Rikkunshito is comprised of 8 crude drugs and is used for the treatment of gastrointestinal dysfunctions such as anorexia and heavy stomach feeling. These symptoms are often caused by delay in gastric emptying. Cisplatin is a representative cancer chemotherapeutic drug with severe adverse effects such as anorexia and nausea, that gives rise to a delay in gastric emptying. However, it is still unknown whether rikkunshito has effects on improving the delayed gastric emptying induced by cisplatin. In the present study, we examined the effects of rikkunshito (an Atractylodis rhizoma-containing formula) on cisplatin-induced delay in gastric emptying in the rat. Rikkunshito improved this. Among the crude drugs that comprise rikkunshito, Atractylodis rhizoma, Ginseng radix, Poria and Aurantii nobilis pericarpium individually improved the delay in gastric emptying, suggesting that they all contribute to the action of rikkunshito. Moreover, the effects of these 4 crude drugs in combinations were also examined, and as a result, tended to be stronger when Atractylodis rhizoma was included. On the other hand, when Atractylodis rhizoma was excluded from rikkunshito, the effects were weaker. Meanwhile, atractylenolide III, a specific chemical constituent of Atractylodis rhizoma, improved delay in gastric emptying in a manner similar to that of rikkunshito with Atractylodis rhizoma. These results, taken together, suggest that Atractylodis rhizoma likely contributes greatly to the improving effect of rikkunshito on cisplatin-induced delay in gastric emptying.

This study was a nonrandomized controlled trial, aimed to identify the effects of a walking program designed to improve the physical functions of elderly people requiring support or low-level care and receiving rehabilitation services at day care centers. Participants were 28 elderly people (mean age: 77.9±7.5 years). Twelve participants agreed to wear a physical activity monitoring device. Their daily walking goals were updated every week. Sixteen subjects designated as a control group only underwent personalized rehabilitation programs. The gait functions of all subjects were evaluated by several gait parameters before and after the 4-week intervention. ADL and QOL were assessed using the Tokyo Metropolitan Institute Gerontology Index of Competence and 8-Item Short-Form Health Survey (SF-8), respectively. The step length, walking angle, the stance phase ratio and the double-support phase ratio significantly improved in the intervention group after the walking program. Interaction effects of the stance phase ratio, the double-support phase ratio and QOL (mental component summery) were observed between the two groups. The walking program, combined with rehabilitation services, showed favorable effects on the gait functions, and QOL of elderly people, suggesting that it may be useful for preventing functional deterioration of the elderly requiring support or low-level care.