Objective: To study the expressions of p33ING1, estrogen receptor(ER),progestrone receptor(PR) and c-erbB-2 in the specimens of thyroid carcinomas. Methods:The immunohistochemical methods(SP) were used to detect the expressions ofp33ING1',ER,PR and c-erbB-2 in specimens of thyroid adenomas (TA) and thyroid carcinomas (TC). Results:The positive expression rates of p33ING1, ER, PR and c-erbB-2 protein were76.5%,35.0%,40.0% and 5.0% in TA; and 41.2%,57.8%,64.4%and 46.7% in TC, respectively. There was a significant difference between groups (P＜0.05 or P＜0.01). There was a negative correlation between expressions of e-erbB-2 protein and p33ING1, ER, PR(r=-0.218, -0.221, -0.213, P＜0.01). Conclusion:It may play an important role that p33ING1, ER, PR and e-erbB-2 protein in occurrence and development of thyroid carcinoma,and they may be factors to predict the prognosis of thyroid carcinoma.

Objective To study the clinicopathological characteristics and the immunohistochemistry of supratentorial parenchymal ependymoma.Methods The clinical and pathological data of 12 patients with supratento-rial parenchymal ependymoma were analyzed,and the tissue slices were immunohistochemically stained.Results The average age of the patients was 29 years old.Most of the lesions occurred in the frontal and parietal lobes,with increased intracranial pressure as the main clinical symptom,including headache,dizziness,nausea and vomiting.The histology showed that the structure of supratentorial parenchymal ependymoma was consistent with that of infratentorial ependymoma.The tumor cells were oval or spindle shaped,diffuse or patchy distribution,small volume,large nuclear staining deep,and were arranged in Flexner-Winterseiner or Homer-Wright.The immunohistochemistry showed that GFAP,vimentin and S-100 were mostly positive,EMA was partly positive and CD56 and NSE were rarely positive. Conclusion Supratentorial parenchymal ependymoma can occur in any part of the supratentorium,mostly in the fron-tal and parietal lobes.It has a specific pathological morphology and immune phenotype,without any characteristic symptoms in clinical,which is easy to be misdiagnosed.Its diagnosis depends on the pathological examination and the prognosis is largely related to whether the surgical resection is complete or not.

Objective To detect the expression of PCNA and Ki-67 proliferation antigens in thyroid neoplasms and to study diagnostic value of expression of PCNA and Ki-67 in benign and malignant neoplasms of thyroid. Methods The expression of PCNA and Ki-67 in 76 thyroid neoplasms was examined by immunohistochemical method(EnVision MT ). Results Among the 39 thyroid adenomas(TA), the indices of PCNA and Ki-67 were 0 16?0 09(39/39) and 1 49?1 15(39/39) respectively; Among the 37 thyroid carcinomas(TC), the indices of PCNA and Ki-67 were 0 43?0 31(37/37) and 2 13?1 52(37/37) respectively. The differences of both the PCNA and Ki-67 indices between TA and TC were significant(P

Objective To investigate the expressions of proliferating cell nuclear antigen (PCNA), bcl-2, and c-myc protein, and to explore diagnostic value of DNA ploidy in benign and malignant thyroid neoplasms. Methods The expressions of PCNA, bcl-2 and c-myc proteins in 36 cases of thyroid adenomas and 37 cases of thyroid carcinomas were examined by immunohistochemistry technique. DNA ploidy was measured by imaging analysis technique in 8 cases of thyroid adenomas and 17 cases of thyroid carcinomas. Results Among thyroid carcinomas, the positive rates of PCNA (43.02?31.16)% and c-myc protein 89.2% were significantly higher than those of thyroid adenomas (16.15?9.28)% and 50.0% respectively (both P

Objective To evaluate the curative effect of compound nutrient assisted phototherapy on neonatal jaundice.Methods Neonatologists at seven hospitals participated in the study.A total of three hundred and twenty full-term newborns with high indirect bilirubin admitted to hospital from September 2017 to January 2018 were selected.One hundred and sixty-six cases in the observation group,and one hundred and fifty-four cases in the control group,all enrolled neonates were given single-sided,conventional intensity phototherapy.Observation group took compound nutrient at the same time.The average gestational age,age,birth weight of two groups before treatment were not significantly different.Serum total biilirubin,indirect bidirubin,liver function (ALT,AST) and phototherapy time were monitored before treatment and 3 days after treatment.Results The serum total bilirubin in the observation group was significantly lower than that of the control group after 3 days of treatment[(196.7 ± 57.2) μmol/L vs (216.5 ± 54.6) μmol/L],(t=3.17,P＜0.01).The indirect bilirubin in the observation group was significantly lower than that of the control group after 3 days of treatment [(176.3 ± 54.3) μmol/L vs (197.2 ± 52.9) μmol/L],(t=3.50,P＜0.01).The time of phototherapy of the children in the observation group was significantly shorter than that of the control group[(19.8 ± 14.4)d vs (22.9 ± 13.3) d],(t =2.00,P ＜ 0.01).Rash,fever,bronze disease,spilled milk,vomiting,abdominal distention,diarrhea,constipation,liver damage etc.were no significant difference the observation group and the control group(P ＞ 0.05).Conclusion Compound nutrients had good efficacy and safety in adjuvant phototherapy for neonatal high indirect bidirubin.