1.Health Survey of the Dairy Farmers of Bekkai Area in Hokkaido, Japan, With Special Reference to the Influence on the Farmers' Health of the Mechanization of Dairy Farming
Keizo Fujii ; Yoshinori Iriuda ; Kazuhiko Masuda ; Hiroko Tanaka
Journal of the Japanese Association of Rural Medicine 1975;24(4):633-634
2.A Case of Left Atrial Myocardial Abscess Complicating Bicuspid Aortic Valve Infective Endocarditis
Hitoshi Suzuki ; Keizo Tanaka ; Shinji Kanemitsu ; Toshiya Tokui ; Yoshihiko Kinoshita
Japanese Journal of Cardiovascular Surgery 2006;35(1):49-52
A 56-year-old man was admitted with fever of unknown origin and congestive heart failure. Blood cultures grew Streptococcus gordonii. An echocardiographic examination showed vegetation attached to the bicuspid aortic valve and severe aortic regurgitation. Despite the aggressive therapy, an emergency operation had to be performed because it was otherwise impossible to control heart failure. Vegetation was attached to the aortic valve leaflets. There was no noticeable lesion on the aortic annulus, but a myocardial abscess was noted in the left atrial wall. Aortic valve replacement was performed after the myocardial abscess was drained. It was assumed that the myocardial abscess was due to the septic state from Infective endocarditis because it was recognized at a distant zone from the active valvular infection.
3.Resident Training in U.S.A.
Ryo TANAKA ; Hiroshi NAKAJIMA ; Keizo HIRAYAMA ; Tadashi HINOHARA
Medical Education 1971;2(3):199-208
4.A Case of Aortic Valve Rereplacement due to Complications of Autoimmune Hemolytic Anemia
Hitoshi Suzuki ; Hideki Ito ; Keizo Tanaka ; Shinji Kanemitsu ; Jin Tanaka ; Yoshihiko Kinoshita
Japanese Journal of Cardiovascular Surgery 2007;36(1):45-47
A 64-year-old man who underwent aortic valve replacement with a 25mm Bjork-Shiley valve in 1993 began to have severe anemia and required repeated transfusions by November 2003. Doppler echocardiography showed only mild aortic regurgitation, but revealed turbulent flow around the mechanical valve. Autoimmune hemolytic anemia (AIHA) was diagnosed and he was treated with prednisolone (PSL) starting May 2004. Because of unremitting hemolysis requiring multiple transfusions and the occurrence of renal dysfunction, he underwent rereplacement of the aortic valve with a 25-mm Freestyle valve. His hemolysis and general condition immediately improved. This case suggests the possibility that mild regurgitant jet and turbulent jet stress can cause severe hemolysis when AIHA develops.
5.Characterizing mouse male germ cell-specific actin capping protein alpha3 (CPalpha3): dynamic patterns of expression in testicular and epididymal sperm.
Keizo TOKUHIRO ; Yasushi MIYAGAWA ; Hiromitsu TANAKA
Asian Journal of Andrology 2008;10(5):711-718
AIMTo characterize mouse capping protein alpha3 (CPalpha3) during spermatogenesis and sperm maturation.
METHODSWe produced rat anti-CPalpha3 antiserum and examined the expression of CPalpha3 in various mouse tissues using Western blot analysis and the localization of CPalpha3 in testicular and epididymal sperm using immunohistochemical analyses. We also examined how the localization of CPalpha3 and beta-actin (ACTB) in sperm changed after the acrosomal reaction by performing immunohistochemical analyses using anti-CPalpha3 antiserum and anti-actin antibody.
RESULTSWestern blot analysis using specific antiserum revealed that CPalpha3 was expressed specifically in testes. Interestingly, the molecular weight of CPalpha3 changed during sperm maturation in the epididymis. Furthermore, the subcellular localization of CPalpha3 in sperm changed dynamically from the flagellum to the post-acrosomal region of the head during epididymal maturation. The distribution of ACTB was in the post-acrosomal region of the head and the flagellum. After inducing the acrosomal reaction, the CPalpha3 and ACTB localization was virtually identical to the localization before the acrosomal reaction.
CONCLUSIONCPalpha3 might play an important role in sperm morphogenesis and/or sperm function.
Acrosome Reaction ; physiology ; Actins ; metabolism ; Animals ; Blotting, Western ; CapZ Actin Capping Protein ; metabolism ; Cells, Cultured ; Epididymis ; cytology ; metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Sperm Head ; metabolism ; Sperm Tail ; metabolism ; Spermatogenesis ; physiology ; Spermatozoa ; cytology ; metabolism ; Testis ; cytology ; metabolism
6.Association between Lymphovascular Invasion and Recurrence in Patients with pT1N+ or pT2–3N0 Gastric Cancer: a Multi-institutional Dataset Analysis
Keizo FUJITA ; Mitsuro KANDA ; Seiji ITO ; Yoshinari MOCHIZUKI ; Hitoshi TERAMOTO ; Kiyoshi ISHIGURE ; Toshifumi MURAI ; Takahiro ASADA ; Akiharu ISHIYAMA ; Hidenobu MATSUSHITA ; Chie TANAKA ; Daisuke KOBAYASHI ; Michitaka FUJIWARA ; Kenta MUROTANI ; Yasuhiro KODERA
Journal of Gastric Cancer 2020;20(1):41-49
PURPOSE:
Patients with pathological stage T1N+ or T2–3N0 gastric cancer may experience disease recurrence following curative gastrectomy. However, the current Japanese Gastric Cancer Treatment Guidelines do not recommend postoperative adjuvant chemotherapy for such patients. This study aimed to identify the prognostic factors for patients with pT1N+ or pT2–3N0 gastric cancer using a multi-institutional dataset.
MATERIALS AND METHODS:
We retrospectively analyzed the data obtained from 401 patients with pT1N+ or pT2–3N0 gastric cancer who underwent curative gastrectomy at 9 institutions between 2010 and 2014.
RESULTS:
Of the 401 patients assessed, 24 (6.0%) experienced postoperative disease recurrence. Multivariate analysis revealed that age ≥70 years (hazard ratio [HR], 2.62; 95% confidence interval [CI], 1.09–7.23; P=0.030) and lymphatic and/or venous invasion (lymphovascular invasion (LVI): HR, 7.88; 95% CI, 1.66–140.9; P=0.005) were independent prognostic factors for poor recurrence-free survival. There was no significant association between LVI and the site of initial recurrence.
CONCLUSIONS
LVI is an indicator of poor prognosis in patients with pT1N+ or pT2–3N0 gastric cancer.
7.A Case of Direct Oral Anticoagulant (DOAC) as Anticoagulant after Mitral Valvuloplasty in a Patient with Warfarin-Resistance
Shunsuke WADA ; Takashi HASHIMOTO ; Koh KAJIYAMA ; Keizo TANAKA
Japanese Journal of Cardiovascular Surgery 2024;53(6):343-347
Warfarin is commonly used as an anticoagulant after mitral valvuloplasty (MVP). The efficacy of warfarin varies widely from patient to patient, and sometimes optimal prolongation of PT-INR cannot be achieved even with high doses of warfarin. In the present case, PT-INR was not prolonged to the target value even after 9 mg of warfarin and 300 mg of Bucolome due to warfarin resistance, and a direct oral anticoagulant (DOAC) was administered as an alternative drug. The patient was a 57-year-old male who became aware of easy fatigue and visited a medical institution for a heart murmur. Transthoracic echocardiography revealed a severe mitral regurgitation (MR) due to thickening of the anterior mitral leaflet and prolapse of the posterior leaflet. Postoperative echocardiography showed no MR, good valve mobility, an effective valve opening area of 2.0 cm2, and an improved blood flow velocity of 0.9 m/s. Warfarin was started on the day after surgery, but the dose was gradually increased because PT-INR was not prolonged. The PT-INR was less than 1 even with 6 mg of warfarin, and the patient was started on Bucolome. The PT-INR was 1.27 after 9 mg of warfarin and 300 mg of Bucolome. The patient was diagnosed as warfarin-resistance and was discharged from the hospital after warfarin was discontinued and dabigatran 300 mg was administered. Dabigatran was discontinued at 3 months after surgery without any embolism or bleeding complications. In some cases, PT-INR prolongation may not be achieved due to warfarin resistance caused by genetic polymorphisms, and in such cases, DOACs can be used as anticoagulants after mitral valvuloplasty.