Background: Lung cancer is one of the leading causes of cancer-related mortality worldwide. Pulmonary nodules are commonly encountered in clinical practice because of the recent implementation of low-dose CT lung screening programme, incidental finding on cardiac CT or CT for nonthoracic related disease. 18 F-FDG PET-CT plays an important role in the management of pulmonary nodules. Methods: In this pictorial review, we present six different scenarios of using 18 F-FDG PET-CT in the management of suspicious pulmonary nodule or mass. The advantages and limitations of 18 F-FDG PET-CT and Herder model are discussed. Results: 18 F-FDG PET-CT with risk assessment using Herder model provides added value in characterising indeterminate pulmonary nodules. Besides, 18 F-FDG PET-CT is valuable to guide the site of biopsy and provide accurate staging of lung cancer. Conclusion: To further improve its diagnostic accuracy, careful history taking, and CT morphological evaluation should be taken into consideration when interpreting 18FFDG PET-CT findings in patients with these nodules.