Objective To investigate the clinical significance of noninvasive heart function monitor of diagnosis and therapy of chronic pulmonary heart disease.Methods The PAP and right heart function of exacerbation period and stable period of chronic pulmonary heart disease,and that of normal healthy controls were monitored.T test were used for statistics.Results Compared exacerbation and stable period of chronic pulmonary heart disease with stable period,the RVPS,PAPS,SVR,PVR,RCI,RCRI,the difference was significant(P0.05).Conclusion Noninvasive heart function monitor is a sensitive way to diagnose and to judge therapy effect of chronic pulmonary heart disease.

[Objective]To investigate the effect of an effervescent-sucrose on the properties of calcium phosphate cement. [Method]The sucrose particles were mixed with CPC powder at sucrose/(sucrose+CPC powder) mass percentage of 0%,10%,20%,30%,40%.The samples were characterized by compressive strength,X-ray diffraction,SEM techniques and degradation in vivo.[Result]The samples decreased on the mechanical properties and increased on the rate of macropore and total porosity,they were effected significantly among groups by added effervescent(P

ObjectiveTo evaluate the effect and complication of whole γ-knife stereotactic radiotherapy on the non-small cell lung cancer and explore the value of γ-knife stereotactic radiotherapy in treatment of non - small cell lung cancer. Methods42 patients with non -small cell lung cancer:γ-knife radiotherapy patients ,4 ～ 8Gy once a day,five times a week,4 ～ 10times and 40 ～50Gy in total. ResultsThe overall response rate (CR + PR) in γ-knife was 71.4％. The1-,2-and 3-year survival rates were 95.5％, 59.5％, 33.3％. ConclusionCompared with conventional radiation,γ-knife stereotactic radiotherapy could achieve tumor dose escalation,and give the normal tissue better protection at the same time. It could improve the tumor control rate of non-small cell lung cancer,improve long survival rate,and so could reduce the radiation reaction.

ObjectiveTo investigate current status and demand of continous general practice (GP) education in Shanghai.Methods Two hundred and twenty general practitioners from 10 community health service centers of Shanghai underwent a questionnaire survey.Chi-square test was used for data analysis.ResultsThe effective response rate was 96.57％(212/220).About 87 percent of the participants considered continous GP education was helpful.Nearly 55 percent of the participants were satisfied withcurrentcontinousGP education.Unsatisfaction withcontinuing GP education,wishto reparticipate continous GP education,expected method and content of training were partly related to professional title and age.Ninety-seven percent of the participants thought the assessment of continuous GP education should include clinical practical capability evaluation.Conclusion The present continous GP education in Shanghai is not matched with GP's demand.Continous GP education should meet different needs of general practioners in different ways.

Background Horizontal sulcus-to-sulcus (STS) and white-to-white diameter are important parameters for designing the proper size of collamer implantable contact lens (ICL).Inappropriate size of ICL may induce the complications postoperatively.Several previous studies compare horizontal STS and white-to-white diameter in normal eyes have been reported,but seldom in high myopic eyes.Objective This study was to investigate the discrepancy of STS diameters in 4 axes and analyze the relationship between horizontal STS diameter and white-towhite diameter in high myopia eyes.Methods The STS diameters in 4 axes (45,90,135 and 180 degrees) and the white-to-white diameters were measured in 48 eyes of 26 high myopia patients using the 50 MHz ultrasound biomicroscopy (UBM),the Orbscan-Ⅱ topography system,and the IOL Master,respectively.The mean spherical was (-12.93±3.87) diopters (D) (-8 to-20 D).Statistical evaluation was performed using the one-way ANOVA for comparison of measurement.The agreement of three devices was assessed using the Bland and Altman method.Results The mean STS diameter at 45,90,135 and 180 degrees was (12.06±0.50) mm,(12.27±0.50)mm,(12.03±0.46) mm and (11.84±0.47)mm,respectively.The 90 degree STS was significantly larger than other STS diameters (all at P＜0.05).The 180 degrees STS was significantly shorter than other STS diameters (all at P＜0.05).However,there was no significant difference between 45 degree STS and 135 degree STS (P=0.817).The mean WTW was (11.56±0.40) mm with Orbscan Ⅱ z topography system and (11.98±0.41) mm with IOLMaster.The WTW measured with Orbscan Ⅱ z was significantly shorter than the 180 degrees STS (t =-4.384,P =0.000).The WTW measured with IOLMaster was significantly larger than the 180 degrees STS (t =2.368,P =0.000).Bland-Altman analysis showed not very well agreement for measurements of WTW,STS between Orbscan Ⅱz and UBM,IOLMaster and UBM,Orbscan Ⅱ z and IOLMaster,the width of 95％ confidence interval (CI) were-0.57 to 1.12 mm,-0.96 to 0.67 mm,-0.73 to-0.13 mm,respectively.Conclusions The STS diameters in 4 different axes are not identical with each other in high myopia eyes.The longest STS is in the vertical meridian,the shortest STS is in the horizontal meridian.The WTW diameter measured with both Orbscan Ⅱ z and IOLMaster are not precise for calculating the horizontal STS in high myopia eyes.Three instruments cannot be interchanged for calculating the size of ICL.

Objective To investigate the effect of laparoscope combined with ureteroscope for the treatment of hepatolithus. Methods 98 patients were randomly divided into two groups:the study group(laparoscope combined with ureteroscope group) and the control group (the open surgery group). The mean blood loss, the recovery of the stomach and intestines function, hospital stay and the rate of complications were observed. Results Compared with the open surgery group,the mean blood loss,the recovery of the stomach and intestines function,and hospital stay in the study group had statistically significant difference (all P＜0. 05). Compared with the open surgery group, the time of surgery and the patients carryingT tubes in the study group had statistically significant difference (all P＜0. 05). Compared with the open surgery group, the rate of gallstone removal、the rate of gallstone residual and the rate of injures in the study group had no statistically significant difference(all P＞0. 05). Conclusion Laparoscope combined with ureteroscope in patients with hepatolithus had the advantage of less trauma, faster postoperative recovery and fewer complications. It was safe and effective,so it was worth to recommend its clinical use.

A total of 216 patients with type 2 diabetes mellitus and their family members were randomly divided into intervention and control groups.On the basis of conventional drug therapy,for intervention group,the patients and their family members were instructed to participate in health education activities and self-monitoring guidance.For control group,only patients were required to participate.The intervention continued for 12 months.Compared with control group,the intervention group significantly improved their living habits and the level of knowledge structure.The levels of low-density lipoprotein (LDL),2 h postprandial blood glucose and glycated hemoglobin improved after intervening.And there were statistically significant differences (P ＜ 0.05).The family members of patients had more knowledge of identifying and dealing with low blood sugar while their knowledge of medication and regular monitoring was significantly better than that of control group.And there were statistically significant differences (P ＜ 0.05).Family-involved diabetic management is conducive for forming diabetic self-management behaviors.

Objective To study the pharmacological mechanism of glucosides of tripterygium(GTW)inducing reproductive hypofunction in female mature mice and to establish female mice model of reproductive hypofunction.Methods Female Kunming mice aged 7～ 8 weeks were randomly divided into 6 groups,including GTW groups of A,B,C,D and E(60,40,30,20,15 mg? kg-1? d-1)and normal group.Estrous cycle of five GTW groups was observed successively.To study the effect of GTW on reproductive function in different period,three batches of mice were killed when estrous cycle of some mices was prolonged,estrous cycle of all the mice was prolonged or became irregular,or estrous cycle of all the mice was totally disturbed or even disappeared.Serum E2 and P levels were measured by radioimmunoassay.Ovary and uterus index were measured by tissue-weight-assay,and tectology observation on ovary and uterus was conducted.The numbers of follicle and corpus luteum as well as thickness of endometrium and myometrium were also measured.Results The mice were killed in batches after administration for 5,7,10 weeks.After 10-week treatment,uterus index and the numbers of follicle and luteum were decreased significantly,and endometrium and myometrium also became obviously thinner in groups A,B,and C.E2 level in groups A and B was decreased.P level and ovary index of all treatment groups were not decreased after 10-week treatment.Conclusion GTW at the dosages of 60,40 and 30 mg? kg-1? d-1 can damage female mice' s reproductive function and can induce mice reproductive hypofunction with kidney deficiency after 10-week successive treatment.GTW at the dosage of 40 mg? kg-1? d-1 for 10 weeks is recommended to establish female mice model of reproductive hypofunction with kidney deficiency.

Objective To investigate the effect of hirudo micropowder on inflammatory factors in rats with cerebral ischemia-reperfusion injury.Methods Rats were randomly divided into sham-operation group,model group,coarse powder hirudo group,high-,middle-and low-dose micropowder hirudo groups.The corresponding drugs were given to the rats for 10 days by intragastric administration.Then middle cerebral artery occlusion(MCAO) model was made by suture method.The changes of inflammatory factors were observed.Results The level of intercellular adhesion molecule 1(ICAM-1) in high-dose micropowder hirudo group was lower than that in coarse powder hirudo group,and the level of platelet-derived growth factor(PDGF) in middle-and high-dose micropowder hirudo groups was also lower than that in coarse powder hirudo group obviously(P

369 patients with hypertension living in Xietu community were randomized into 2 groups:intervention group receiving the group-interference-management and control group receiving routine hypertension management services.We found that patients in the intervention group had better self-management behaviors,self-efficacy and health status in comparison with the control group (P＜0.05).The systolic and diastolic blood pressure in the intervention group decreased more remarkably than that in the control group (P＜0.05).Our result suggested that the community-based hypertension group-interference-management model is more effective to control hypertension than the routine hypertension management services.