40-45
OBJECTIVE: Recent investigations have revealed DNA mismatch repair (MMR) gene mutations are closely related with carcinogenesis of endometrial cancer; however the impact of MMR protein expression on prognosis is not determined. Correlations between MMR-related protein expression and clinicopathological factors of endometrial cancers are analyzed in the present study. METHODS: A total of 191 endometrial cancer tissues treated between 1990 and 2007 in our hospital were enrolled. Immunoreactions for MSH2, MLH1, MSH6, and PMS2 on tissue microarray specimens and clinicopathological features were analyzed retrospectively. RESULTS: Seventy-six cases (40%) had at least one immunohistochemical alteration in MMR proteins (MMR-deficient group). There were statistically significant differences of histology, International Federation of Gynecology and Obstetrics (FIGO) stage, and histological grade between MMR-deficient group and the other cases (MMR-retained group). Response rate of first-line chemotherapy in evaluable cases was slightly higher in MMR-deficient cases (67% vs. 44%, p=0.34). MMR-deficient cases had significantly better progression-free and overall survival (OS) compared with MMR-retained cases. Multivariate analysis revealed MMR status was an independent prognostic factor for OS in endometrial cancers. CONCLUSION: MMR-related proteins expression was identified as an independent prognostic factor for OS, suggesting that MMR was a key biomarker for further investigations of endometrial cancers.
Adaptor Proteins, Signal Transducing/deficiency/metabolism
;
Adenosine Triphosphatases/deficiency/metabolism
;
Adult
;
Aged
;
Aged, 80 and over
;
Chemotherapy, Adjuvant
;
*DNA Mismatch Repair
;
DNA Repair Enzymes/deficiency/*metabolism
;
DNA-Binding Proteins/deficiency/*metabolism
;
Endometrial Neoplasms/*diagnosis/drug therapy/genetics/pathology
;
Female
;
Humans
;
Kaplan-Meier Estimate
;
Middle Aged
;
MutS Homolog 2 Protein/deficiency/metabolism
;
Neoplasm Proteins/deficiency/metabolism
;
Nuclear Proteins/deficiency/metabolism
;
Prognosis
;
Retrospective Studies
;
Tumor Markers, Biological/*metabolism
7.Objectives for Practicing Physicians' Continuing Medical Education.
Yutaka HIRANO ; Hiroshi KIKUCHI ; Kenichi KOBAYASHI ; Masahiko HATAO ; Tsutomu IWABUCHI ; Akira KURAI ; Naohiko MIYAMOTO ; Takao NAKAKI ; Osamu NISHIZAKI ; Hirosuke SUZUKI ; Kyoichi UENO ; Daizo USHIBA
Medical Education 1994;25(6):365-367
8.Check List for Practicing Physicians' Continuing Medical Education.
Yutaka HIRANO ; Hiroshi KIKUCHI ; Kenichi KOBAYASHI ; Masahiko HATAO ; Tsutomu IWABUCHI ; Akira KURAI ; Naohiko MIYAMOTO ; Takao NAKAKI ; Osamu NISHIZAKI ; Hirosuke SUZUKI ; Kyoichi UENO ; Daizo USHIBA
Medical Education 1995;26(1):51-61
9.Seromucinous component in endometrioid endometrial carcinoma as a histological predictor of prognosis.
Morikazu MIYAMOTO ; Masashi TAKANO ; Tadashi AOYAMA ; Hiroaki SOYAMA ; Tomoyuki YOSHIKAWA ; Hitoshi TSUDA ; Kenichi FURUYA
Journal of Gynecologic Oncology 2018;29(2):e20-
OBJECTIVE: In 2014 World Health Organization criteria, seromucinous carcinoma was defined as a new histological subtype in ovarian carcinomas, but “seromucinous carcinoma” was not defined in endometrial carcinomas. The aim of this study was to identify seromucinous carcinoma resembling ovarian seromucinous carcinoma in endometrial carcinomas, and to evaluate the clinical significance for prognoses of the patients. METHODS: Central pathological review was conducted for patients with endometrioid carcinoma of the endometrium treated by primary surgery at our hospital between 1990 and 2013. RESULTS: Among 340 cases included in the study, no case had all tumor cells resembling ovarian seromucinous carcinoma in all specimens, and 31 cases (9.1%) had seromucinous component in combination with endometrioid carcinomas. Immunohistochemical analysis revealed seromucinous component had positive reactivity for cytokeratin (CK) 7, and negative reactivity for CK20 and caudal type homeobox 2 (CDX2) in all cases. Seromucinous component showed lower immunoreactivity of estrogen receptor and progesterone receptor, compared with endometrioid carcinoma component. Progression-free survival of the cases with seromucinous component was better than those without seromucinous component (p=0.049). CONCLUSION: Seromucinous component was identified in approximately 10% of endometrioid carcinoma, and could be a histological predictor for prognosis.
Carcinoma, Endometrioid
;
Disease-Free Survival
;
Endometrial Neoplasms*
;
Endometrium
;
Estrogens
;
Female
;
Genes, Homeobox
;
Humans
;
Keratins
;
Prognosis*
;
Receptors, Progesterone
;
World Health Organization
10.10-11 Having Residents under the COVID-19 Pandemic - Experiences in the Spring of 2020
Kayoko MATSUSHIMA ; Eriko OZONO ; Yusuke MATSUZAKA ; Syoko ASHIZUKA ; Noriko SHIGETOMI ; Toshimasa SHIMIZU ; Masafumi HARAGUCHI ; Takeshi WATANABE ; Takashi MIYAMOTO ; Hayato TAKAYAMA ; Kenichi KANEKO ; Yuji KOIDE ; Atsuko NAGATANI ; Hisayuki HAMADA
Medical Education 2020;51(3):331-333